A5067768730- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Click Chemistry and Applications
- Pneumonia and Respiratory Infections
- Animal Virus Infections Studies
- Synthesis and Biological Activity
- Long-Term Effects of COVID-19
- Marine Sponges and Natural Products
- Influenza Virus Research Studies
- Microbial Natural Products and Biosynthesis
- RNA Interference and Gene Delivery
- interferon and immune responses
- CRISPR and Genetic Engineering
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Immunology Research
Instituto de Biomedicina de Sevilla
2019-2024
Hospital Universitario Virgen del Rocío
2020-2024
Universidad de Sevilla
2019-2024
Centro de Investigación Biomédica en Red
2022
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is deficit DC numbers and IFN-α production, which has been associated with disease severity. this work, we described that addition deficiency, several...
Abstract The main objective was to evaluate the viability of SARS-CoV-2 viral particles excreted in stools. In addition, we aimed identify clinical factors associated with detection RNA feces, and determine if its presence is an unfavorable outcome, defined as intensive care unit (ICU) admission and/or death. A prospective multicenter cohort study COVID-19 adult patients, confirmed infection by RT-PCR assay nasopharyngeal (NP) swabs admitted four hospitals Spain, from March 2020 February...
Abstract The repositioning of drugs already approved by regulatory agencies for other indications is an emerging alternative the development new antimicrobial therapies. process involves lower risks and costs than de novo novel drugs. Currently, infections adenovirus show a steady increment with high clinical impact in immunosuppressed immunocompetent patients. lack safe efficacious drug to treat these supports search antiviral Here we evaluated anti-adenovirus activity niclosanide,...
Abstract The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in swabs. Quantitative Synthetic RNA cycle threshold values were used calculate log 10 copies/mL. Disease severity end follow up categorized into mild, moderate, and severe. Primary endpoint composite intensive care unit (ICU) admission...
The effective treatment of adenovirus (HAdV) infections in immunocompromised patients still poses great challenges. Herein, we reported our continued efforts to optimize a series salicylamide derivatives as potent inhibitors HAdV infection. Of these, nine compounds (11, 13, 14, 17, 20, 58, 60, 62, and 70) showed significantly improved anti-HAdV activities with nanomolar submicromolar IC50 values high selectivity indexes (SI > 100), indicating better safety windows, compared those the lead...
Human adenovirus (HAdV) and cytomegalovirus (HCMV) are cause of high morbidity mortality in patients receiving solid organ (SOT) hematopoietic stem cell transplantations (HSCT). Immunosuppressors universally used to prevent graft-versus-host disease (GVHD) HSCT graft rejection SOT. The long-term use these drugs is associated with a risk infections, but there also evidences their specific interference virus infection. antiviral activity immunosuppressors commonly the clinical practice SOT...
Viral infections are one of the main human health problems in recent decades and cancer remains most lethal diseases worldwide. The development new antiviral drugs for treatment adenovirus (HAdV) continues to be a challenging goal medicinal chemistry. There is no specific drug approved treat caused by HAdV so far off-label treatments currently available show great variability their effectiveness. In relation cancer, designed act on targets altering activity involved transporters genes....
An effective therapy for human adenovirus (HAdV) infections in immunocompromised patients and healthy individuals with community-acquired pneumonia remains an unmet medical need. We herein reported a series of novel substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogues as potent HAdV inhibitors. Compounds 6, 15, 29, 40, 43, 46, 47, 54 exhibited increased selectivity indexes (SI > 100) compared to the lead compound niclosamide, while maintaining sub-micromolar low...
Over the years, human adenovirus (HAdV) has progressively been recognized as a significant viral pathogen. Traditionally associated with self-limited respiratory, gastrointestinal, and conjunctival infections, mainly in immunocompromised patients, HAdV is currently considered to be pathogen presenting morbidity mortality both immunosuppressed otherwise healthy individuals. Currently available therapeutic options are limited because of their lack effectivity related side effects. In this...
Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array symptoms from mild respiratory illnesses to disseminated life-threatening infections in immunocompromised individuals. However, no antiviral drug has been approved specifically for the treatment HAdV infections. Herein, we report our continued efforts optimize salicylamide derivatives discover compound 16 (JMX0493) as potent inhibitor infection. Compound displays submicromolar IC50 values, higher...
Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially paediatric and immunosuppressed patients. Here, we describe design, synthesis biological evaluation as anti-adenovirus agents new library (57 compounds) diester, monoester triazole derivatives based on 3-amino-1,2-propanediol skeleton. Seven compounds (17, 20, 26, 34, 44, 60 66) were selected their high anti-HAdV activity at low micromolar...
The objectives of this work were to assess the diagnostic sensitivity and specificity nasopharyngeal (NP) swabs for viral community-acquired pneumonia (CAP) performance severity index (PSI) CURB-65 scores in CAP adults. A prospective observational cohort study consecutive 341 hospitalized adults with was performed between January 2018 March 2020. Demographics, comorbidities, symptoms/signs, analytical data, scores, antimicrobials, outcomes recorded. Blood, NP swabs, sputum, urine samples...