María Paniagua‐García
A5026565028- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Acute Ischemic Stroke Management
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Infectious Diseases and Mycology
- Acute Myocardial Infarction Research
- Antibiotic Use and Resistance
- Hepatitis B Virus Studies
- Venous Thromboembolism Diagnosis and Management
- Actinomycetales infections and treatment
- Abdominal Trauma and Injuries
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 detection and testing
- Head and Neck Anomalies
- Nitric Oxide and Endothelin Effects
- Cardiac Structural Anomalies and Repair
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Rheumatoid Arthritis Research and Therapies
Instituto de Biomedicina de Sevilla
2017-2025
Hospital Universitario Virgen del Rocío
2020-2025
Universidad de Sevilla
2019-2025
Hospital Universitario Virgen Macarena
2019-2024
Centro de Investigación Biomédica en Red
2024
Instituto de Salud Carlos III
2024
Hospital Universitario 12 De Octubre
2001-2007
New York Medical College
1990-1992
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is deficit DC numbers and IFN-α production, which has been associated with disease severity. this work, we described that addition deficiency, several...
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
The renovascular effects of cytochrome P450-dependent arachidonic acid (P450-AA) metabolites synthesized by rat and rabbit kidneys were studied in the isolated kidney under conditions constant flow examined for their dependency on cyclooxygenase relative to expression vasoactivity. Kidneys perfused with Krebs-Henseleit solution, perfusion pressure was raised levels 90 110 mm Hg addition 2 3 microM phenylephrine perfusate. Close arterial injection 1 20 micrograms 5,6-, 8,9-...
Objetivo: O objetivo desta revisão bibliográfica foi compilar o conhecimento atual sobre definição, epidemiologia, fisiopatologia, fatores de risco, manifestações clínicas, complicações e tratamentos associados à doença do refluxo gastroesofágico (DRGE) em lactentes crianças. Metodologia: As buscas foram realizadas por meio pesquisas nas bases dados PubMed Central (PMC) Biblioteca Virtual Saúde (BVS). Foram utilizados três descritores principais combinados ao termo booleano "AND":...
Abstract The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in swabs. Quantitative Synthetic RNA cycle threshold values were used calculate log 10 copies/mL. Disease severity end follow up categorized into mild, moderate, and severe. Primary endpoint composite intensive care unit (ICU) admission...
We have reported that 5,6-epoxyeicosatrienoic acid (5,6-EET) was the only cytochrome P-450-dependent arachidonic (AA) epoxide to dilate isolated, perfused caudal artery of rat. investigated mechanisms by which 5,6-EET dilates rat-tail studying effect deendothelialization and inhibition AA metabolic pathways (cyclooxygenase, lipoxygenase, P-450 monooxygenase) on vascular action epoxide. Rat isolated arteries were with Krebs-Henseleit solution at 37 degrees C, pH 7.4, gassed 95% O2-5% CO2....
Abstract SARS‐CoV‐2 specific T‐cell response has been associated with disease severity, immune memory and heterologous to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality antibody levels in these three scenarios is needed. In present study, we found that, acute infection, while mild was high polyfunctionality biased IL‐2 production inversely correlated anti‐S IgG levels, combinations only including IFN‐γ absence perforin predominated...
Objectives Our objective was to identify patient factors associated with being untreated for hepatitis C virus ( HCV ) infection in HIV ‐coinfected patients. Methods A prospective longitudinal study carried out. ‐infected patients active chronic included the HERACLES cohort NCT 02511496) constituted population. The main outcome receipt of direct‐acting antiviral DAA treatment from 1 May 2015 2017. population divided into who were receiving during follow‐up and those not. Results Of 15 556...
The use of systemic corticosteroids in severely ill patients with coronavirus disease 2019 (COVID-19) is controversial. We aimed to evaluate the efficacy and safety corticosteroid pulses COVID-19 pneumonia. A quasi-experimental study, before after, was performed a tertiary referral hospital, including admitted showing COVID-19-associated standard treatment protocol included targeted antiviral therapy from 23rd March 2020, additionally methylprednisolone 30th 2020. primary outcome composite...
Carbapenem-resistant Enterobacterales (CRE) bloodstream infections (BSIs) are a major threat to patients. To date, data on risk factors have been limited, with low internal and external validity. In this multicentre study, for CRE BSI were determined by comparison two control groups: patients carbapenem-susceptible (CSE) BSI, without infection (uninfected patients).
We evaluated the efficacy of adoptive transfer memory B, CD4+, and CD8+ T lymphocytes compared with sulbactam tigecycline in an experimental murine pneumonia model by two multidrug-resistant Acinetobacter baumannii strains, colistin-susceptible AbCS01 colistin-resistant AbCR17. Pharmacodynamically optimized antimicrobial dosages were administered for 72 h, intravenous administration 2 × 106 each cells a single dose 30 min post-infection. Bacterial lung blood counts mortality rates analyzed....
Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort 488 SOTR, nonvaccinated (n = 394) and vaccinated 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, radiological variables to identify clinical A, B, C. median age was 61.0 (51–69) years, 330 (67.6%) 158 (32.4%) were men women,...
ABSTRACT SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality antibody levels in these three scenarios is needed. In present study we found that, acute infection, while mild was high polyfunctionality biased IL-2 production inversely correlated anti-S IgG levels, combinations only including IFN-γ absence perforin predominated...