A5009602937- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Salmonella and Campylobacter epidemiology
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Clostridium difficile and Clostridium perfringens research
- Animal Virus Infections Studies
- Neonatal and Maternal Infections
- Plant Pathogenic Bacteria Studies
- Viral Infections and Immunology Research
- Geriatric Care and Nursing Homes
- Microscopic Colitis
- Frailty in Older Adults
- Health disparities and outcomes
- Infection Control and Ventilation
- Health Systems, Economic Evaluations, Quality of Life
Centers for Disease Control and Prevention
2013-2024
CDC Foundation
2022-2023
Atlanta Research and Education Foundation
2004-2012
National Center for Immunization and Respiratory Diseases
2011-2012
National Center for Emerging and Zoonotic Infectious Diseases
2012
New Mexico Department of Health
2009
Colorado Department of Public Health and Environment
2009
New York State Department of Health
2009
Connecticut Department of Public Health
2009
Epidemic Intelligence Service
2009
Group B streptococcal disease is one of the most common infections in first week after birth. In 2002, national guidelines recommended universal late antenatal screening pregnant women for colonization with group streptococcus to identify candidates intrapartum chemoprophylaxis.
Carbapenem-resistant Enterobacteriaceae (CRE) are increasingly reported worldwide as a cause of infections with high-mortality rates. Assessment the US epidemiology CRE is needed to inform national prevention efforts.To determine population-based incidence and describe characteristics resistance mechanism associated isolates from 7 geographical areas.Population- laboratory-based active surveillance conducted among individuals living in 1 metropolitan areas Colorado, Georgia, Maryland,...
Efforts to prevent foodborne illness target bacterial pathogens, yet noroviruses (NoV) are suspected be the most common cause of gastroenteritis. New molecular assays allow for better estimation role NoV in illness. We analyzed 8,271 outbreaks reported Centers Disease Control and Prevention from 1991 2000 additional data 6 states. The proportion NoV-confirmed increased 1% 12% 2000. However, 1998 2000, 76% were by only 11 In an estimated 50% states attributable NoV. larger than (median...
In 2002, a sharp increase in outbreaks of norovirus-associated illness, both on cruise ships and land, encouraged us to examine the molecular epidemiology detected noroviruses, identify common strain or source. Of 14 laboratory-confirmed ships, 12 (86%) were attributed caliciviruses; among these 12, outbreak characteristics included continuation successive cruises 6 (50%), multiple modes transmission 7 (58%), high (>10%) attack rates (58%). Eleven calicivirus (64%) which previously...
Between July 2000 and June 2004, fecal specimens from 270 outbreaks of acute gastroenteritis were sent to the Centers for Disease Control Prevention by local or state health departments calicivirus testing. Of 226 that met criteria inclusion in present study, caliciviruses detected 184 (81%) reverse-transcription polymerase chain reaction nucleotide sequencing. Nursing homes, retirement centers, hospitals most frequently reported settings, person-to-person contact was common mode...
Typhoid fever in the United States has increasingly been due to infection with antimicrobial-resistant Salmonella ser Typhi. National surveillance for typhoid can inform prevention and treatment recommendations.To assess trends infections S. Typhi.Cross-sectional, laboratory-based study.We reviewed data from 1999-2006 1902 persons who had epidemiologic information submitted Centers Disease Control Prevention (CDC) 2016 Typhi isolates sent by participating public health laboratories...
Acute gastroenteritis (AGE) remains a common cause of clinic visits and hospitalizations in the United States, but etiology is rarely determined.We performed prospective, multicenter emergency department-based study adults with AGE. Subjects were interviewed on presentation 3-4 weeks later. Serum samples, rectal swab specimens, and/or whole stool specimens collected at presentation, serum was Fecal tested for comprehensive panel viral, bacterial, parasitic pathogens; calicivirus...
Abstract We describe an investigation of a norovirus gastroenteritis outbreak aboard cruise ship affecting 6 consecutive cruises and the use sequence analysis to determine modes virus transmission. Noroviruses (NoV), are most common cause infectious acute transmitted feco-orally through food water, directly from person by environmental contamination (1). These viruses often responsible for protracted outbreaks in closed settings, such as ships, nursing homes, hospitals (2,3).
USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates are usually resistant only to oxacillin, erythromycin, and, increasingly, levofloxacin. Of these, oxacillin and levofloxacin resistances chromosomally encoded. Plasmid-mediated clindamycin, mupirocin, and/or tetracycline resistance has been observed among isolates, but these descriptions were limited specific patient populations or isolated occurrences. We examined the antimicrobial susceptibilities of invasive MRSA from a...
Pseudomonas aeruginosa is intrinsically resistant to many antimicrobial drugs, making carbapenems crucial in clinical management. During July-October 2015 the United States, we piloted laboratory-based surveillance for carbapenem-resistant P. (CRPA) at sentinel facilities Georgia, New Mexico, Oregon, and Tennessee, population-based Monroe County, NY. An incident case was first isolate antipseudomonal from a patient 30-day period any source except nares, rectum or perirectal area, feces. We...
"Norwalk-like viruses" (NLVs) cause outbreaks of gastroenteritis and are spread frequently through contaminated food or water. Molecular diagnostics now enables detecting viruses in clinical environmental specimens, linking NLV strains causing multiple geographic locations, tracing them to their sources This report reviews recent advances detection provides guidelines recommendations for investigating NLV-related outbreaks, including specimen collection disease prevention control. also...
An increasing proportion of
Abstract Preventing transmission of carbapenemase-producing, carbapenem-resistant Enterobacteriaceae (CP-CRE) is a public health priority. A phenotype-based definition that reliably identifies CP-CRE while minimizing misclassification non–CP-CRE could help prevention efforts. To assess possible definitions, we evaluated enterobacterial isolates had been tested and deemed nonsusceptible to >1 carbapenem at US Emerging Infections Program sites. We determined the number non-CP met (false...
Abstract In healthcare settings, Acinetobacter spp. bacteria commonly demonstrate antimicrobial resistance, making them a major treatment challenge. Nearly half of organisms from clinical cultures in the United States are nonsusceptible to carbapenem drugs. During 2012–2015, we conducted laboratory- and population-based surveillance selected metropolitan areas Colorado, Georgia, Maryland, Minnesota, New Mexico, York, Oregon, Tennessee determine incidence carbapenem-nonsusceptible A....
Carbapenem-resistant Enterobacterales (CRE) are a growing public health concern due to resistance multiple antibiotics and potential cause care-associated infections with high mortality. Carbapenemase-producing CRE of particular given that carbapenemase-encoding genes often located on mobile genetic elements may spread between different organisms species. In this study, we performed phenotypic genotypic characterization collected at eight U.S. sites participating in active population-...
Understanding the epidemiology of carbapenem-resistant A. baumannii complex (CRAB) and patients impacted is an important step toward informing better infection prevention control practices improving public health response.
Background. From 2003 through 2007, Vibrio cholerae serogroup O75 strains possessing the cholera toxin gene were isolated from 6 patients with severe diarrhea, including 3 in Georgia, 2 Alabama, and 1 South Carolina. These reports represent first identification of V. as a cause illness United States. was water sample collected pond Louisiana 2004. Subsequently, isolates (2 diarrhea 2000 1978) that had been previously reported O141 also discovered to be O75. Results. All 8 who infected adults...
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The CDC's Emerging Infections Program (EIP) conducted population- and laboratory-based surveillance of US carbapenem-resistant Pseudomonas aeruginosa (CRPA) from 2016 through 2018. To characterize the pathotype, 1,019 isolates collected this project underwent antimicrobial susceptibility testing whole-genome sequencing. Sequenced genomes were classified using seven-gene multilocus sequence typing (MLST) scheme a core genome (cg)MLST was used to determine phylogeny. Both chromosomal...
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Background. The USA300 methicillin-resistant Staphylococcus aureus (MRSA) strain, which initially emerged as a cause of community-associated infections, has recently become an important pathogen in healthcare-associated infections (HAIs). However, its impact on patient outcomes not been well studied. We evaluated patients with invasive MRSA to assess differences between caused by USA100 and those USA300.
ABSTRACT We describe clinical and laboratory characteristics of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections with vancomycin MICs 2 μg/ml compare heteroresistant-intermediate S. (hVISA) to non-hVISA. Health care-associated community-onset were the most common resulted in frequent complications relapses. hVISA-infected patients more likely have been hospitalized year prior MRSA culture.