A5088883227- Pancreatitis Pathology and Treatment
- Antifungal resistance and susceptibility
- Hemodynamic Monitoring and Therapy
- Agricultural Innovations and Practices
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Rangeland Management and Livestock Ecology
- Gastrointestinal disorders and treatments
- Sepsis Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
- Nosocomial Infections in ICU
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Renal function and acid-base balance
- Cardiac, Anesthesia and Surgical Outcomes
- Thermal Regulation in Medicine
- Gastric Cancer Management and Outcomes
- Agriculture and Rural Development Research
- Long-Term Effects of COVID-19
- Mechanical Circulatory Support Devices
Klinikum rechts der Isar
2015-2024
Technical University of Munich
2015-2024
LMU Klinikum
2018-2024
University of Bonn
2015-2023
München Klinik
2018-2023
Ludwig-Maximilians-Universität München
2014
Adoption and diffusion of digital farming technologies are expected to help transform current agricultural systems towards sustainability. To enable steer transformation we need understand the mechanisms adoption holistically. Our understanding is mainly informed by empirical farm-level studies agent-based models simulating systemic mechanisms. These two approaches weakly integrated. objective build an empirically grounded conceptual framework for synthesizing literature on these alternative...
Background Superinfections, including invasive pulmonary aspergillosis (IPA), are well-known complications of critically ill patients with severe viral pneumonia. Aim this study was to evaluate the incidence, risk factors and outcome IPA in COVID-19 Methods We prospectively screened 32 pneumonia for a time period 28 days using standardized protocol oberservation developement associated (CAPA). collected laboratory, microbiological, virological clinical parameters at defined timepoints...
Background and aims Autoimmune pancreatitis (AIP) is an immune-mediated disease of the pancreas with distinct pathophysiology manifestations. Our were to characterize type 1 AIP in a large pan-European cohort study effectiveness current treatment regimens. Methods We retrospectively analyzed adults diagnosed since 2005 or not-otherwise-specified 42 European university hospitals. Type was uniformly using specific diagnostic criteria. Patients 2 those who had undergone pancreatic surgery...
Linstädter, A., A. Kuhn, C. Naumann, S. Rasch, Sandhage-Hofmann, W. Amelung, J. Jordaan, Du Preez, and M. Bollig. 2016. Assessing the resilience of a real-world social-ecological system: lessons from multidisciplinary evaluation South African pastoral system. Ecology Society 21(3):35.http://dx.doi.org/10.5751/ES-08737-210335
The clinical and immunological impact of B-cell depletion in the context coronavirus disease 2019 (COVID-19) is unclear. We conducted a prospectively planned analysis COVID-19 patients who received depleting anti-CD20 antibodies chemotherapy for lymphomas. control cohort consisted age- sex-matched without lymphoma were hospitalized because COVID-19. performed detailed analyses, in-depth cellular molecular immune profiling, comprehensive virological studies 12 with available biospecimens....
Objective Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis—Microbiome As Predictor Severity; P-MAPS) early at hospital admission. Design Buccal and rectal microbial swabs were collected from 424 patients with within 72 hours admission 15 European centres. All samples sequenced by full-length 16S rRNA metagenomic sequencing using Oxford Nanopore Technologies. Primary endpoint was...
Necrotising pancreatitis, and particularly infected necrosis, are still associated with high morbidity mortality. Since 2011, a step-up approach lower rates compared to initial open necrosectomy has been established. However, mortality complication of this complex treatment hardly studied thereafter.The German Pancreatitis Study Group performed multicenter, retrospective study including 220 patients necrotising pancreatitis requiring intervention, treated at 10 hospitals in Germany between...
Introduction Spontaneous peritonitis, especially spontaneous fungal peritonitis (SFP), is an important and potentially fatal complication in patients with endstage liver disaese. We evaluated potential risk factors, microbiological findings, outcome of SFP compared to bacterial (SBP) critically ill patients. Methods Retrospective analyses suspected peritonitis. Results Out 205 patients, 20 (10%) had SFP, 28 (14%) SBP, 48 (24%) without findings (SP) 109 (52%) no-peritonitis (NP). APACHE II...
Background Early recognition of high-risk-patients with acute respiratory distress syndrome (ARDS) might improve their outcome by less protracted allocation to intensified therapy including extracorporeal membrane oxygenation (ECMO). Among numerous predictors and classifications, the American European Consensus Conferenece (AECC)- Berlin-definitions as well index (OI) Murray-/Lung Injury Score are most common. Most studies compared prediction mortality these parameters on day intubation...
Visualization of B-lines via lung ultrasound provides a non-invasive estimation pulmonary hydration. Extravascular water index (EVLWI) and vascular permeability (PVPI) assessed by transpulmonary thermodilution (TPTD) represent the most validated parameters alveolocapillary permeability, but measurement is invasive expensive. This study aimed to compare correlations scores from extensive 28-sector simplified 4-sector chest scan with EVLWI PVPI derived TPTD in setting intensive care unit...
Outcome of severe acute pancreatitis (SAP) highly depends on the degree systemic inflammation and organ failure. Although treatment approaches targeting inflammatory cascade have failed in pancreatitis, recent studies suggest that extracorporeal cytokine adsorption effectively reduces concentrations pro-inflammatory cytokines potentially improves outcome sepsis.Sixteen patients with SAP, presenting within 7 days upon onset pain, an APACHE-II score ≥10 ≥1 marker poor prognosis, received 2...
The clinical spectrum of acute SARS-CoV-2 infection ranges from an asymptomatic to life-threatening disease. Considering the broad severity, reliable biomarkers are required for early risk stratification and prediction outcomes. Despite numerous efforts, no COVID-19-specific biomarker has been established guide further diagnostic or even therapeutic approaches, most likely due insufficient validation, methodical complexity, economic factors. COVID-19-associated coagulopathy is a hallmark...
Background Pancreatic pseudocysts arise mostly in patients with alcohol induced chronic pancreatitis causing various symptoms and complications. However, data on the optimal management are rare. To address this problem, we analysed pancreatic treated at our clinic retrospectively. Methods We searched clinical database for diagnosis from 2004 till 2014, selected larger than 10 mm entered all relevant information a statistical analysis. Results In total, 129 were institution during study...
Chronic pancreatitis (CP) is a fibrotic disorder of the pancreas leading to clinical sequelae like pain and an excess comorbidity including cardiovascular disease cancers. The aim this study was determine relationship between systemic inflammation quality life in patients with CP. Patients were prospectively recruited underwent assessment (EORTC QLQ-C30 PAN 28). serum inflammatory profile assessed using MSD 30-plex array. variables, cytokines determined by GLM-MANOVA individual impact...
Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity/mortality in critically ill patients with endstage liver disease. Therefore, aim this study to predict the prevalence and outcome IPA underlying cirrhosis evaluation necessity Glactomannan (GM) screening serum bronchoalveolar lavage (BAL) cohort. In total 12 out 84 (14%) had probable IPA. The mean optical density index (ODI) GM was 3.6 ± 1.5 (Range: 1.7-5.7). An overall sensitivity 90% (95% CI 86-96%) specificity 85%...
We present rare, empirical evidence on the permanence of land use changes induced by a payments for ecosystem services (PES) program. A follow-up study was conducted decade after end Regional Integrated Silvo-pastoral Ecosystem Management Project (RISEMP) in Costa Rica. Econometric analysis found that silvo-pastoral practices persisted long term and are not reverted. On average there is also no meaningful intensification ceased. However, some heterogeneity individual level. find farms...
Sepsis is as a life-threatening organ dysfunction caused by dysregulated host response to an infection. The mortality of sepsis and particular septic shock very high. Treatment mostly focuses on infection control but specific intervention that targets the underlying pathological lacking present time. investigators hypothesize early therapeutic plasma exchange (TPE) will dampen maladaptive removing injurious mediators thereby limiting improving survival in patients with shock. Although small...