A5025663292- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Smoking Behavior and Cessation
- Global Cancer Incidence and Screening
- Gastric Cancer Management and Outcomes
- Global Health Care Issues
- Global Public Health Policies and Epidemiology
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Antibiotic Use and Resistance
- Health disparities and outcomes
- Colorectal and Anal Carcinomas
- COVID-19 epidemiological studies
- Multiple and Secondary Primary Cancers
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Cancer Genomics and Diagnostics
- Workplace Health and Well-being
- Colorectal Cancer Treatments and Studies
- Global Maternal and Child Health
- Health, Environment, Cognitive Aging
- Pharmaceutical Economics and Policy
- Cancer, Lipids, and Metabolism
- Antibiotic Resistance in Bacteria
- Primary Care and Health Outcomes
The University of Melbourne
2013-2024
Melbourne Health
2022-2023
The University of Queensland
2022
National Health and Medical Research Council
2022
Organisation de Coopération et de Développement Economiques
2018-2020
Seoul National University
2014
Université Claude Bernard Lyon 1
2014
The Royal Melbourne Hospital
2011
Peter MacCallum Cancer Centre
2011
Cancer Council Victoria
2011
Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed estimate the burden of infections caused by public concern in countries EU European Economic Area (EEA) 2015, measured number cases, deaths, disability-adjusted life-years (DALYs).We estimated incidence with 16 antibiotic resistance-bacterium combinations from Antimicrobial Resistance Surveillance Network...
To examine changes in colorectal cancer mortality 34 European countries between 1970 and 2011.Retrospective trend analysis.World Health Organization database.Deaths from 2011. Profound screening treatment efficiency took place after 1988; therefore, particular attention was paid to the evolution of subsequent period.Time trends rates mortality, using joinpoint regression analysis. Rates were age adjusted standard population.From 1989 2011, increased by a median 6.0% for men decreased 14.7%...
Inheritance of a germline mutation in one the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes high risk colorectal other cancers (Lynch Syndrome). Use aspirin has been shown to be associated with reduced cancer for general population as well MMR gene carriers. The aim this study was determine whether use ibuprofen nontrial setting is We included 1858 participants Colon Cancer Family Registry who had found have pathogenic (carriers). used weighted Cox proportional hazards...
To identify COVID-19 quarantine system failures in Australia and New Zealand.
The Aotearoa/New Zealand Government is aiming to end the tobacco epidemic and markedly reduce Māori:non-Māori health inequalities by legislating: (1) denicotinisation of retail tobacco, (2) 95% reduction in outlets (c) a free-generation whereby people born after 2005 are unable legally purchase tobacco. This paper estimates future smoking prevalence, mortality inequality health-adjusted life year (HALY) impacts these strategies.
IMPORTANCE Apart from hysterectomy, there is no consensus recommendation for reducing endometrial cancer risk women with a mismatch repair gene mutation (Lynch syndrome).OBJECTIVE To investigate the association between hormonal factors and in Lynch syndrome. DESIGN, SETTING, AND PARTICIPANTSA retrospective cohort study included 1128 identified Colon Cancer Family Registry.Data were analyzed weighted approach.Participants recruited 1997 2012 centers across United States, Australia, Canada,...
Tumor testing of colorectal cancers (CRC) for mismatch repair (MMR) deficiency is an effective approach to identify carriers germline MMR gene mutation (Lynch syndrome). The aim this study was in two cohorts population-based CRC utilizing a combination tumor and approaches.
Abstract Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings relationship between alcohol consumption and risk been inconclusive. Methods: 1,925 MMR gene mutations carriers recruited into Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models used to estimate ratios (HR) 95%...
Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous CRC. We examined the associations between personal, tumour-related and lifestyle factors, A total 7,863 participants incident colon or rectal who were recruited in USA, Canada Australia to Colon Cancer Family Registry during 1997-2012, except those identified as high-risk, for example, Lynch syndrome, followed up approximately every 5 years. estimated CRC, defined first new primary CRC following an...
People with a DNA mismatch repair (MMR) gene mutation have substantially elevated risk of colorectal cancer (CRC) but the modifiers this are not well established. We investigated association between dietary supplement intake and CRC for carriers.This study included 1966 (56% female) carriers an MMR (719 MLH1, 931 MSH2, 211 MSH6 105 PMS2) who were recruited from USA, Canada, Australia New Zealand into Colon Cancer Family Registry 1997 2012. Information on lifestyle factors including was...
<h3>Importance</h3> Countries have varied enormously in how they responded to the COVID-19 pandemic, ranging from elimination strategies (eg, Australia, New Zealand, Taiwan) tight suppression (not aiming for but rather keep infection rates low [eg, South Korea]) loose Europe, United States) virtually unmitigated Brazil, India). Weighing best option, based on health and economic consequences due lockdowns, is necessary. <h3>Objective</h3> To determine optimal policy response, using a net...
With 14.234 diagnoses and over 4047 deaths reported in 2007, colorectal cancer (CRC) is the second most common cause of cancer-related mortality Australia. The direct treatment cost has recently been estimated to be around AU$1.2 billion for year 2011, which corresponds a four-fold increase, compared 2001. Excluding CRCs due known rare genetic disorders, 20% 25% all occur familial aggregation setting variants or shared environmental risk factors that are yet characterised. A targeted...
BackgroundAntimicrobial resistance is widely considered an urgent global health issue due to associated mortality and disability, societal healthcare costs.AimTo estimate the past, current projected future proportion of infections resistant treatment for eight priority antibiotic-bacterium combinations from 2000 2030 52 countries.MethodsWe collated data a variety sources including ResistanceMap World Bank. Feature selection algorithms multiple imputation were used produce complete historical...
Abstract Objectives To identify COVID-19 outbreaks and border control failures associated with quarantine systems in Australia New Zealand to estimate the failure risks. Design, setting, participants Observational epidemiological study of travellers transiting up 15 June 2021. Main outcome measures The incidence related arising from quarantine, risk for those estimated both per 100,000 1000 SARS-CoV-2 positive cases. Results had 32 2021 (22 10, respectively). One resultant outbreak involved...
A risk-stratified approach to colorectal cancer (CRC) screening could result in a more acceptable balance of benefits and harms, be cost-effective.To determine the effect consultation general practice using computerised risk assessment decision support tool (Colorectal RISk Prediction, CRISP) on risk-appropriate CRC screening.Randomised controlled trial 10 practices Melbourne, Australia, from May 2017 2018.Participants were recruited consecutive sample patients aged 50-74 years attending...
Our objective was to determine screening practices of unaffected people in the general population at moderately increased and potentially high risk colorectal cancer (CRC) because their family history disease. A total 1,627 participants Australasian Colorectal Cancer Family Registry study were classified into two CRC categories, according strength We calculated proportion that adhered national guidelines by age group for each familial category. carried out a multinomial logistic regression...