A5017460877- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- Neonatal and Maternal Infections
- Otolaryngology and Infectious Diseases
- Infective Endocarditis Diagnosis and Management
- Data-Driven Disease Surveillance
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacillus and Francisella bacterial research
- Zoonotic diseases and public health
- Viral Infections and Outbreaks Research
- HIV, Drug Use, Sexual Risk
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- Food Security and Health in Diverse Populations
- Viral gastroenteritis research and epidemiology
- Disaster Response and Management
- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- Salmonella and Campylobacter epidemiology
National Center for Immunization and Respiratory Diseases
2013-2024
Centers for Disease Control and Prevention
2014-2024
CDC Foundation
2022-2023
Foundation Center
2022
Atlanta Research and Education Foundation
2022
Government of the United States of America
2021
United States Department of Health and Human Services
2020
University of Concepción
2020
The University of Adelaide
2020
Institute of Epidemiology, Disease Control and Research
2020
The guideline is intended for use by healthcare providers who care adult and pediatric patients with group A streptococcal pharyngitis. updates the 2002 Infectious Diseases Society of America discusses diagnosis management, recommendations are provided regarding antibiotic choices dosing. Penicillin or amoxicillin remain treatments choice, made penicillin-allergic patient, which now include clindamycin.
Invasive group A Streptococcus (GAS) infection causes significant morbidity and mortality in the United States. We report current epidemiologic characteristics of invasive GAS infections estimate potential impact a multivalent vaccine.From January 2000 through December 2004, we collected data from Centers for Disease Control Prevention's Active Bacterial Core surveillance (ABCs), population-based system operating at 10 US sites (2004 population, 29.7 million). defined case disease as...
Abstract The guideline is intended for use by healthcare providers who care adult and pediatric patients with group A streptococcal pharyngitis. updates the 2002 Infectious Diseases Society of America discusses diagnosis management, recommendations are provided regarding antibiotic choices dosing. Penicillin or amoxicillin remain treatments choice, made penicillin-allergic patient, which now include clindamycin.
Invasive group A Streptococcus (GAS) infections are associated with significant morbidity and mortality rates. We report the epidemiology trends of invasive GAS over 8 years surveillance.From January 2005 through December 2012, we collected data from Centers for Disease Control Prevention's Active Bacterial Core surveillance, a population-based network 10 geographically diverse US sites (2012 population, 32.8 million). defined as isolation normally sterile site or wound in patient...
Significance Epidemics of microbial infections are a considerable threat to human and animal health. Analysis 3,615 genome sequences, coupled with virulence studies in animals, permitted us delineate the nature timing molecular events that contributed an ongoing global epidemic caused by group A Streptococcus , “flesh-eating” pathogen. We clarified decades-long uncertainty about sequence genomic alterations underpinned epidemic. Analyses this type crucial for developing better strategies...
Group A Streptococcus (GAS) infections result in a considerable underappreciated burden of acute and chronic disease globally. 2018 World Health Assembly resolution calls for better control prevention. Providing guidance on global health research needs is an important Organization (WHO) activity, influencing prioritization investments. Here, the role, status, directions GAS vaccines are discussed. WHO preferred product characteristics development technology roadmap, briefly presented, offer...
Beta-hemolytic streptococci of groups other than A and B (NABS) are increasingly recognized as causes clinically significant disease, but precise information about this heterogeneous group is lacking. We report the incidence NABS infection describe epidemiologic clinical characteristics.Active, population-based surveillance for invasive was performed over a 2-year period in 8-county metropolitan Atlanta, Georgia, area 3-county San Francisco Bay, California, area. Clinical records were...
Background. The epidemiology of streptococcal infection in pregnant and postpartum women is poorly described recent literature. We used data from multistate surveillance for invasive Streptococcus pneumoniae, group A (GAS), B (GBS) infections to estimate disease incidence severity these populations.
ABSTRACT Group A streptococci (GAS) are genetically diverse. Determination of strain features can reveal associations with disease and resistance assist in vaccine formulation. We employed whole-genome sequence (WGS)-based characterization 1,454 invasive GAS isolates recovered 2015 by Active Bacterial Core Surveillance performed conventional antimicrobial susceptibility testing. Predictions were made for genotype, carbohydrate, resistance, surface proteins (M family, fibronectin binding, T,...
Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin 8-fold higher, the MIC cefotaxime was 3-fold higher than near-isogenic control isolates, consistent first step in developing β-lactam resistance.
][4][5] In January 1996, public health officials in Oregon and British Columbia independently noted marked increases reported Salmonella enterica serotype Newport (SN) infections.Routine notification of surrounding states provinces led to the recognition this coincidence.The resulting coordinated epidemiologic investigation identified a common source outbreak.Discussions with epidemiologists at Centers for Disease Control Prevention (CDC) retrospective identification large previously...
Estimates of disease burden and data on the sources invasive postpartum group A streptococcus (GAS) infections will help guide public health action. Active, population-based surveillance was conducted in 9 regions from 1995 through 2000. case GAS infection defined as isolation a sterile site resident area who pregnant or period. Census live birth were used to calculate rates. Eighty-seven cases (2.2% 3957 infections) occurred at 3%-8% hospitals annually. We estimate that 220 annually United...
Abstract Background Treatment of severe group A Streptococcus (GAS) infections requires timely and appropriate antibiotic therapy. We describe the epidemiology antimicrobial-resistant invasive GAS (iGAS) in United States (US). Methods analyzed population-based iGAS surveillance data at 10 US sites from 2006 through 2017. Cases were defined as infection with isolated normally sterile or wounds patients necrotizing fasciitis streptococcal toxic shock syndrome. isolates emm typed. Antimicrobial...
Reported outbreaks of invasive group A Streptococcus (iGAS) infections among people who inject drugs (PWID) and experiencing homelessness (PEH) have increased, concurrent with rising US iGAS rates. We describe epidemiology patients these risk factors.We analyzed from population-based Active Bacterial Core surveillance (ABCs) at 10 sites 2010 to 2017. Cases were defined as GAS isolated a normally sterile site or wound in necrotizing fasciitis streptococcal toxic shock syndrome. isolates emm...
Nasopharyngeal carriage of Streptococcus pneumoniae is extremely prevalent in The Gambia. We studied the effects vaccination with pneumococcal conjugate vaccines on individual serotypes and antimicrobial resistance vaccinated children their younger siblings.A longitudinal study a subsample (n=2342) who participated randomized, placebo controlled trial 9-valent (PCV-9) Gambia, cross-sectional non-PCV-9-vaccinated siblings (n=675).Recipients PCV-9 were less likely to carry vaccine 4, 6B, 9V,...
Beta-hemolytic group C and G streptococci cause a considerable invasive disease burden sometimes outbreaks. Little is known about the critical epidemiologic parameter of genetic relatedness between isolates. We determined emm types 334 Streptococcus dysgalactiae subsp. equisimilis isolates, attempted typing 5 canis isolates from recent population-based surveillance for Thirty-four were observed, including one S. canis. formulated multilocus sequence (MLST) primers with six seven loci...
Active Bacterial Core surveillance (ABCs) was established in 1995 as part of the Centers for Disease Control and Prevention Emerging Infections Program (EIP) network to assess extent invasive bacterial infections public health importance. ABCs is distinctive among systems because its large, population-based, geographically diverse catchment area; active laboratory-based identification cases ensure complete case capture; detailed collection epidemiologic information paired with laboratory...
During 2014-2017, CDC Emerging Infections Program surveillance data reported that the occurrence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections associated with injection drug use doubled among persons aged 18-49 years residing in Monroe County western New York.*Unpublished also indicate an increasing proportion all Candida spp.bloodstream and group A Streptococcus (GAS) 15 York counties are occurring who inject drugs.In addition, across six sites nationwide, MRSA...
The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use. network was established strengthen surveillance laboratory confirmation of meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis.
Group C and G Streptococcus dysgalactiae subspecies equisimilis (GCSE GGSE) cause a substantial percentage of invasive disease caused by beta-hemolytic streptococci. To determine whether pyogenes superantigen (SAg) genes commonly exist within these organisms, 20 recent GCSE GGSE human isolates one group canis isolate were tested for the presence SAg speH, speJ, speL, speM, ssa smeZ polymerase chain reaction (PCR). Prior to this work, sequence-based evidence ssa, in GCSE, GGSE, S. had not...