A5073990945- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Gene expression and cancer classification
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Bariatric Surgery and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- CRISPR and Genetic Engineering
- Organ Transplantation Techniques and Outcomes
- DNA Repair Mechanisms
- Neuroendocrine Tumor Research Advances
- BRCA gene mutations in cancer
- Eosinophilic Esophagitis
- Minimally Invasive Surgical Techniques
- IgG4-Related and Inflammatory Diseases
Institute of Clinical and Experimental Medicine
2015-2024
Czech Academy of Sciences, Institute of Animal Physiology and Genetics
2019-2021
University Hospital Olomouc
2021
St. Antonius Ziekenhuis
2021
University Medical Center Utrecht
2021
Palacký University Olomouc
2021
Prague University of Economics and Business
2016
Asian Institute of Gastroenterology
2013
Johns Hopkins University
2006-2009
Heidelberg University
2004-2009
This Guideline is an official statement of the European Society Gastrointestinal Endoscopy (ESGE). It addresses diagnosis and management nonvariceal upper gastrointestinal hemorrhage (NVUGIH). <b>Main Recommendations</b> <b>MR1.</b> ESGE recommends immediate assessment hemodynamic status in patients who present with acute (UGIH), prompt intravascular volume replacement initially using crystalloid fluids if instability exists (strong recommendation, moderate quality evidence). <b>MR2.</b> a...
This Guideline is an official statement of the European Society Gastrointestinal Endoscopy (ESGE). It addresses removal foreign bodies in upper gastrointestinal tract adults. <b>Recommendations</b> <b>Nonendoscopic measures</b> <b>1</b> ESGE recommends diagnostic evaluation based on patient’s history and symptoms. a physical examination focused general condition to assess signs any complications (strong recommendation, low quality evidence). <b>2</b> does not recommend radiological for...
MAIN RECOMMENDATION 1 ESGE suggests using contrast-enhanced computed tomography (CT) as the first-line imaging modality on admission when indicated and up to 4th week from onset in absence of contraindications. Magnetic resonance (MRI) may be used instead CT patients with contraindications CT, after invasive intervention is considered because contents (liquid vs. solid) pancreatic collections are better characterized by MRI evaluation duct integrity possible. Weak recommendation, low quality...
1: ESGE recommends the use of endoscopic ultrasound-guided biliary drainage (EUS-BD) over percutaneous transhepatic (PTBD) after failed retrograde cholangiopancreatography (ERCP) in malignant distal obstruction when local expertise is available.Strong recommendation, moderate quality evidence. 2: suggests EUS-BD with hepaticogastrostomy only for inoperable hilar a dilated left hepatic duct inadequately drained by ERCP and/or PTBD high volume expert centers.Weak 3: that EUS-guided pancreatic...
Main Recommendations 1 ESGE recommends that patients with compensated advanced chronic liver disease (ACLD; due to viruses, alcohol, and/or nonobese [BMI < 30 kg/m2] nonalcoholic steatohepatitis) and clinically significant portal hypertension (hepatic venous pressure gradient [HVPG] > 10 mmHg stiffness by transient elastography 25 kPa) should receive, if no contraindications, nonselective beta blocker (NSBB) therapy (preferably carvedilol) prevent the development of variceal...
1: ESGE recommends a prolonged course of prophylactic broad-spectrum antibiotic in patients with ascites who are undergoing therapeutic endoscopic ultrasound (EUS) procedures.Strong recommendation, low quality evidence. 2: placement partially or fully covered self-expandable metal stents during EUS-guided hepaticogastrostomy for biliary drainage malignant disease.Strong moderate 3: pancreatic duct (PD) should only be performed high volume expert centers, owing to the complexity this...
1: ESGE recommends that, where there is a suspicion of eosinophilic esophagitis, at least six biopsies should be taken, two to four from the distal esophagus and proximal esophagus, targeting areas with endoscopic mucosal abnormalities. Distal placed in separate containers.Strong recommendation, low quality evidence. 2: obtaining biopsies, including base edge esophageal ulcers, for histologic analysis patients suspected viral esophagitis.Strong 3: are taken cases advanced cancer gastric...
Histological examination of core tissue samples may have advantages over cytology in endoscopic ultrasound (EUS)-guided sampling. We aimed to evaluate the feasibility and efficiency a new 22G biopsy needle.Consecutive patients with pancreatic mass lesion or peri-intestinal lymphadenopathy sequentially underwent fine needle both newly developed (the FNB needle) standard aspiration (FNA) needle, randomized order.In 144 patients, mean age 48 years (± deviation [SD] 14; range 18 - 82), 145...
Background & AimsFecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA (miRNA) profiles as biomarkers noninvasive CRC diagnosis.MethodsA total of 1273 small RNA sequencing experiments were performed multiple biospecimens. a cross-sectional study, miRNA investigated fecal samples from an Italian and Czech cohort (155 CRCs, 87 adenomas, 96 other...
This joint ASGE-ESGE guideline provides an evidence-based summary and recommendations regarding the role of endoscopic bariatric metabolic therapies (EBMTs) in management obesity. The document was developed using Grading Recommendations, Assessment, Development Evaluation (GRADE) framework. It evaluates efficacy safety EBMT devices procedures that currently have CE mark or FDA-clearance/approval, had been approved within five years development. suggests use EBMTs plus lifestyle modification...
Background and aims Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology manifestations. Our were to characterize type 1 AIP in a large pan-European cohort study effectiveness current treatment regimens. Methods We retrospectively analyzed adults diagnosed since 2005 or not-otherwise-specified 42 European university hospitals. Type was uniformly using specific diagnostic criteria. Patients 2 those who had undergone pancreatic surgery...
The European Society of Gastrointestinal Endoscopy (ESGE) and United Gastroenterology (UEG) have a vision to create thriving community endoscopy services across Europe, collaborating with each other provide high quality, safe, accurate, patient-centered accessible endoscopic care. Whilst the boundaries what can be achieved by advanced are continually expanding, we believe that one most fundamental steps achieving our goal is raise quality everyday endoscopy. development robust, consensus-...
The European Society of Gastrointestinal Endoscopy (ESGE) and United Gastroenterology (UEG) have a vision to create thriving community endoscopy services across Europe, collaborating with each other provide high quality, safe, accurate, patient‐centered accessible endoscopic care. Whilst the boundaries what can be achieved by advanced are continually expanding, we believe that one most fundamental steps achieving our goal is raise quality everyday endoscopy. development robust, consensus‐...
Recommendations 1 ESGE suggests performing segmental biopsies (at least two from each segment), which should be placed in different specimen containers (ileum, cecum, ascending, transverse, descending, and sigmoid colon, rectum) patients with clinical endoscopic signs of colitis. Weak recommendation, low quality evidence. 2 recommends taking the right hemicolon (ascending transverse colon) and, a separate container, left (descending when microscopic colitis is suspected. Strong 3 pancolonic...
Background Endoluminal radiofrequency ablation (RFA) has been promoted as palliative treatment for patients with cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC) in order to improve biliary drainage eventually prolong survival. No high level evidence is, however, available on this technique. Design In randomised controlled study, we compared endoluminal RFA plus stenting alone (control group) malignant obstruction; metal stents were primarily placed. Primary outcome was...
Abstract Recent advances in oligonucleotide arrays and whole-genome complexity reduction data analysis now permit the evaluation of tens thousands single-nucleotide polymorphisms simultaneously for a genome-wide allelic status. Using these arrays, we created high-resolution allelotype maps 26 pancreatic cancer cell lines. The areas heterozygosity implicitly served to reveal regions loss. array-derived were verified by panel 317 microsatellite markers used subset seven samples, showing 97.1%...
Abstract The enormous scope of natural human genetic variation is now becoming defined. To accurately annotate these variants, and to identify those with clinical importance, often difficult assess through functional assays. We explored systematic annotation by using homologous recombination modify a native gene in hemizygous (wt/Δexon) cancer cells, generating novel syngeneic variance library (SyVaL). created SyVaL BRCA2 variants: nondeleterious, proposed deleterious, uncertain...
Steatosis occurs frequently after liver transplantation (LT). We aimed to determine the prevalence of steatosis in adult LT recipients, effects significant (>33%; grades 2-3) on patient survival, and identify risk factors for development its effect fibrosis progression. retrospectively examined 2360 posttransplant biopsies 548 recipients. Survival was compared between patients with those 0-1 steatosis. Patients were controls without (grade 0) clinical laboratory found 309 (56.4%) patients,...
Abstract Identification of genes with cancer-specific overexpression offers the potential to efficiently discover activities in an unbiased manner. We apply this paradigm study mesothelin (MSLN) overexpression, a nearly ubiquitous, diagnostically and therapeutically useful characteristic pancreatic cancer. identified 18-bp upstream enhancer, termed CanScript, strongly activating transcription from otherwise weak tissue-nonspecific promoter operating selectively cells having aberrantly...