A5063120585- Parasites and Host Interactions
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Parasitic infections in humans and animals
- SARS-CoV-2 and COVID-19 Research
- Parasite Biology and Host Interactions
- Long-Term Effects of COVID-19
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Global Maternal and Child Health
- Global Health Workforce Issues
- Dermatological diseases and infestations
- Travel-related health issues
- Herpesvirus Infections and Treatments
- Congenital Anomalies and Fetal Surgery
- Tuberculosis Research and Epidemiology
- Vector-borne infectious diseases
- Cytomegalovirus and herpesvirus research
- Zoonotic diseases and public health
- Parvovirus B19 Infection Studies
- Global Health and Surgery
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
University of Florence
2016-2025
Azienda Ospedaliero-Universitaria Careggi
2016-2025
Regione Toscana
2019-2024
National Centre for Disease Prevention and Control
2023
Meyer Children's Hospital
2015-2022
Hospital for Tropical Diseases
2020-2022
Istituto Superiore di Sanità
2016
Radboud University Nijmegen
2015
Radboud University Medical Center
2015
Institut Louis Malardé
2015
The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies patients with COVID-19 pneumonia a good safety profile.To evaluate the effect early tocilizumab administration vs standard therapy preventing clinical worsening hospitalized pneumonia.Prospective, open-label, randomized trial that between March 31 and June 11, 2020, to receive or care 24 hospitals Italy. Cases were confirmed by...
BACKGROUND. Coronavirus disease 19 (COVID-19) is an emerging infectious caused by SARS-CoV-2. Antiviral immune response crucial to achieve pathogen clearance; however, in some patients excessive and aberrant host can lead acute respiratory distress syndrome. The comprehension of the mechanisms that regulate elimination, immunity, pathology essential better characterize progression widen spectrum therapeutic options.
The first symptoms of malaria, common to all the different malaria species, are nonspecific and mimic a flu-like syndrome. Although fever represents cardinal feature, clinical findings in extremely diverse may range severity from mild headache serious complications leading death, particularly falciparum malaria. As progression these can be rapid, any patient must assessed treated rapidly, frequent observations needed look for early signs systemic complications.In fact, severe is life...
We report a case of Zika virus infection imported in Florence, Italy ex-Thailand, leading to secondary autochthonous case, probably through sexual transmission. The two cases occurred May 2014 but were retrospectively diagnosed 2016 on the basis serological tests (plaque reduction neutralisation) performed stored serum samples. Our provides further evidence that transmission is possible.
The characterization of the adaptive immune response to COVID-19 vaccination in individuals who recovered from SARS-CoV-2 infection may define current and future clinical practice. To determine effect 2-dose BNT162b2 mRNA schedule (COVID-19–recovered subjects) compared with naive subjects, we evaluated Spike–specific T B cell responses, as well specific IgA, IgG, IgM, neutralizing antibodies titers 22 received vaccine, 11 whom had a previous history infection. Evaluations were performed...
Zika virus is an emerging mosquito-borne flavivirus currently causing large epidemics in the Pacific Ocean region and Brazil. Clinically, fever resembles dengue fever, but less severe. Whereas clinical syndrome laboratory diagnostic procedures have been described, little attention was paid to immunology of disease its possible use for follow-up patients. Here, we investigate role cytokines pathogenesis travelers returning from Asia, Pacific, Polyfunctional T cell activation (Th1, Th2, Th9,...
We report a case of laboratory-confirmed Zika virus infection imported into Europe from the Americas. The patient developed fever, rash, and oedema hands feet after returning to Italy Brazil in late March 2015. highlights that, together with chikungunya dengue virus, three major arboviruses are now co-circulating Brazil. These represent burden for healthcare systems other countries where competent mosquito vectors present.
Schistosomiasis remains one of the most prevalent parasitic diseases worldwide and infection is frequently found in travelers migrants. The European Network for Tropical Medicine Travel Health conducted a sentinel surveillance study on imported schistosomiasis between 1997 2010. This report summarizes epidemiological clinical data from 1,465 cases schistosomiasis. Direct pathogen detection serology were main diagnostic tools applied. Of these, 486 (33%) identified among travelers, 231 (16%)...
Schistosomiasis is a neglected infection affecting millions of people, mostly living in sub-Saharan Africa. Morbidity and mortality due to chronic are relevant, although schistosomiasis often clinically silent. Different diagnostic tests have been implemented order improve screening diagnosis, that traditionally rely on parasitological with low sensitivity. Aim this study was evaluate the accuracy different for African migrants, non endemic setting.A retrospective conducted 373 patients...
Abstract Overwhelming inflammatory reactions contribute to respiratory distress in patients with COVID-19. Ruxolitinib is a JAK1/JAK2 inhibitor potent anti-inflammatory properties. We report on prospective, observational study 34 COVID-19 who received ruxolitinib compassionate-use protocol. Patients had severe pulmonary disease defined by infiltrates imaging and an oxygen saturation ≤ 93% air and/or PaO2/FiO2 ratio 300 mmHg. Median age was 80.5 years, 85.3% ≥ 2 comorbidities. exposure time...
Abstract Objective The aim of this study was to identify the main CT features that may help in distinguishing a progression interstitial lung disease (ILD) secondary SSc from COVID-19 pneumonia. Methods This multicentric included 22 international readers grouped into radiologist group (RADs) and non-radiologist (nRADs). A total 99 patients, 52 with 47 SSc-ILD, were study. Results Fibrosis inside focal ground-glass opacities (GGOs) upper lobes; fibrosis lower lobe GGOs; reticulations lobes...
Rationale Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus disease 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone addition standard treatment COVID-19 pneumonia. Methods In this multicentre, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with pneumonia were randomised receive 1 g intravenously for three consecutive days or placebo dexamethasone. The primary outcome was duration...
Although accumulating data have investigated the effect of SARS-CoV-2 mutations on antibody neutralizing activity, less is known about T cell immunity. In this work, we found that ancestral (Wuhan strain) Spike protein can efficaciously reactivate CD4+ memory in subjects with previous Alpha variant infection. This finding has practical implications, as many countries only one vaccine dose currently administered to individuals COVID-19, independently which was responsible We also a minority...
COVID-19 has been associated with a broad range of long-term sequelae, commonly referred to as “long-COVID” or “post-COVID-19” syndrome. Despite an increasing body literature, long COVID remains poorly characterized. We retrospectively analysed data from electronic medical records patients admitted the post-COVID-19 outpatient service Infectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy, between June 2020 2021, 4–12 weeks after hospital discharge. A total 428...
BACKGROUNDImmunization against SARS-CoV-2, the causative agent of COVID-19, occurs via natural infection or vaccination. However, it is currently unknown how long infection- vaccination-induced immunological memory will last.METHODSWe performed a longitudinal evaluation to SARS-CoV-2 up 1 year after and following mRNA vaccination in naive individuals recovered from COVID-19 infection.RESULTSWe found that cells are still detectable 8 months vaccination, while antibody levels decline...
The characterization of cell-mediated and humoral adaptive immune responses to SARS-CoV-2 is fundamental understand COVID-19 progression the development immunological memory virus. In this study, we detected T-cells reactive proteins M, S, N, as well serum virus-specific IgM, IgA, IgG, in nearly all infected individuals, but not healthy donors. Virus-reactive T cells exhibited signs vivo activation, suggested by surface expression immune-checkpoint molecules PD1 TIGIT. Of note,...
We analysed the first 84 coronavirus disease (COVID-19) patients hospitalised in an infectious and tropical unit Florence, Italy, over 30 days after start of COVID-19 outbreak Italy. A 12% reduction rate intensive care transfer was observed implementation intensity measures regular ward such as increasing nurse/patient ratio, presence critical physicians using high flow nasal cannulae oxygenation.