Sonsoles Salto‐Alejandre
A5045118610- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Respiratory viral infections research
- Machine Learning in Healthcare
- Renal Transplantation Outcomes and Treatments
- COVID-19 diagnosis using AI
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Impact on Reproduction
- Infectious Aortic and Vascular Conditions
- Antibiotic Use and Resistance
- Hematopoietic Stem Cell Transplantation
- Animal Virus Infections Studies
- Cardiac Valve Diseases and Treatments
- Pneumonia and Respiratory Infections
- Patient Satisfaction in Healthcare
- Infective Endocarditis Diagnosis and Management
- Pancreatitis Pathology and Treatment
Instituto de Biomedicina de Sevilla
2020-2024
Universidad de Sevilla
2020-2024
Hospital Universitario Virgen del Rocío
2020-2024
Instituto de Salud Carlos III
2022-2024
Johns Hopkins University
2022-2024
Centro de Investigación Biomédica en Red
2022-2024
May Institute
2022
Skåne University Hospital
2021
Lund University
2021
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is deficit DC numbers and IFN-α production, which has been associated with disease severity. this work, we described that addition deficiency, several...
During the COVID-19 pandemic, implementation of antimicrobial stewardship strategies has been recommended. This study aimed to assess impact pandemic in a tertiary care Spanish hospital with an active ongoing programme (ASP). For 20-week period, we weekly assessed consumption, incidence density, and crude death rate per 1000 occupied bed days candidemia multidrug-resistant (MDR) bacterial bloodstream infections (BSI). We conducted segmented regression analysis time series. Antimicrobial...
Abstract The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in swabs. Quantitative Synthetic RNA cycle threshold values were used calculate log 10 copies/mL. Disease severity end follow up categorized into mild, moderate, and severe. Primary endpoint composite intensive care unit (ICU) admission...
The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study 210 consecutive SOTRs hospitalized COVID-19 12 Spanish centers from 21 February 6 May 2020. Data pertaining demographics, chronic underlying diseases, transplantation features, clinical, therapeutics, complications were collected. primary endpoint composite intensive care unit (ICU) admission and/or...
Background Infective endocarditis is associated with higher mortality in elderly patients, but the role of surgery this group has not been fully evaluated. The aim study was to assess outcomes left-sided infective patients and determine influence on elderly. Methods Results A nationwide retrospective performed 2186 recorded SRIE (Swedish Registry Endocarditis), divided into aged <65 years (n=864), 65 79 (n=806), ≥80 (n=516). Survival analysis using Swedish National Population Registry,...
Isavuconazole has theoretical advantages over other mold-active triazoles for the treatment of invasive aspergillosis and mucormycosis after solid organ transplantation (SOT). The available clinical experience, nevertheless, is scarce.We performed a retrospective study including all adult SOT recipients with proven or probable mold disease (IMD) that received isavuconazole ≥24 h as first-line salvage therapy at 10 Spanish centers between September 2017 November 2021. primary efficacy outcome...
Interferon-β is an attractive drug for repurposing and use in the treatment of COVID-19, based on its vitro antiviral activity encouraging results from clinical trials. The aim this study was to analyze impact early interferon-β patients admitted with COVID-19 during first wave pandemic.This post hoc analysis a COVID-19@Spain multicenter cohort included 3808 consecutive adult hospitalized 1 January 17 March 2020. primary endpoint 30-day all-cause mortality, main exposure interest...
Isavuconazole (ISA) and voriconazole (VORI) are recommended as the first-line treatment for invasive aspergillosis (IA). Despite theoretical advantages of ISA, both triazole agents have not been compared in solid organ transplant recipients.
ABSTRACT Background Outcomes after bebtelovimab treatment for COVID‐19 were favorable most but not all solid organ transplant recipients (SOTRs) during the era of Omicron BA.2 to BA.5, effects timing administration on these outcomes are unknown. We sought compare SOTR who received early (“EBT”, given ≤ 2 days from diagnosis) versus late (“LBT”, between Days 3 and 7), no (NBT). Methods This was a retrospective cohort study SOTRs with mild‐to‐moderate COVID‐19, endpoint 30‐day COVID‐19‐related...
Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort 488 SOTR, nonvaccinated (n = 394) and vaccinated 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, radiological variables to identify clinical A, B, C. median age was 61.0 (51–69) years, 330 (67.6%) 158 (32.4%) were men women,...