Alessandro Bartoloni
A5101854978- Parasites and Host Interactions
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Parasitic infections in humans and animals
- Antibiotic Use and Resistance
- Malaria Research and Control
- Parasite Biology and Host Interactions
- Antibiotics Pharmacokinetics and Efficacy
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Epilepsy research and treatment
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Tuberculosis
- Pharmacological Effects and Toxicity Studies
- Global Maternal and Child Health
- Parasitic Infections and Diagnostics
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Travel-related health issues
University of Florence
2016-2025
Azienda Ospedaliero-Universitaria Careggi
2016-2025
Regione Toscana
2016-2024
University of Bologna
2023
Hospital for Tropical Diseases
2017-2022
University of Genoa
2022
Jackson and Tull (United States)
2022
Kindai University
2022
Istituto Neurologico Mediterraneo
2020
Hospital General Universitario Gregorio Marañón
2019
BACKGROUND. Coronavirus disease 19 (COVID-19) is an emerging infectious caused by SARS-CoV-2. Antiviral immune response crucial to achieve pathogen clearance; however, in some patients excessive and aberrant host can lead acute respiratory distress syndrome. The comprehension of the mechanisms that regulate elimination, immunity, pathology essential better characterize progression widen spectrum therapeutic options.
The first symptoms of malaria, common to all the different malaria species, are nonspecific and mimic a flu-like syndrome. Although fever represents cardinal feature, clinical findings in extremely diverse may range severity from mild headache serious complications leading death, particularly falciparum malaria. As progression these can be rapid, any patient must assessed treated rapidly, frequent observations needed look for early signs systemic complications.In fact, severe is life...
How is the semen quality of sexually active men following recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection?Twenty-five percent with recent SARS-Cov-2 infections and proven healing were oligo-crypto-azoospermic, despite absence virus RNA in semen.The presence SARS-CoV-2 human its role contagion after disease 2019 (COVID-19) still unclear. So far, studies evaluating occurrence infected or recovered are scarce included a limited number participants.A...
We report a case of Zika virus infection imported in Florence, Italy ex-Thailand, leading to secondary autochthonous case, probably through sexual transmission. The two cases occurred May 2014 but were retrospectively diagnosed 2016 on the basis serological tests (plaque reduction neutralisation) performed stored serum samples. Our provides further evidence that transmission is possible.
The characterization of the adaptive immune response to COVID-19 vaccination in individuals who recovered from SARS-CoV-2 infection may define current and future clinical practice. To determine effect 2-dose BNT162b2 mRNA schedule (COVID-19–recovered subjects) compared with naive subjects, we evaluated Spike–specific T B cell responses, as well specific IgA, IgG, IgM, neutralizing antibodies titers 22 received vaccine, 11 whom had a previous history infection. Evaluations were performed...
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
ABSTRACT A survey carried out in 2005 among members of a healthy population children living Bolivia and Peru revealed that fecal carriage Escherichia coli strains resistant to expanded-spectrum cephalosporins was remarkably increased compared observed the same settings 2002 (1.7% versus 0.1% 2002). In this work, we demonstrated phenomenon mainly related dissemination CTX-M-type extended-spectrum β-lactamase (ESBL) determinants commensal E. strains. Of 50 ESBL-producing isolates collected...
Screening for active tuberculosis (TB) and latent TB infection (LTBI) is mandatory prior to the initiation of tumour necrosis factor-alpha inhibitor therapy. However, no agreement exists on best strategy detecting LTBI in this population. The aim present study was analyse performance tuberculin skin test (TST) QuantiFERON-TB Gold in-tube (QFT-GIT) detection subjects with immunomediated inflammatory diseases (IMID). TST QFT-GIT were prospectively performed 398 consecutive IMID subjects, 310...
Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, fever resembles dengue fever, but less severe. Whereas clinical syndrome laboratory diagnostic procedures have been described, little attention was paid to immunology of disease its possible use for follow-up patients. Here, we investigate role cytokines pathogenesis travelers returning from Asia, Pacific, Polyfunctional T cell activation (Th1, Th2, Th9,...
We report a case of laboratory-confirmed Zika virus infection imported into Europe from the Americas. The patient developed fever, rash, and oedema hands feet after returning to Italy Brazil in late March 2015. highlights that, together with chikungunya dengue virus, three major arboviruses are now co-circulating Brazil. These represent burden for healthcare systems other countries where competent mosquito vectors present.
Abstract Introduction A hypercoagulable condition was described in patients with coronavirus disease 2019 (COVID-19) and proposed as a possible pathogenic mechanism contributing to progression lethality. Aim We evaluated if in-hospital administration of heparin improved survival large cohort Italian COVID-19 patients. Methods In retrospective observational study, 2,574 unselected hospitalized 30 clinical centers Italy from February 19, 2020 June 5, laboratory-confirmed severe acute...
The current pandemic emergence of novel coronavirus disease (COVID-19) poses a relevant threat to global health. SARS-CoV-2 infection is characterized by wide range clinical manifestations, ranging from absence symptoms severe forms that need intensive care treatment. Here, plasma-EDTA samples 30 patients compared with age- and sex-matched controls were analyzed via untargeted nuclear magnetic resonance (NMR)-based metabolomics lipidomics. With the same approach, effect tocilizumab...
During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches be needed. We present case of 36-year-old kidney-transplanted woman affected by Senior-Loken syndrome diagnosed with COVID-19 pneumonia after contact her positive mother. Initial symptoms were fatigue, dry cough, coryza; she never had...
Objectives Several physiological abnormalities that develop during COVID-19 are associated with increased mortality. In the present study, we aimed to a clinical risk score predict in-hospital mortality in patients, based on set of variables available soon after hospitalisation triage. Setting Retrospective cohort study 516 patients consecutively admitted for two Italian tertiary hospitals located Northern and Central Italy were collected from 22 February 2020 (date first admission) 10 April...
SARS-CoV-2 is responsible for a new infectious disease (COVID-19) in which individuals can either remain asymptomatic or progress from mild to severe clinical conditions including acute respiratory distress syndrome and multiple organ failure. The immune mechanisms that potentially orchestrate the pathology infection are complex only partially understood. There still paucity of data on features myeloid cells involved this viral infection. For reason, we investigated different activation...
Abstract Overwhelming inflammatory reactions contribute to respiratory distress in patients with COVID-19. Ruxolitinib is a JAK1/JAK2 inhibitor potent anti-inflammatory properties. We report on prospective, observational study 34 COVID-19 who received ruxolitinib compassionate-use protocol. Patients had severe pulmonary disease defined by infiltrates imaging and an oxygen saturation ≤ 93% air and/or PaO2/FiO2 ratio 300 mmHg. Median age was 80.5 years, 85.3% ≥ 2 comorbidities. exposure time...