A5050695832- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Bacterial Identification and Susceptibility Testing
- Bacterial Infections and Vaccines
- Immunodeficiency and Autoimmune Disorders
- Psychoanalysis and Psychopathology Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- French Literature and Critical Theory
- Historical and Literary Analyses
- Infective Endocarditis Diagnosis and Management
- Historical and Literary Studies
- French Historical and Cultural Studies
- Clostridium difficile and Clostridium perfringens research
- Sepsis Diagnosis and Treatment
- Caribbean and African Literature and Culture
- Child and Adolescent Health
- American Sports and Literature
- Historical Studies and Socio-cultural Analysis
- Otolaryngology and Infectious Diseases
- American and British Literature Analysis
- Diverse Cultural and Historical Studies
Connecticut Department of Public Health
2016-2025
Vanderbilt University
2025
New York Proton Center
2016
Engineering Associates (United States)
2016
Connecticut Health Foundation
2006-2013
Hartford Financial Services (United States)
2004-2013
College of San Mateo
1985-2012
University of California, Irvine
2012
Yale University
2012
New Mexico Department of Health
2009
ContextAs the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on scope and magnitude MRSA in US population is needed.ObjectivesTo describe incidence distribution invasive disease 9 communities to estimate burden United States 2005.Design SettingActive, population-based surveillance for sites participating Active Bacterial Core (ABCs)/Emerging Infections Program Network from July 2004 through December 2005. Reports were...
3][4] Two recommended approaches for identifying chemoprophylaxis candidates were widely adopted in the United States and resulted substantial declines disease infants younger than 7 days (also known as early onset disease). 5,6n 2002, revised guidelines antenatal culture-based screening optimal method candidates. 7sease trends following release of these have not yet been well studied.In addition to illness first week life, group B streptococcus also causes invasive older infants, pregnant...
Staphylococcus aureus is one of the most common pathogens in health care facilities and community, can cause invasive infections, sepsis, death. Despite progress preventing methicillin-resistant S. (MRSA) infections settings, assessment problem both community settings needed. Further, epidemiology methicillin-susceptible (MSSA) not well described at national level.Data from Emerging Infections Program (EIP) MRSA population surveillance (2005-2016) Premier Cerner Electronic Health Record...
Invasive pneumococcal disease declined among children and adults after the introduction of pediatric heptavalent conjugate vaccine (PCV7) in 2000, but its effect on meningitis is unclear.We examined trends from 1998 through 2005 using active, population-based surveillance data eight sites United States. Isolates were grouped into PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, 23F), PCV7-related (6A, 9A, 9L, 9N, 18A, 18B, 18F, 19B, 19C, 23A, 23B), non-PCV7 (all others). Changes incidence assessed...
Estimating the US burden of methicillin-resistant Staphylococcus aureus (MRSA) infections is important for planning and tracking success prevention strategies.
Group B Streptococcus (GBS) and Escherichia coli have historically dominated as causes of early-onset neonatal sepsis. Widespread use intrapartum prophylaxis for GBS disease led to concerns about the potential adverse impact on E incidence.Active, laboratory, population-based surveillance culture-positive (blood or cerebrospinal fluid) bacterial infections among infants 0 2 days age was conducted statewide in Minnesota Connecticut selected counties California Georgia during 2005 2014....
Group B Streptococcus (GBS), traditionally considered to be a neonatal pathogen, is an important cause of morbidity and mortality among older adults those with underlying medical conditions. We used population-based surveillance examine trends in adult GBS disease during the period 1990-2007 describe epidemiology guide prevention efforts.
Group B streptococcal disease is one of the most common infections in first week after birth. In 2002, national guidelines recommended universal late antenatal screening pregnant women for colonization with group streptococcus to identify candidates intrapartum chemoprophylaxis.
Invasive group A Streptococcus (GAS) infections are associated with significant morbidity and mortality rates. We report the epidemiology trends of invasive GAS over 8 years surveillance.From January 2005 through December 2012, we collected data from Centers for Disease Control Prevention's Active Bacterial Core surveillance, a population-based network 10 geographically diverse US sites (2012 population, 32.8 million). defined as isolation normally sterile site or wound in patient...
In January 2005, a quadrivalent (serogroups A, C , Y, and W-135) meningococcal conjugate vaccine was licensed for use in adolescents. This report describes the epidemiologic features of disease United States from 1998 through December 2007, before during implementation adolescent vaccination.Data were collected active surveillance invasive Neisseria meningitidis conducted Active Bacterial Core (ABCs) sites 1998-2007. Isolates cases serogrouped at ABCs site confirmed Centers Disease Control...
<h3>Importance</h3> Invasive disease owing to group B<i>Streptococcus</i>(GBS) remains an important cause of illness and death among infants younger than 90 days in the United States, despite declines early-onset (EOD; with onset at 0-6 life) that are attributed intrapartum antibiotic prophylaxis (IAP). Maternal vaccines prevent infant GBS currently under development. <h3>Objective</h3> To describe incidence rates, case characteristics, antimicrobial resistance, serotype distribution EOD...
Group B Streptococcus (GBS) is an important cause of invasive bacterial disease. Previous studies have shown a substantial and increasing burden GBS infections among nonpregnant adults, particularly older adults those with underlying medical conditions.
Background. Athletics-associated methicillin-resistant Staphylococcus aureus (MRSA) infections have become a high-profile national problem with substantial morbidity. Methods. To investigate an MRSA outbreak involving college football team, we conducted retrospective cohort study of all 100 players. A case was defined as cellulitis or skin abscess diagnosed during the period 6 August (the start camp) through 1 October 2003. Results. We identified 10 patients (2 whom were hospitalized). The...
Abstract To determine frequency of methicillin-resistant Staphylococcus aureus infections caused by strains typically associated with community-acquired (USA300) among persons healthcare-related risk factors (HRFs), we evaluated surveillance data. Of patients HRFs, 18%–28% had a "community-associated" strain, primarily USA300; without 26% "healthcare-associated" USA100.
Intrapartum antibiotic prophylaxis for neonatal group B streptococcal disease (GBS) effectively prevents among infants <7 days old, but there are no prevention strategies late-onset GBS (onset on 7-89 of life). We describe trends in over a 16-year period to characterize burden and estimate vaccine preventability.We conducted active, population-based surveillance invasive 10 states from 1990 2005. A case was defined by isolation normally sterile site day life area resident. Incidence rates...
Background. With the introduction of Haemophilus influenzae serotype b (Hib) conjugate vaccines, there has been a dramatic reduction Hib disease in young children and epidemiological trends invasive H. have shifted.
ObjectivesOur objective was to evaluate and exploit a whole genome sequence (WGS) bioinformatics pipeline for predicting antimicrobial resistance capsular serotypes from invasive group B streptococci (iGBS).MethodsFor 1975 iGBS recovered during 2015 CDC's Active Bacterial Core surveillance, we compared predictions with broth dilution testing. Fifty-six isolates earlier surveillance were included testing β-lactams. Conventional serotyping WGS-based assignments 302 isolates.ResultsAll 28...
Antibiotic-nonsusceptible invasive pneumococcal disease (IPD) decreased substantially after the US introduction of pediatric 7-valent conjugate vaccine (PCV7) in 2000. However, rates antibiotic-nonsusceptible non-PCV7-type IPD increased during 2004-2009. In 2010, 13-valent (PCV13) replaced PCV7. We assessed impact PCV13 on rates.We defined as isolation from a normally sterile site resident 10 surveillance sites. isolates were those intermediate or resistant to ≥1 antibiotic classes according...
Following Haemophilus influenzae serotype b (Hib) conjugate vaccine introduction in the 1980s, Hib disease young children dramatically decreased, and epidemiology of invasive H. changed.
We examined associations between the socioeconomic characteristics of census tracts and racial/ethnic disparities in incidence bacteremic community-acquired pneumonia among US adults.
During 2000–2011, passive surveillance for legionellosis in the United States demonstrated a 249% increase crude incidence, although little was known about clinical course and method of diagnosis. In 2011, system active, population-based instituted through CDC’s Active Bacterial Core (ABCs) program. Overall disease rates were similar both active systems, but more complete demographic information additional laboratory data only available from ABCs. ABCs during 2011–2013 showed that...
Our whole genome sequence (WGS) pipeline was assessed for accurate prediction of antimicrobial phenotypes. For 2316 invasive pneumococcal isolates recovered during 2015 we compared WGS data to broth dilution testing (BDT) 18 antimicrobials. 11 antimicrobials categorical discrepancies were assigned when WGS-predicted MICs and BDT predicted different categorizations susceptibility, intermediate resistance or resistance, ranging from 0.9% (tetracycline) 2.9% (amoxicillin). β-lactam antibiotics,...
Streptococcus pneumoniae (pneumococcus) caused approximately 44000 US invasive pneumococcal disease (IPD) cases in 2008. Antibiotic nonsusceptibility complicates IPD treatment. Using penicillin susceptibility breakpoints adopted 2008, we evaluated antibiotic-nonsusceptible trends light of the introductions a 7-valent conjugate vaccine (PCV7) 2000 and 13-valent (PCV13) 2010.IPD were defined by isolation pneumococcus from normally sterile site individuals residing Active Bacterial Core...