A5029731654- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Acne and Rosacea Treatments and Effects
- Antibiotic Use and Resistance
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Cytomegalovirus and herpesvirus research
- Nosocomial Infections in ICU
- COVID-19 epidemiological studies
- Listeria monocytogenes in Food Safety
- SARS-CoV-2 detection and testing
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- Immunodeficiency and Autoimmune Disorders
- Immune responses and vaccinations
- Urinary Tract Infections Management
- Quinazolinone synthesis and applications
- Enterobacteriaceae and Cronobacter Research
- Syphilis Diagnosis and Treatment
- Ocular Infections and Treatments
CDC Foundation
2019-2025
National Center for Emerging and Zoonotic Infectious Diseases
2022-2024
Centers for Disease Control and Prevention
2018-2024
Centers for Disease Control and Prevention
2024
Epidemic Intelligence Service
2018-2022
National Center for Immunization and Respiratory Diseases
2019-2020
Center for Surveillance, Epidemiology, and Laboratory Services
2018
University of California, Berkeley
2012-2015
University of California, San Diego
2011
To address high COVID-19 burden in U.S. nursing homes, rapid SARS-CoV-2 antigen tests have been widely distributed those facilities. However, performance data are lacking, especially asymptomatic people.
Abstract Background Carbapenemase-producing, carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) are extensively drug-resistant bacteria. We investigated the source of a multistate CP-CRPA outbreak. Methods Cases were defined as US patient's first isolation P. sequence type 1203 with carbapenemase gene blaVIM-80 and cephalosporinase blaGES-9 from any specimen collected reported to Centers for Disease Control Prevention during 1 January 2022–15 May 2023. conducted 1:1 matched case-control...
ABSTRACT Upon entry into stationary phase, bacteria dimerize 70S ribosomes translationally inactive 100S particles by a process called ribosome hibernation. Previously, we reported that the hibernation-promoting factor (HPF) of Listeria monocytogenes is required for particle formation and facilitates adaptation to number stresses. Here, demonstrate HPF high tolerance stationary-phase cultures aminoglycosides but not beta-lactam or quinolone antibiotics. The sensitivity Δ hpf mutant...
In August 2018, CDC noted an increased number of reports patients having symptoms clinically compatible with acute flaccid myelitis (AFM), a rare condition characterized by rapid onset weakness in one or more limbs and spinal cord gray matter lesions, compared 2017. Since 2014, has conducted surveillance for AFM using standardized case definition (1,2). An Epi-X* notice was issued on 23, to increase clinician awareness provide guidance reporting.
Carbapenem-resistant Enterobacterales (CRE) are a growing public health concern due to resistance multiple antibiotics and potential cause care-associated infections with high mortality. Carbapenemase-producing CRE of particular given that carbapenemase-encoding genes often located on mobile genetic elements may spread between different organisms species. In this study, we performed phenotypic genotypic characterization collected at eight U.S. sites participating in active population-...
Understanding the epidemiology of carbapenem-resistant A. baumannii complex (CRAB) and patients impacted is an important step toward informing better infection prevention control practices improving public health response.
Abstract Background Clostridioides difficile is a healthcare-associated pathogen recognized as the most common cause of infectious diarrhea in healthcare settings. PCR-based ribotyping, which employs heterogeneity ribosomal intergenic spacer region for discrimination, has historically been preferred method C. typing. However, ribotyping laborious and exhibits inter-laboratory variation significantly limits its utility universal typing scheme. The increasing adoption whole genome sequencing...
During exposure to certain stresses, bacteria dimerize pairs of 70S ribosomes into translationally silent 100S particles in a process called ribosome hibernation. Although the biological roles hibernation are not completely understood, this appears represent conserved and adaptive response that contributes optimal survival during stress post-exponential-phase growth. Hibernating formed by activity one or more highly proteins; gammaproteobacteria produce two relevant proteins, modulation...
Healthcare-associated carbapenem-resistant Acinetobacter baumannii (CRAB) infections are a serious threat associated with global epidemic clones and variety of carbapenemase gene classes. In this study, we describe the molecular epidemiology, including whole-genome sequencing analysis antimicrobial susceptibility profiles 92 selected, nonredundant CRAB collected through public health efforts in United States from 2013 to 2017. Among isolates, Oxford (OX) multilocus sequence typing scheme...
Abstract Background Antimicrobial susceptibility testing (AST) is not routinely performed for Clostridioides difficile and data evaluating minimum inhibitory concentrations (MICs) are limited. We AST whole genome sequencing (WGS) 593 C. isolates collected between 2012 2017 through the Centers Disease Control Prevention's Emerging Infections Program. Methods MICs to 6 antimicrobial agents (ceftriaxone, clindamycin, meropenem, metronidazole, moxifloxacin, vancomycin) were determined using...
Pre-mRNA splicing, the removal of noncoding intron sequences from pre-mRNA, is a critical reaction in eukaryotic gene expression. splicing carried out by remarkable macromolecular machine, spliceosome, which undergoes dynamic rearrangements its RNA and protein components to assemble catalytic center. While significant progress has been made describing "moving parts" this mechanisms spliceosomal proteins mediate ordered within spliceosome remain elusive. Here we explore recent evidence...
ABSTRACT Listeriolysin O (LLO) is a pore-forming toxin of the cholesterol-dependent cytolysin (CDC) family and primary virulence factor intracellular pathogen Listeria monocytogenes . LLO mediates rupture phagosomal membranes, thereby releasing bacteria into growth-permissive host cell cytosol. Several unique features allow its activity to be precisely regulated in order facilitate escape, growth, cell-to-cell spread. To improve our understanding multifaceted contribution pathogenesis L. ,...
Nontuberculous mycobacteria (NTM) cause pulmonary and extrapulmonary infections. Although isolation of NTM from clinical specimens has increased nationally, few studies delineated the molecular characteristics NTM.
ABSTRACT Enterococcus faecalis and faecium are frequent causes of healthcare-associated infections. Antimicrobial-resistant enterococci pose a serious public health threat, particularly vancomycin-resistant (VRE), for which treatment options limited. The Centers Disease Control Prevention’s Division Healthcare Quality Promotion Sentinel Surveillance system conducted surveillance from 2018 to 2019 evaluate antimicrobial susceptibility profiles molecular epidemiology 205 E. 180 clinical...
There is mounting evidence to suggest that the synthesis of pre-mRNA transcripts and their subsequent splicing are coordinated events. Previous studies have implicated mammalian spliceosomal U2 snRNP as having a novel role in stimulating transcriptional elongation vitro through interactions with factors P-TEFb Tat-SF1; however, mechanism remains unknown [1]. These conserved Saccharomyces cerevisiae, fact suggests similar interaction may occur yeast stimulate vivo. To address this possibility...
Without timely screening, diagnosis, and intervention, hearing loss can cause significant delays in a child's speech, language, social, emotional development. In 2019, Texas had nearly twice the average rate of to follow-up (LFU) or documentation (LTD; i.e., missing services received) among infants who did not pass their newborn screening compared United States overall (51.1 vs. 27.5%). We aimed identify factors contributing LFU/LTD do Texas.
On August 6, 2017, the Kosrae Department of Health Services in Federated States Micronesia reported a confirmed case mumps resident aged 18 years. The patient had documentation receipt 2 doses measles-mumps-rubella vaccine and recently traveled to Seattle, Washington, which was experiencing large outbreak among members its Pacific Islander population.
Ten
Abstract Repeated antigen testing of 12 severe acute respiratory coronavirus virus 2 (SARS-CoV-2)–positive nursing home residents using Abbott BinaxNOW identified 9 (100%) culture-positive specimens up to 6 days after initial positive test. Antigen positivity lasted 2–24 days. might last beyond the infectious period, but it was reliable in with evidence early infection.
Abstract Bacterial pathogenicity has traditionally focused on gene-level content with experimentally-confirmed functional properties. Hence, significant inferences are made based similarity to known pathotypes and DNA-based genomic subtyping for risk. Herein, we achieved de novo prediction of human virulence in Klebsiella pneumoniae by expanding genes spatially proximal gene discoveries linked domain architectures across all prokaryotes. This approach identified ontology functions not...
Vancomycin-resistant Staphylococcus aureus (VRSA) is a rare but serious public health concern. We describe VRSA case in North Carolina, USA. The isolate from the belonged to USA600 lineage and clonal complex 45. No transmission was identified. Confirmed cases should include thorough investigation response.