A5020151885- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Nutrition and Health in Aging
- Obstructive Sleep Apnea Research
- Clinical Nutrition and Gastroenterology
- Autoimmune and Inflammatory Disorders Research
- Venous Thromboembolism Diagnosis and Management
- Sphingolipid Metabolism and Signaling
- Child Nutrition and Feeding Issues
- Colorectal Cancer Screening and Detection
- Multiple Sclerosis Research Studies
- Oral health in cancer treatment
- Viral Infections and Immunology Research
- Cardiac Imaging and Diagnostics
- Fuel Cells and Related Materials
- Ultrasound in Clinical Applications
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Function and Risk Factors
- Neutropenia and Cancer Infections
- Gastric Cancer Management and Outcomes
- Migraine and Headache Studies
- Diagnosis and Treatment of Venous Diseases
- Enhanced Recovery After Surgery
- Dermatological and COVID-19 studies
- Trigeminal Neuralgia and Treatments
Masaryk University
2019-2025
Samara Medical Institute Reaviz
2023-2024
Czech Radio
2022
St. Anne's University Hospital Brno
2013-2020
University Hospital Brno
2013-2020
International Clinical Research Center, St. Anne's University Hospital Brno
2013
Loss of muscle mass occurs rapidly during critical illness and negatively affects quality life. The incidence clinically significant wasting in critically ill patients is unclear. This study aimed to assess the identify predictors for loss this patient population. was a single-center observational study. We used ultrasound determine rectus femoris cross-sectional area (RFcsa) on first seventh day ICU stay. primary outcome wasting. logistic regression model Ultrasound measurements were...
Nutritional support is associated with improved clinical outcomes in critically ill patients; however, loss of muscle mass during critical illness leads to weakness, delayed return work, and increased healthcare consumption. Animal data have suggested that intermittent feeding decreases protein catabolism. This study was aimed at determining whether the mode enteral nutrition administration might lead differences meeting nutritional goals, tolerance, complications. A prospective, randomized,...
The objective of this study was to investigate the prognostic significance frequency primary cilia (PC) and β-catenin expression in 218 patients (pts) with non-small cell lung cancer (NSCLC), including 125 pts adenocarcinoma 93 squamous carcinoma. In whole group NSCLC, overall survival (OS) significantly inferior among present PC than without (p=0.024) higher cytoplasmic (25-75%) lower (<25%) (p=0.008). univariate Cox proportional hazard model, ratio 1.653 (p=0.026) 1.851 (p=0.009)....
The presence of metaphase II (MII) spindle together with the polar body (PB) indicates completion oocyte maturation. This study was designed to explore if imaging can be used optimize timing intracytoplasmic sperm injection (ICSI).The involved 916 oocytes from 234 conventionally stimulated ICSI cycles an unexpectedly poor ovarian response. All PB-displaying were subjected polarized light microscopy (PLM) prior ICSI. When MII absent in majority oocytes, postponed and performed after...
Patients with chest pain, elevated troponin, and unobstructed coronary disease present a clinical dilemma. The purpose of this study was to investigate the incremental diagnostic value cardiovascular magnetic resonance (CMR) in cohort patients suspected acute syndrome (ACS) arteries. Data files meeting inclusion criteria two cardiology centres were searched analysed. included: 1) thoracic pain ACS; 2) significant increase high-sensitive Troponin T value; 3) ECG changes; 4) arteries without...
Summary Our observational study analysed fungal infection frequency within cohorts with versus without antifungal prophylaxis (AFP) among newly diagnosed first‐line venetoclax and azacitidine (VEN + AZA)‐treated acute myeloid leukaemias in Czech, Austrian Slovak haematology centres. Among 186 patients, 85 (46%) received prophylaxis, while 101 (54%) no prophylaxis. Fungal infections occurred 1/85 patients (1%) 5/101 (5%) ( p = 0.222). No significant difference was recorded between AFP terms...
Abstract Background Enteral nutrition is part of the treatment critically ill patients. Administration enteral may be associated with signs intolerance, such as high gastric residual volumes, diarrhea, and vomiting. Clinical trials regarding effects mode administration on occurrence these complications have yielded conflicting results. This trial aims to investigate whether affects time reach nutritional targets, complications. Methods COINN a randomized, monocentric study for adult patients...
Around 20-40% of heart transplant patients experience moderate to severe rejection within the first year after transplantation. Endomyocardial biopsy (EMB) is a gold standard for diagnosing rejection. There need non-invasive alternatives that allow early, safe and reliable diagnosis acute graft prior onset clinical symptoms.Our aim was investigate potential speckle tracking derived strain analysis in rejection.Patients indicated EMB consented trans-thoracic echocardiography examination (TTE)...
Despite the continuously growing number of therapeutic options for patients with type 2 diabetes mellitus (T2DM), a large percentage these individuals fail to achieve their glycated hemoglobin (HbA1c) target. The aim this study was determine change in metabolic control insulin-naïve T2DM inadequately controlled oral antidiabetic drugs (OADs) at 6 months after initiating basal insulin treatment as add-on existing OADs. This non-interventional prospective conducted from June 2013 December 2014...
Vagal nerve stimulation (VNS) can be indicated in patients with drug-resistant epilepsy, who are not eligible for resective epilepsy surgery. In VNS therapy, the responder rate (i.e., percentage of subjects experiencing ≥50% seizure reduction) is ~50%. At moment, there no widely-accepted possibility to predict efficacy a particular patient based on pre-implantation data, which lead unnecessary surgery and improper allocation financial resources. The principal aim PRediction vagal EfficaCy...
Post-heart transplant patients are at increased risk of diastolic dysfunction. The aim this study was to assess the prevalence isolated only exercise-induced heart failure with normal ejection fraction (HFNEF) in recipients.To determine pulmonary capillary wedge pressure (PCWP) rest and during exercise, 81 after orthotopic transplantation left ventricular (LVEF) underwent exercise right catheterization simultaneous echocardiography. Based on PCWP values, were divided into three groups....
Colorectal cancer (CRC) remains a major health burden. Although screening is recommended and considered beneficial, further data on its positive effects are needed for worldwide implementation.The aim of our national multicentre prospective observational study was to reveal document clinicopathological differences in CRC diagnosed by presented disease symptoms as well assess the efficiency programme Czech Republic.Between March 2013 September 2015, total 265 patients were enrolled 12...
Relevance . Caries of hard dental tissues is one the most common diseases throughout world. It affects not only primary teeth children, but also permanent adults, which can lead to serious consequences for human health. In recent years, community has paid special attention possible connection between streptococcal infection and development caries, therefore this topic extremely relevant requires detailed consideration. Chronic rheumatoid arthritis (CRA) joint diseases, characterized by...
Aim: To evaluate the association between computed tomography parameters and clinical signs in patients with acute pulmonary embolism. Methods: 109 retrospectivelly selected from hospital database embolism verified by CT angiography. The following were assessed: artery diameter to aorta ratio (PA/Ao), normalized (nPA), right ventricular left (RV CT/LV CT), end-diastolic (nRVD echo) end diastolic echo/LV echocardiography. Results: Multivariate regression analysis showed a significant PA/Ao...
Macitentan is a clinically approved endothelin receptor antagonist for the treatment of pulmonary arterial hypertension (PAH). Increasing use combination drug therapy in PAH means that it important to recognize potential drug-drug interactions (DDIs) could affect efficacy and safety macitentan patients with PAH.Two Phase 1 studies were conducted investigate effect at steady-state on pharmacokinetics breast cancer resistance protein (BCRP) substrates, rosuvastatin riociguat healthy male...
Abstract Background Fingolimod, an oral sphingosine 1-phosphate receptor immunomodulator, is approved in Europe for people with multiple sclerosis (pwMS) highly active disease despite a full and adequate course of treatment ≥ 1 disease-modifying therapy or patients rapidly evolving severe relapsing–remitting MS. GOLEMS, national, multicenter, non-interventional, single-arm, real-world study showed favorable benefit–risk profile 12-month fingolimod pwMS the Czech Republic. Here, we evaluated...
To determine the impact of HLA compatibility measured by Compatibility Index, on survival, rate rejections, malignancies and infections in patients after heart transplantation (HTx).We carried out a retrospective analysis 182 consecutive who underwent our center from January 2001 to April 2010. According degree HLA-A, B DR matching (Compatibility CI) were divided two groups, Group A (n=83) with an IC 0-17 group (n=99) 18-26. There was no significant difference demographic parameters between...
Purpose: A national primary and secondary healthcare-level study in the Czech Republic has not yet been conducted to evaluate prevalence of migraine. We analyzed current treatment patterns (acute prophylactic) migraine patients number potentially eligible for with recent calcitonin gene-related peptide (CGRP) pathway-targeted therapies. Methods: This retrospective utilized Ministry Interior Health Insurance Fund claims database wherein every citizen is insured. Migraine or without aura, on...