A5003493669- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Colorectal Cancer Treatments and Studies
- Global Cancer Incidence and Screening
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Occupational Health and Safety Research
- Traffic and Road Safety
- Cancer Risks and Factors
- Genomics and Rare Diseases
- Risk and Safety Analysis
- Multiple and Secondary Primary Cancers
- Family Support in Illness
- Breast Cancer Treatment Studies
- Ethics in Clinical Research
- Chronic Disease Management Strategies
- Food Security and Health in Diverse Populations
- Patient-Provider Communication in Healthcare
- Health and Wellbeing Research
- Breast Lesions and Carcinomas
- COVID-19 Clinical Research Studies
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Pancreatic and Hepatic Oncology Research
Colorado School of Public Health
2011-2024
University of Colorado Anschutz Medical Campus
2011-2024
University of Colorado Denver
2012-2024
University of Colorado Cancer Center
2000-2024
American Indian Center
2020
University of Southern California
2018
Cedars-Sinai Medical Center
2018
John Wiley & Sons (United States)
2016
University of Colorado Boulder
2011-2015
Cancer Research Center
2014
Precision medicine initiatives across the globe have led to a revolution of repositories linking large-scale genomic data with electronic health records, enabling analyses entire phenome. Many these focus solely on research insights, leading limited direct benefit patients. We describe biobank at Colorado Center for Personalized Medicine (CCPM Biobank) that was jointly developed by University Anschutz Medical Campus and UCHealth serve as unique, dual-purpose clinical resource accelerating...
Purpose The rate of adherence to regular colonoscopy screening in individuals at increased familial risk colorectal cancer (CRC) is suboptimal, especially among rural and other geographically underserved populations. Remote interventions may overcome geographic system-level barriers. We compared the efficacy a telehealth-based personalized assessment communication intervention with mailed educational brochure for improving at-risk relatives patients CRC. Methods Eligible age 30 74 years who...
Background Construction of Denver International Airport (DIA) provided a unique opportunity to describe the magnitude injury on major construction project for which complete data and hours at risk were available over 32,000 employees working 31 million hours. Methods Comprehensive payroll all workers, who paid standard Davis-Bacon wages, allowed calculation person-hours by job classification. Complete reporting, facilitated single workers' compensation plan covering contracts an on-site...
Relatives of colorectal cancer (CRC) patients are at increased risk for the disease, yet screening rates still remain low. Guided by Extended Parallel Process Model, we examined impact a personalized, remote communication intervention on behavioral intention and colonoscopy uptake in relatives CRC patients, assessing original additive model an alternative which each theoretical construct contributes uniquely.We collected intention-to-screen medical record-verified information 218 individuals...
Abstract Background: Individuals with a strong family history of colorectal cancer have significant risk for cancer, although adherence to colonoscopy screening in these groups remains low. This study assessed whether tailored telephone counseling intervention can increase members high-risk families randomized, controlled trial. Methods: Eligible participants were recruited from two national registries if they had first-degree relative under age 60 or multiple affected members, which...
Hispanic women are at a lower risk of getting breast cancer than non-Hispanic white (NHW) women, yet they experience higher mortality after diagnosis. There is some evidence to suggest differences in tumor pathology; however, very limited research has been published on women. This represents one the first studies evaluate prevalence markers and phenotypic subtypes that associated with poorer prognosis (human epidermal growth factor receptor 2 [HER2], triple negative basal-like tumors) among...
Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous CRC. We examined the associations between personal, tumour-related and lifestyle factors, A total 7,863 participants incident colon or rectal who were recruited in USA, Canada Australia to Colon Cancer Family Registry during 1997-2012, except those identified as high-risk, for example, Lynch syndrome, followed up approximately every 5 years. estimated CRC, defined first new primary CRC following an...
Systematic screening of all colorectal tumors for Lynch Syndrome (LS) has been recommended since 2009. Currently, implementation LS in healthcare systems remains variable, likely because involves the complex coordination multiple departments and individuals across system. Our specific aims are to (1) describe variation systems; (2) identify conditions associated with both practice optimal implementation; (3) determine relative effectiveness, efficiency, costs different protocols by system;...
Abstract This study was an investigation of awareness, cognitions, and psychosocial educational needs related to genetic counseling testing among Latinas non‐Latina whites at increased risk for having a BRCA1/2 mutation. Sixty‐three Latina eighty‐four white women completed telephone surveys employing mixture quantitative qualitative questions assessing benefits, risks, barriers, communication preferences regarding testing. Among participants who had not previously counseling/testing, 56.9%...
Knowledge of family cancer history is important for assessing risk and guiding screening recommendations.To quantify how often throughout adulthood clinically significant changes occur in that would result recommendations earlier or intense screening.Descriptive study examining baseline follow-up data from participants the Cancer Genetics Network (CGN), a US national population-based registry, between 1999 2009.Adults with personal history, both enrolled CGN through registries. Retrospective...
Background The Denver International Airport construction project provided a rare opportunity to identify risk factors for injury on large which 769 contractors were hired complete 2,843 contracts. Workers' compensation claims and payroll data individual contracts recorded in an administrative database developed by the project's Owner-Controlled Insurance Program. Methods From linked with employee demographic information, we calculated rates per 200,000 person-hours contract over...
We tested the efficacy of a remote tailored intervention Tele-Cancer Risk Assessment and Evaluation (TeleCARE) compared with mailed educational brochure for improving colonoscopy uptake among at-risk relatives colorectal cancer patients examined subgroup differences based on participant reported cost barriers.
OBJECTIVES: Individuals whose families meet the Amsterdam II clinical criteria for hereditary non-polyposis colorectal cancer are recommended to be referred genetic counseling and have colonoscopic screening every 1–2 years. To assess uptake knowledge of guideline-based in unaffected members who their treating endoscopists. METHODS: Participants Family Health Promotion Project met were surveyed regarding risk-appropriate guidelines colonoscopy screening. Endoscopy/pathology reports obtained...
Abstract Present investigations suggest that ∼30% of colorectal cancer cases arise on the basis inherited factors. We hypothesize majority factors are moderately penetrant genes, common in population. use an affected sibling pair approach to identify genetic regions coinherited by siblings with cancer. Individuals from families at least two diagnosed adenocarcinoma or high-grade dysplasia were enrolled. Known familial syndromes excluded. A genome-wide scan 151 DNA samples 70 kindreds was...
Background To lay groundwork for identifying patterns of injury etiology, we sought to describe experience associated with types work performed at construction sites by examining workers' compensation (WC) claims the 32,081 workers who built Denver International Airport (DIA). Methods Injury rates and WC payment were calculated 25 based on payroll data reported DIA's owner-controlled insurance program according National Council Compensation Insurance job classifications. By linking DIA...