A5060169707- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Blood Coagulation and Thrombosis Mechanisms
- Folate and B Vitamins Research
- Coronary Interventions and Diagnostics
- Nutritional Studies and Diet
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Diabetes Treatment and Management
- Neurological Complications and Syndromes
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory mediators and NSAID effects
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Blood properties and coagulation
- Retinal Diseases and Treatments
Azienda Ospedaliero-Universitaria Careggi
2016-2025
University of Florence
2016-2025
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2021-2025
Azienda Sanitaria di Firenze
2024
Ospedale Santa Maria
2024
University of Padua
1994-2023
Center for Rheumatology
2023
European Atherosclerosis Society
2021
Orthopaedic Center
2021
Thrombosis Research Institute
2007-2021
Background— The clinical impact of platelet aggregation assessed by point-of-care assays is unknown. We sought to evaluate whether high residual reactivity (RPR) ADP during clopidogrel therapy, measured a assay, predicts adverse events in acute coronary syndrome patients undergoing percutaneous intervention. Methods and Results— used the VerifyNow P2Y12 assay (Accumetrics Inc, San Diego, Calif) determine RPR 683 with dual-antiplatelet therapy who underwent intervention bare-metal or...
High residual platelet reactivity (HRPR) in patients receiving clopidogrel has been associated with high risk of ischemic events after percutaneous coronary intervention (PCI).To test the hypothesis that HRPR loading is an independent prognostic marker long-term thrombotic acute syndromes (ACS) undergoing invasive procedure and antithrombotic treatment adjusted according to results function tests.Prospective, observational, referral center cohort study 1789 consecutive ACS PCI from April...
Only a few randomized dietary intervention studies that investigated the effects of lacto-ovo vegetarian diet (Vd) in clinically healthy omnivorous subjects are available.We randomly assigned to overweight omnivores with low-to-moderate cardiovascular risk profile low-calorie Vd compared Mediterranean (MD), each lasting 3 months, crossover design. The primary outcome was difference body weight, mass index, and fat changes between 2 groups. Secondary outcomes were differences circulating...
Heparin-induced thrombocytopenia (HIT) is a relatively rare condition burdened by high rate of complications and mortality. Cardiac surgery risk setting for this condition. But in area, some particularities can make both diagnosis treatment difficult. Warfarin often needed after valvular but may be dangerous if HIT ongoing. Danaparoid the only anticoagulant whose mechanism action has been demonstrated to counteract pathogenesis HIT. However, 24-hour half-life challenges its use surgery....
The aim of this study was to evaluate the effect polymorphisms affecting clopidogrel metabolism (CYP3A4 IVS10+12G/A and CYP2C19*2) P2Y12 receptor (P2Y12 T744C) on modulating platelet function in acute coronary syndrome patients dual antiplatelet treatment.Residual reactivity (RPR) phenomenon therapy requires clarification. T744C, CYP3A4 and, healthy individuals only, CYP2C19*2 have been investigated; however, influence a large population high-risk vascular treatment has not yet elucidated.A...
Summary A high platelet turnover rate produce a population of immature reticulated platelets (RP) that could confer, despite antiplatelet drugs, residual reactivity (RPR) in coronary artery disease (CAD) patients. To assess the influence RP on CAD patients dual therapy we measured 372 by using Sysmex XE-2100 haematology analyzer and function optical aggregometry (PA) platelet-rich-plasma induced 1 mmol arachidonic acid (AA-PA) 10 μM ADP (ADP-PA). RPR was defined as either AA-PA >20% or...
Numerous studies have demonstrated a relationship between adherence to Mediterranean diet and prevention of chronic degenerative diseases. The aim this study was validate novel instrument measure based on the literature (the MEDI-LITE score). Two-hundred-and-four clinically healthy subjects completed both score validated MedDietScore (MDS). Significant positive correlation MDS scores found in population (R = .70; p < .0001). Furthermore, statistically significant correlations were for all...
Abstract Aims Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is an increasingly recognized cause of heart failure. We sought to characterize the structural and functional echocardiographic phenotype across spectrum wild-type (wtATTR-CM) hereditary (hATTR-CM) transthyretin features predicting prognosis. Methods results studied 1240 patients with ATTR-CM who underwent prospective protocolized evaluations comprising full assessment survival between 2000 2019, 766 wtATTR-CM 474 hATTR-CM,...
Summary Reticulated platelets (RP) are newly-formed with a greater mass, residual amount of RNA and an increased prothrombotic potential. No studies investigating the association between RP risk cardiovascular death in acute coronary syndrome (ACS) patients available. In frame AMI-Florence 2 study, we investigated 229 (154 M/ 75 F) ACS (125 ST-elevation myocardial infarction [STEMI]; 104 Non-STEMI/Unstable Angina). were measured by using Sysmex XE-2100 haematology analyzer expressed as...
Abstract Introduction A hypercoagulable condition was described in patients with coronavirus disease 2019 (COVID-19) and proposed as a possible pathogenic mechanism contributing to progression lethality. Aim We evaluated if in-hospital administration of heparin improved survival large cohort Italian COVID-19 patients. Methods In retrospective observational study, 2,574 unselected hospitalized 30 clinical centers Italy from February 19, 2020 June 5, laboratory-confirmed severe acute...