A5111755060- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Lung Cancer Research Studies
- DNA Repair Mechanisms
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Folate and B Vitamins Research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- Bacterial Identification and Susceptibility Testing
- Lung Cancer Treatments and Mutations
- Carcinogens and Genotoxicity Assessment
- Ethics in Clinical Research
- Prenatal Screening and Diagnostics
- Microscopic Colitis
- Skin Protection and Aging
- Chemical Reactions and Isotopes
- Clostridium difficile and Clostridium perfringens research
- Myasthenia Gravis and Thymoma
- T-cell and B-cell Immunology
- Multiple and Secondary Primary Cancers
- Economic and Financial Impacts of Cancer
- Gastrointestinal motility and disorders
- Plant Genetic and Mutation Studies
University of New Mexico
2013-2024
New Mexico Cancer Center
2013-2017
UNM Comprehensive Cancer Center
2013-2017
University of Utah
2014-2016
Rutgers, The State University of New Jersey
2014-2016
Georgetown University
2014-2016
University of North Carolina at Chapel Hill
2016
Huntsman Cancer Institute
2014
Georgetown University Medical Center
2014
University of Minnesota
2012
The perivascular space (PVS) of human thymus increases in volume during aging as thymopoiesis declines. Understanding the composition PVS is therefore vital to understanding mechanisms thymic atrophy. We have analyzed 87 normal and 31 myasthenia gravis (MG) tissues from patients ranging age newborn 78 years, using immunohistologic molecular assays. confirmed that although epithelial (TES) decreases progressively with age, active T-cell receptor gene rearrangement continued normally within...
BackgroundThe growing demand for cancer genetic services underscores the need to consider approaches that enhance access and efficiency of counseling. Telephone delivery may improve these individuals experiencing geographic (rural areas) structural (travel time, transportation, childcare) barriers access.
Purpose The ongoing integration of cancer genomic testing into routine clinical care has led to increased demand for genetic services. To meet this demand, there is an urgent need enhance the accessibility and reach such services, while ensuring comparable delivery outcomes. This randomized trial compared 1-year outcomes telephone counseling with in-person among women at risk hereditary breast and/or ovarian living in geographically diverse areas. Patients Methods Using population-based...
Understanding the epidemiology of carbapenem-resistant A. baumannii complex (CRAB) and patients impacted is an important step toward informing better infection prevention control practices improving public health response.
One promising approach for early detection of lung cancer is by monitoring gene promoter hypermethylation events in sputum. Epidemiologic studies suggest that dietary fruits and vegetables the micronutrients they contain may reduce risk cancer. In this study, we evaluated whether diet multivitamin use influenced prevalence methylation cells exfoliated from aerodigestive tract current former smokers. Members (N = 1,101) Lovelace Smokers Cohort completed Harvard Food Frequency Questionnaire...
Abstract Many people frequently tan indoors despite being aware of the increased risk melanoma. Ultraviolet radiation is hypothesized to modify biological reward pathways, for example, through dopamine neurotransmitter system, reinforce tanning behaviour. In this pilot study, we relied on questionnaire and DNA data from a recently completed case–control study examine 67 single‐nucleotide polymorphisms ( SNP s) related haplotypes in five receptor drug metabolism genes relation indoor among...
To address the association between sequence variants within MGMT (O(6)-methylguanine-DNA methyltransferase) promoter-enhancer region and methylation of in premalignant lesions from smokers lung adenocarcinomas, their biological effects on gene regulation, targeting for therapy.Single nucleotide polymorphisms (SNP) identified through sequencing a 1.9 kb fragment 5' were examined relation to 169 adenocarcinomas 1,731 sputum samples smokers. The effect promoter haplotypes expression was tested...
Abstract Objective The incidence of infections from extended-spectrum β-lactamase (ESBL)–producing Enterobacterales (ESBL-E) is increasing in the United States. We describe epidemiology ESBL-E at 5 Emerging Infections Program (EIP) sites. Methods During October–December 2017, we piloted active laboratory- and population-based (New York, New Mexico, Tennessee) or sentinel (Colorado, Georgia) surveillance. An incident case was first isolation normally sterile body sites urine Escherichia coli...
Because interventions are available to prevent further recurrence in patients with recurrent Clostridioides difficile infection (rCDI), we identified predictors of multiple rCDI (mrCDI) adults at the time presentation initial CDI (iCDI). iCDI was defined as a positive C test any clinical setting during January 2018-August 2019 person aged ≥18 years no known prior test. ≥14 days from previous within 180 after iCDI; mrCDI ≥2 rCDI. We performed multivariable logistic regression analysis. Of 18...
Heinloth, A. N., Shackelford, R. E., Innes, C. L., Bennett, Li, Amin, P., Sieber, S. O., Flores, K. G., Bushel, P. and Paules, ATM-Dependent -Independent Gene Expression Changes in Response to Oxidative Stress, Gamma Irradiation, UV Irradiation. Radiat. Res. 160, 273–290 (2003).Ataxia telangiectasia (AT) is an autosomal recessive disorder characterized by progressive cerebellar degeneration, immunodeficiencies, telangiectasias, sensitivity ionizing radiation, high predisposition for...
Abstract The human genome is exposed to many different kinds of DNA‐damaging agents. While most damage detected and repaired through complex recognition repair machineries, some has the potential escape these mechanisms. Unrepaired DNA can give rise alterations mutations in an individual cell, which result malignant transformation, especially when critical genes are deregulated. In this study, we investigated gene expression changes response oxidative stress, gamma (γ) radiation, ultraviolet...
We tested the efficacy of a remote tailored intervention Tele-Cancer Risk Assessment and Evaluation (TeleCARE) compared with mailed educational brochure for improving colonoscopy uptake among at-risk relatives colorectal cancer patients examined subgroup differences based on participant reported cost barriers.
Background: This study evaluates predictors of BRCA1/2 testing among breast and ovarian cancer survivors who received genetic counseling as part a randomized trial moderators mode on uptake.Methods: Predictors within one year postcounseling were evaluated using multivariable logistic regression in population-based sample at increased hereditary risk randomly assigned to in-person (IPC; n = 379) versus telephone (TC; 402). Variables that moderated the association between identified by...
Gene promoter methylation detected in sputum predicts lung cancer risk smokers. Compared with non-Hispanic whites (NHW), Hispanics have a lower age-standardized incidence for cancer.This study compared the prevalence of NHWs using Lovelace Smokers cohort (n = 1998) and evaluated effect Native American ancestry (NAA) diet on biomarkers risk.Genetic was estimated 48 markers. Diet assessed by Harvard University Dietary Assessment questionnaire. Methylation 12 genes measured methylation-specific...
<b><i>Background/Aims:</i></b> This study explored the interest in genomic testing for modest changes colorectal cancer risk and preferences receiving communications among individuals with intermediate disease due to a family history of cancer. <b><i>Methods:</i></b> Surveys were conducted on 272 men women at enrolled randomized trial comparing remote personalized communication intervention (TeleCARE) aimed promoting colonoscopy generic print...
Scientific advances have allowed the development of multiplex gene-panels to assess many genes simultaneously in women who tested negative for BRCA1/2. We examined correlates interest testing that confer modest and moderate breast cancer risk communication preferences from BRCA families. Female first-degree relatives patients BRCA1/2 mutations (N = 149) completed a survey assessing genetic preferences. Interest was high (70 %) even higher if results could guide risk-reducing behavior changes...
Abstract The heritable disorder ataxia telangiectasia (AT) is caused by mutations in the AT-mutated (ATM) gene with manifestations that include predisposition to lymphoproliferative cancers and hypersensitivity ionizing radiation (IR). We investigated expression changes response IR human lymphoblasts fibroblasts from seven normal AT-affected individuals. Both cell types displayed ATM-dependent after IR, some responses shared varying type dose. Interestingly, 5 Gy ATM-independent not seen at...
Gene promoter hypermethylation is now regarded as a promising biomarker for the risk and progression of lung cancer.The one-carbon metabolism pathway postulated to affect deoxyribonucleic acid (DNA) methylation because it responsible generation S-adenosylmethionine (SAM), methyl donor cellular reactions.This study investigated association single nucleotide polymorphisms (SNPs) in six metabolism-related genes with sputum DNA from non-Hispanic white smokers Lovelace Smokers Cohort (LSC) (n =...
Abstract Among persons with an initial Clostridioides difficile infection (CDI) across 10 US sites in 2018 compared 2013, 18.3% versus 21.1% had ≥1 recurrent CDI (rCDI) within 180 days. We observed a 16% lower adjusted risk of rCDI 2013 (P &lt; .0001).
We investigated hospitalized carbapenem-resistant Enterobacterales (CRE) and extended-spectrum β-lactamase-producing (ESBL-E) cases with without COVID-19, as identified through Emerging Infections Program surveillance in 10 sites from 2020 to 2022. defined a CRE case the first isolation of Escherichia coli, Enterobacter cloacae complex, Klebsiella aerogenes, K oxytoca, pneumoniae, or variicola resistant any carbapenem. an ESBL-E E oxytoca third-generation cephalosporin nonresistant all...
Abstract Mutations in the human BRCA2 breast cancer susceptibility gene are associated with increased risks of breast, ovarian, and other cancers. has been hypothesized to function processes DNA damage/breakage repair, cell proliferation, apoptosis. These continually occur thymus during thymocyte development, mRNA is highly expressed relative most organs. We therefore used as a model system study expression function. Quantitative reverse transcription polymerase chain reaction experiments...