A5017896785- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Kawasaki Disease and Coronary Complications
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- SARS-CoV-2 detection and testing
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Long-Term Effects of COVID-19
- Neonatal and Maternal Infections
- Cystic Fibrosis Research Advances
- Antibiotic Resistance in Bacteria
- Coronary Artery Anomalies
- Vaccine Coverage and Hesitancy
- Mechanical Circulatory Support Devices
- Antifungal resistance and susceptibility
- COVID-19 Impact on Reproduction
- Infective Endocarditis Diagnosis and Management
- vaccines and immunoinformatics approaches
- Inflammasome and immune disorders
- Antibiotic Use and Resistance
National and Kapodistrian University of Athens
2016-2025
Children's Hospital Agia Sophia
2014-2024
Children's Hospital
2023
Czech Academy of Sciences, Institute of Microbiology
2023
Iaso Children’s Hospital
2021-2022
University Hospital Cologne
2021
Hellenic Center for Disease Control & Prevention
2015
Athens State University
2010
Beth Israel Deaconess Medical Center
2008
Harvard University
2006-2007
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only three, plus IFN-ω five, and IFN-α2, IFN-β two; nine patients). Seven (3.8%) Abs at least ng/ml one IFN, whereas the other 12 (6.6%) 100 pg/ml. The auto-Abs neutralized both unglycosylated glycosylated IFNs. also detected pg/ml 4 2,267 uninfected (0.2%) 45 (2%). odds ratios (ORs) life-threatening were, therefore,...
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
Non-polio human enteroviruses are the leading cause of aseptic meningitis in children. The role enterovirus PCR for diagnosis and management has not been fully explored.A retrospective study was conducted to determine epidemiological, clinical, laboratory characteristics evaluate this clinical entity. medical records children who had as discharge or viral were reviewed. A total 506 children, median age 5 years, identified. annual incidence rate estimated be 17/100,000 less than 14 years age....
There is limited information on severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection in children.We retrieved data from the national database SARS-CoV-2 infections. We studied in-family transmission. The level of viral load was categorized as high, moderate, or low based cycle threshold values.We 203 SARS-CoV-2-infected children (median age: 11 years; range: 6 days to 18.4 years); 111 (54.7%) had an asymptomatic infection. Among 92 (45.3%) with coronavirus disease 2019...
Acquisition of multiple carbapenemase genes by Klebsiella pneumoniae (Kp) is an emerging public health threat. Here, we aim to elucidate the population structure Kp blood isolates carrying two different and identify mechanism facilitating their dissemination. The study was conducted in a tertiary healthcare center between 2014 2022. Twenty-four patients with bacteremia caused were identified. All 24 analyzed short-read genome sequences supplemented long reads selected number isolates....
Abstract Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe hyperinflammatory condition that may occur following SARS-CoV-2 infection. This retrospective, descriptive study of hospitalized with multisystem 12 tertiary care centers from 3/11/2020 to 12/31/2021. Demographics, clinical and laboratory characteristics, treatment outcomes are described. Among 145 patients (95 males, median age 8.2 years) included, 123 met the WHO criteria for MIS-C, while 112 (77%) had...
Streptolysin O (SLO) is a cholesterol-dependent cytolysin produced by the important human pathogen, group A Streptococcus (Streptococcus pyogenes or GAS). In addition to its cytolytic activity, SLO mediates translocation of GAS NAD-glycohydrolase (NADase) into epithelial cells in vitro. Production both NADase and associated with augmented host cell injury beyond that alone, but mechanism enhanced cytotoxicity not known. We have now shown expression together dramatically lytic activity...
The availability of antigen tests for SARS-CoV-2 represents a major step the mass surveillance incidence infection, especially regarding COVID-19 asymptomatic and/or early-stage patients. Recently, we reported development Bioelectric Recognition Assay-based biosensor able to detect S1 spike protein expressed on surface virus in just three minutes, with high sensitivity and selectivity. working principle was established by measuring change electric potential membrane-engineered mammalian...
Multisystem inflammatory syndrome in children (MIS-C), is a rare but severe, hyperinflammatory complication of COVID-19, which cardiovascular abnormalities are frequently detected. In this prospective study, we describe the echocardiographic findings patients with MIS-C, use conventional Echocardiography and Speckle-Tracking (STE) Left Ventricular (LV) Global Longitudinal Strain (GLS) analysis, acute follow-up phase. total, 25 MIS-C [64% females, mean (± SD) age: 8.3 3.72) years] were...
Clostridium difficile-associated colitis is an increasing cause of morbidity and mortality in hospitalized patients, with high relapse rates following conventional therapy. We sought to determine the efficacy rifaximin, a novel nonabsorbed antibiotic, hamster model C. diarrhea (CDAD). Hamsters received clindamycin subcutaneously 24 h later were infected by gavage one two difficile strains: reference strain (VPI 10463) current epidemic (BI17). Vancomycin (50 mg/kg body weight) or rifaximin...
Limited recent molecular epidemiology data are available for pediatric Central Nervous System (CNS) infections in Europe. The aim of this study was to investigate the enterovirus (EV) involved CNS children. Cerebrospinal fluid (CSF) from children (0–16 years) with suspected meningitis–encephalitis (ME) who were hospitalized largest hospital Greece October 2017 September 2020 initially tested 14 common pathogens using multiplex PCR FilmArray® ME Panel (FA-ME). CSF samples positive EV, as well...
Introduction: Data about compliance with perioperative antimicrobial prophylaxis (PAP) guidelines in the pediatric population are limited. This study aims to evaluate PAP adherence surgical subspecialty departments. Methods: A prospective cohort was conducted from September 2023 October 2024 at “Aghia Sophia” Children’s Hospital, Athens, Greece. Children <16 years old undergoing procedures neurosurgery (NS), orthopedics (OP), and otolaryngology (ORL) departments were included. on...
Abstract Background An increase in invasive Group A Streptococcus (iGAS) and non-invasive GAS cases has been reported worldwide, especially among children, since 2022. The aim of this study was the genetic characterization isolates pediatric population Greece. Methods from children with iGAS to National Public Health Organization (NPHO) a representative number infections were prospectively collected during 01-12/2023. Isolates examined for antimicrobial susceptibility Etest emm types...