Dominik Jarczak
A5057618004- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Antibiotics Pharmacokinetics and Efficacy
- Hepatitis C virus research
- Dialysis and Renal Disease Management
- COVID-19 Impact on Reproduction
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Adrenal Hormones and Disorders
- Vitamin C and Antioxidants Research
- Tracheal and airway disorders
- Stress Responses and Cortisol
- RNA and protein synthesis mechanisms
- Airway Management and Intubation Techniques
- RNA modifications and cancer
- Hemodynamic Monitoring and Therapy
- SARS-CoV-2 detection and testing
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
Ludwig-Maximilians-Universität München
2025
München Klinik
2025
LMU Klinikum
2025
Schön Klinik Bad Aibling
2025
German Center for Infection Research
2024
University of Bologna
2023
Martini-Klinik
2017-2022
Universitätsmedizin Göttingen
2021
Septic shock, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is highly lethal condition that causes substantial morbidity and mortality among critically ill patients. One of the hallmarks sepsis excessive release cytokines other inflammatory mediators causing refractory hypotension, tissue damage, metabolic acidosis ultimately multiple failure. In this context, cytokine reduction hemoadsorption represents new concept for blood purification,...
Although current guidelines suggest the use of regional citrate anticoagulation (which involves addition a solution to blood before filter extracorporeal dialysis circuit) as first-line treatment for continuous kidney replacement therapy in critically ill patients, evidence this recommendation is based on few clinical trials and meta-analyses.To determine effect anticoagulation, compared with systemic heparin life span mortality.A parallel-group, randomized multicenter trial 26 centers...
Tissue-resident memory-like T H 17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.
Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. Randomized, multicenter, controlled trial from January 2017 to December 2019. Adult patients (n = 254) sepsis or septic shock were randomly assigned 1:1 receive continuous infusion of piperacillin/tazobactam dosing guided by daily TDM piperacillin a fixed dose (13.5 g/24 h if eGFR ≥ 20 mL/min). Target plasma...
There are large uncertainties with regard to the outcome of patients coronavirus disease 2019 (COVID-19) and mechanical ventilation (MV). High mortality (50-97%) was proposed by some groups, leading considerable outcomes critically ill COVID-19.
Summary Males develop more severe SARS-CoV-2 infection related disease outcome than females. Herein, sex hormones were repeatedly proposed to play an important role in Covid-19 pathophysiology and immunity. However, it is yet unclear whether are associated with males In this study, we analyzed hormones, cytokine chemokine responses as well performed a large profile analysis of 600 metabolites critically-ill male female patients comparison healthy controls coronary heart diseases prime...
Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether hormones are associated with disease severity in COVID-19 patients. In this study, we analysed hormone levels (estradiol testosterone) of male female patients (n = 50) admitted to an unit (ICU) comparison control non-COVID-19 at the ICU 42), most prevalent comorbidity (coronary heart diseases) present within cohort 39) healthy individuals 50). We detected...
While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons seasonal influenza are scarce. We compared 166 COVID-19 diagnosed between February 27 and June 14, 2020, 255 during 2017-18 season at same hospital to describe common features differences in characteristics disease. Patients were younger (median age [IQR], 59 [45-71] vs 66 [52-77]; P < 0001) had fewer comorbidities baseline a lower mean overall age-adjusted...
We here investigate the impact of antiviral treatments such as remdesivir on intra-host genomic diversity and emergence SARS-CoV2 variants in patients with a prolonged course infection. Sequencing variant analysis performed 112 longitudinal respiratory samples from 14 SARS-CoV2-infected severe disease progression show that major frequency do not generally arise during However, treatment can increase result novel species harboring fixed mutations. This is particularly evident patient B cell...
To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk invasive Candida infection (ICI). Multicenter, randomized, controlled trial carried out between September 2016 2019 in 18 intensive care units enrolling adult at for ICI. Patients the control group received targeted driven by culture results. In addition therapy, BDG antifungals if least one two consecutive samples taken during first...
Severe COVID-19 induced acute respiratory distress syndrome (ARDS) often requires extracorporeal membrane oxygenation (ECMO). Recent German health insurance data revealed low ICU survival rates. Patient characteristics and experience of the ECMO center may determine intensive care unit (ICU) survival. The current study aimed to identify factors affecting patients.673 ARDS patients treated in 26 centers between January 1st 2020 March 22nd 2021 were included. Data on clinical characteristics,...
We performed an analysis of two blood purification systems to determine their performance for removing interleukins (ILs)-6 and 10, tumor necrosis factor (TNF)-α monocyte chemoattractant protein (MCP)-1 from blood.An in vitro hemoperfusion recirculation circuit was used compare the CytoSorb® 300 mL (CytoSorbents Inc., Princeton, NJ) Jafron HA 380 (Jafron Biomedical Co., Ltd., Zhuhai City, China) devices. The removal purified recombinant human IL-6, IL-10, TNFα MCP-1 by adsorbers compared at...
Abstract Purpose The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. aim study was verify functionality correlates a recently developed PCS score. Methods score applied prospective, multi-center cross-sectoral cohort (in- outpatients with SARS-CoV-2 infection) "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment patient-reported outcome measure questionnaires were analyzed at 3 12 months...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), an emerging virus, has caused a global pandemic. Coronavirus disease 2019 (COVID-19), by SARS-CoV-2, led to high hospitalization rates worldwide. Little is known about the occurrence of in-hospital cardiac arrest (IHCA) and mortality have been proposed. The aim this study was investigate incidence, characteristics outcome IHCA during pandemic in comparison earlier period.This retrospective analysis data prospectively recorded...
Introduction: Despite advances in critical care medicine, adjunctive approaches sepsis therapy have failed to prove their efficacy. Notwithstanding promising results using hemoadsorption (CytoSorb), questions remain concerning timing and dosing. We created a dynamic scoring system (DSS) assess patients with early septic shock performed first evaluation of the this patient population. Methods: Data from 502 according Sepsis-3 criteria were retrospectively analyzed. Score parameters documented...
Carbapenem-resistant Acinetobacter baumannii infections are difficult to treat and a significant public health threat due intrinsic/acquired resistance limited treatment options.A retrospective, observational cohort study in patients receiving cefiderocol via Shionogi's early access program for spp (1 April 2020-30 2021; 27 sites; Italy, Spain, Germany, France). Primary outcome was clinical success, defined as resolution of infection at day 14 or 28 survival.Overall, 147 were included. sites...
Abstract Background Approximately 20–25% of patients who survive medical treatment at an intensive care unit (ICU) develop post-traumatic stress symptoms. There is currently a gap in follow-up for them. As part the PICTURE study, general practitioners (GPs) carried out brief interview-based intervention. The aim this sub-study to record most distressing memories ICU from patient’s perspective and their evaluation GP-based psychological Methods Participants were recruited intervention group...
Background Several case series have highlighted the ADVOS hemodialysis system's efficacy in eliminating water-soluble and protein-bound substances across diverse patient populations, such as multiorgan failure, acute-on-chronic liver failure (ACLF), acidosis, even COVID-19. The EMOS-Registry, a non-interventional, multi-center registry, amassed real-world evidence, culminating largest cohort treated with to date. This study aims present analyze final performance safety outcomes from entire...
Abstract Objectives Nirmatrelvir/ritonavir is recommended for high-risk patients with COVID-19 to reduce disease progression and mortality. Ritonavir significantly increases the bioavailability of nirmatrelvir most potent irreversible cytochrome P 450 3A4 inhibitor in clinical use, resulting a substantial risk drug-drug interactions (DDI). We aimed analyze incidence potential DDI (pDDI) critically ill SARS-CoV-2 infection. Methods This retrospective single-center study quaternary care center...