George L. Daikos
A5038285556- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Urinary Tract Infections Management
- Antimicrobial Resistance in Staphylococcus
- Vibrio bacteria research studies
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Microscopic Colitis
- Bacterial Infections and Vaccines
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Escherichia coli research studies
- Sepsis Diagnosis and Treatment
- Bacterial biofilms and quorum sensing
- Tuberculosis Research and Epidemiology
- HIV-related health complications and treatments
- Pharmaceutical and Antibiotic Environmental Impacts
National and Kapodistrian University of Athens
2016-2025
Laiko General Hospital of Athens
2016-2025
Mitera Hospital
2024
Athens State University
2005-2020
Hospital Universitario Virgen Macarena
2017
Instituto de Biomedicina de Sevilla
2017
Universidad de Sevilla
2017
Oxford University Hospitals NHS Trust
2016
Centers for Disease Control and Prevention
2013
University General Hospital Attikon
2006
Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed estimate the burden of infections caused by public concern in countries EU European Economic Area (EEA) 2015, measured number cases, deaths, disability-adjusted life-years (DALYs).We estimated incidence with 16 antibiotic resistance-bacterium combinations from Antimicrobial Resistance Surveillance Network...
The polymyxin antibiotics colistin (polymyxin E) and B became available in the 1950s thus did not undergo contemporary drug development procedures. Their clinical use has recently resurged, assuming an important role as salvage therapy for otherwise untreatable gram-negative infections. Since their reintroduction into clinic, significant confusion remains due to existence of several different conventions used describe doses polymyxins, differences formulations, outdated product information,...
ABSTRACT Carbapenemase-producing Klebsiella pneumoniae strains (CP-Kps) are currently among the most important nosocomial pathogens. An observational study was conducted during 2009 to 2010 in two hospitals located a high-prevalence area (Athens, Greece). The aims were (i) evaluate clinical outcome of patients with CP-Kp bloodstream infections (BSIs), (ii) identify predictors mortality, and (iii) various antibiotic schemes employed. A total 205 BSIs identified: 163 (79.5%) infected KPC or...
Treatment options for carbapenem-resistant Enterobacteriaceae (CRE) infections are limited and CRE remain associated with high clinical failure mortality rates, particularly in vulnerable patient populations. A Phase 3, multinational, open-label, randomized controlled trial (TANGO II) was conducted from 2014 to 2017 evaluate the efficacy/safety of meropenem-vaborbactam monotherapy versus best available therapy (BAT) CRE.A total 77 patients confirmed/suspected infection (bacteremia,...
In vitro data support the use of combination aztreonam (ATM) with ceftazidime-avibactam (CAZ-AVI), but clinical studies are lacking. The aim our study was to compare outcome patients bloodstream infections (BSIs) due metallo-β-lactamase (MBL)-producing Enterobacterales treated either CAZ-AVI plus ATM or other active antibiotics (OAAs).This a prospective observational including admitted 3 hospitals in Italy and Greece. primary measure 30-day all-cause mortality. Secondary outcomes were...
BackgroundPneumonia and bloodstream infections (BSI) due to extensively drug-resistant (XDR) Acinetobacter baumannii, XDR Pseudomonas aeruginosa, carbapenem-resistant Enterobacterales (CRE) are associated with high mortality rates, therapeutic options remain limited. This trial assessed whether combination therapy colistin meropenem was superior monotherapy for the treatment of these infections.MethodsThe OVERCOME (Colistin Monotherapy versus Combination Therapy) an international,...
<h2>Abstract</h2><h3>Objectives</h3> To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and investigate effect of clinical management on differences in observed outcomes a multinational matched cohort study. <h3>Methods</h3> A prospective matched-cohorts study (NCT02709408) was performed 50 European hospitals from March 2016 November 2018. The main outcome 30-day with an active post-discharge follow-up when applied. CRE included patients...
Acquisition of multiple carbapenemase genes by Klebsiella pneumoniae (Kp) is an emerging public health threat. Here, we aim to elucidate the population structure Kp blood isolates carrying two different and identify mechanism facilitating their dissemination. The study was conducted in a tertiary healthcare center between 2014 2022. Twenty-four patients with bacteremia caused were identified. All 24 analyzed short-read genome sequences supplemented long reads selected number isolates....
VIM-1-producing Klebsiella pneumoniae (VPKP) is an emerging pathogen. A prospective observational study was conducted to evaluate the importance of VIM production on outcome patients with K. bloodstream infections (BSIs). Consecutive BSIs were identified and followed up until patient discharge or death. total 162 included in analysis; 67 (41.4%) infected VPKP, 95 non-VPKP. Fourteen VPKP carbapenem resistant (Carb(r)) (MIC > 4 mug/ml), whereas none non-VPKP exhibited resistance. The a Carb(r)...
Adaptive resistance to the bactericidal effect of an aminoglycoside antibiotic was induced in Pseudomonas aeruginosa and other aerobic gram-negative bacilli by initial exposure drug. Both subinhibitory inhibitory concentrations produced bacterial cells surviving effects ionic binding. Development drug refractoriness required adaptive period growth, enhanced continued presence drug, reversed after several hours growth drug-free medium. Unstable not explained selection mutants. The mechanism...
Non-polio human enteroviruses are the leading cause of aseptic meningitis in children. The role enterovirus PCR for diagnosis and management has not been fully explored.A retrospective study was conducted to determine epidemiological, clinical, laboratory characteristics evaluate this clinical entity. medical records children who had as discharge or viral were reviewed. A total 506 children, median age 5 years, identified. annual incidence rate estimated be 17/100,000 less than 14 years age....