A5059146626- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- COVID-19 diagnosis using AI
- Mycobacterium research and diagnosis
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Infections and bacterial resistance
- Ginseng Biological Effects and Applications
- Infection Control in Healthcare
- Medical Device Sterilization and Disinfection
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 detection and testing
- Infectious Diseases and Mycology
- Urinary Tract Infections Management
- Veterinary medicine and infectious diseases
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Genomics and Phylogenetic Studies
- Tuberculosis Research and Epidemiology
Centers for Disease Control and Prevention
2016-2023
United States Department of Health and Human Services
2023
National Center for Emerging and Zoonotic Infectious Diseases
2017-2020
National Jewish Health
2019
University of Colorado Denver
2019
University of Iowa
2019
In the spring of 2015, investigators in Switzerland reported a cluster six patients with invasive infection Mycobacterium chimaera, species nontuberculous mycobacterium ubiquitous soil and water. The infected had undergone open-heart surgery that used contaminated heater-cooler devices during extracorporeal circulation (1). July Pennsylvania hospital also identified mycobacterial infections among patients. Similar to Swiss report, field investigation by Department Health, assistance from...
Carbapenem-resistant Enterobacterales (CRE) are a growing public health concern due to resistance multiple antibiotics and potential cause care-associated infections with high mortality. Carbapenemase-producing CRE of particular given that carbapenemase-encoding genes often located on mobile genetic elements may spread between different organisms species. In this study, we performed phenotypic genotypic characterization collected at eight U.S. sites participating in active population-...
Clinicians increasingly utilize polymyxins for treatment of serious infections caused by multidrug-resistant gram-negative bacteria. Emergence plasmid-mediated, mobile colistin resistance genes creates potential rapid spread polymyxin resistance. We investigated the possible transmission Klebsiella pneumoniae carrying mcr-1 via duodenoscope and report first documented healthcare mcr-1-harboring bacteria in United States.
Abstract A surgical heater–cooler unit has been implicated as the source for Mycobacterium chimaera infections among cardiac surgery patients in several countries. We isolated M. from units and patient United States. Whole-genome sequencing corroborated a risk these acting reservoir this pathogen.
ABSTRACT Eighty Gram-negative bacilli (54 Enterobacteriaceae and 26 nonfermenting bacilli) obtained from multiple institutions in the United States were distributed a blinded manner to seven testing laboratories compare their performance of test for detection carbapenemase production, Carba NP test. The was performed by all laboratories, following Clinical Laboratory Standards Institute (CLSI) procedure. Site-versus-site comparisons demonstrated high level consistency assay, with just 3/21...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of disease 2019 (COVID-19), has spread globally and is being surveilled with an international genome sequencing effort. Surveillance consists sample acquisition, library preparation, whole sequencing. This necessitated a classification scheme detailing Variants Concern (VOC) Interest (VOI), rapid expansion bioinformatics tools for sequence analysis. These bioinformatic are means major actionable results: maintaining...
In August of 2018, the United States Food and Drug Administration (FDA) announced a class I recall associated with methicillin-resistant Staphylococcus aureus (MRSA) safety alert. This was due to failure identify certain isolates as MRSA when using Gram-positive antimicrobial susceptibility testing (AST) cards Vitek 2 automated instrument (ATI) (1). To assist investigation, U.S. Centers for Disease Control Prevention (CDC) obtained 30 identified during initial from National Reference Center...
Abstract Background Contaminated healthcare facility wastewater plumbing is recognized as a source of carbapenemase-producing organism transmission. In August 2019, the Tennessee Department Health (TDH) identified patient colonized with Verona integron-encoded metallo-beta-lactamase-producing carbapenem-resistant Pseudomonas aeruginosa (VIM-CRPA). A record review revealed that 33% (4 12) all reported patients in VIM had history prior admission to acute care hospital (ACH) intensive unit...
Mycobacterium chimaera is a nontuberculous mycobacterium species commonly found in the environment. Here, we report first complete genome sequence of strain from investigation invasive infections following open-heart surgeries that used contaminated LivaNova Sorin Stockert 3T heater-cooler devices.
Four Enterobacteriaceae clinical isolates bearing mcr-1 gene-harboring plasmids were characterized. All demonstrated the ability to transfer colistin resistance Escherichia coli ; stable in conjugants after multiple passages on nonselective media.
Mycobacterium wolinskyi is a nonpigmented, rapidly growing nontuberculous mycobacterium species that associated with bacteremia, peritonitis, infections implants/prostheses, and skin soft tissue often following surgical procedures in humans. Here, we report the first functionally annotated draft genome sequence of M. CDC_01.
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as an important cause of healthcare-associated infections. We characterized the molecular epidemiology CRE in isolates collected through Emerging Infections Program (EIP) at Centers for Disease Control and Prevention (CDC). From 2011–2015, 8 U.S. EIP sites (CO, GA, MD, MN, NY, NM, TN OR) (Escherichia coli, Enterobacter aerogenes, cloacae complex, Klebsiella pneumoniae, oxytoca) isolated from a normally sterile site or urine. Isolates...
Background: Due to limited therapeutic options and potential for spread, carbapenem-resistant Enterobacteriaceae (CRE)-producing New Delhi metallo-β-lactamases (NDMs) are a public health priority. We investigated the epidemiology of NDM-producing CRE reported CDC clarify its distribution relative prevalence. Methods: The CDC’s Antibiotic Resistance Laboratory Network supports molecular testing 5 carbapenemases nationally. Although KPC is most common carbapenemase in United States, non-KPC...
Abstract Background In July 2018, the Arkansas Department of Health (ADH) was notified by hospital A 3 patients with bloodstream infections (BSIs) a rapidly growing nontuberculous Mycobacterium (NTM) species; on 5 September 6 additional BSIs were reported. All among oncology at clinic A. We investigated to identify sources and prevent further infections. Methods ADH performed an onsite investigation 7 2018 reviewed patient charts, obtained environmental samples, cultured isolates. The...
Background : Contaminated healthcare facility plumbing is increasingly recognized as a source of carbapenemase-producing organisms (CPOs). In August 2019, the Tennessee State Public Health Laboratory identified Tennessee’s twelfth VIM-producing carbapenem-resistant Pseudomonas aeruginosa (VIM-CRPA), from patient in long-term acute-care hospital. To determine potential reservoir, Department (TDH) reviewed exposures for all cases. Four cases (33%), including most recent case and earliest March...