A5045094628- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Antimicrobial Resistance in Staphylococcus
- Respiratory viral infections research
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Neonatal and Maternal Infections
- Respiratory and Cough-Related Research
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Child and Adolescent Health
- Antibiotic Use and Resistance
- Child Nutrition and Water Access
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Breastfeeding Practices and Influences
- Otolaryngology and Infectious Diseases
- Endometrial and Cervical Cancer Treatments
- Global Maternal and Child Health
- COVID-19 Impact on Reproduction
- Listeria monocytogenes in Food Safety
- Poxvirus research and outbreaks
- Pharmaceutical studies and practices
Fairfax County Park Authority
2019-2023
Rush University Medical Center
2021-2023
State University of New York
1999-2021
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2020-2021
Northwell Health
2020-2021
SUNY Downstate Health Sciences University
2020-2021
South Shore Hospital
2020
George Mason University
2019
Northwell Health Orthopaedic Institute
2019
Los Angeles County Department of Public Health
2015-2019
Intussusception is a form of intestinal obstruction in which segment the bowel prolapses into more distal segment. Our investigation began on May 27, 1999, after nine cases infants who had intussusception receiving tetravalent rhesus–human reassortant rotavirus vaccine (RRV-TV) were reported to Vaccine Adverse Event Reporting System.
Several reports suggest that the incidence of invasive group A streptococcal infections, including toxic shock syndrome and necrotizing fasciitis, is increasing.
Twenty-one consecutive patients with streptococcal toxic shock syndrome (TSS) between December 1994 and April 1995 were treated a median dose of 2 g intravenous immunoglobulin (IVIG)/kg (cases) compared 32 TSS 1992 who did not receive IVIG therapy (controls). The outcome measure was 30-day survival. Patient plasma tested for its ability to inhibit T cell activation induced by the infecting strain. proportion cases survival higher than that controls (67% vs. 34%, respectively; P = .02)....
Objective. Respiratory syncytial virus (RSV), influenza virus, and parainfluenza viruses (PIV) cause significant morbidity in young children. Although only infection illness is currently vaccine-preventable, vaccines are under development for RSV PIV. We established a prospective, active population-based surveillance network to provide precise estimates of hospitalization rates viral acute respiratory (ARI) children measure the potential impact enhanced vaccine usage on these rates. Methods....
Objective. To provide consensus recommendations for the management of acute otitis media (AOM) and surveillance drug-resistant Streptococcus pneumoniae (DRSP). Five questions were addressed: (1) Can amoxicillin remain best initial antimicrobial agent treating AOM in current period increasing prevalence DRSP? (2) What are suitable alternative agents use if fails? (3) Should empiric treatment vary by geographic region? (4) Where can clinicians learn about resistance patterns their patient...
During spring 2005, two tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) products formulated for use in adolescents (and, one product, adults) were licensed the United States (BOOSTRIX, GlaxoSmithKline Biologicals, Rixensart, Belgium [licensed May 3, persons aged 10-18 years], ADACEL, sanofi pasteur, Toronto, Ontario, Canada June 10, 11-64 years]). Prelicensure studies demonstrated safety efficacy against tetanus, diphtheria, when Tdap was administered as a...
Severe invasive group A streptococcal (GAS) disease is believed to have reemerged during the past 10–20 years. We conducted active, laboratory, population-based surveillance in 5 US states (total population, 13,214,992). From 1 July 1995 through 31 December 1999, we identified 2002 episodes of GAS (3.5 cases per 100,000 persons). Rates varied by age (higher among those <2 or ⩾65 years old), area, and race black individuals) but did not increase study period. The most common emm types (1, 28,...
Otitis media is the leading indication for outpatient antimicrobial use in United States. Overdiagnosis of and unnecessary prescribing this condition has contributed to spread resistance. A critical step reducing identify subset patients who are unlikely benefit from antibiotics. Conscientiously distinguishing acute otitis (AOM) with effusion (OME), deferring antibiotics OME will accomplish goal, avoid up 8 million courses annually. Criteria defining these conditions presented, as well...
Objective. To examine the attitudes, beliefs, and behaviors of parents whose children were underimmunized with respect to ≥2 vaccines that have recently received negative attention, compared fully immunized recommended vaccines. Design. Case-control study. Setting. A sample households participated in National Immunization Survey recontacted 2001. Main Outcome Measure. Vaccination status was assessed. Case subjects 3 (diphtheria-tetanus-pertussis or diphtheria-tetanus-acellular pertussis,...
An outbreak of severe pneumococcal pneumonia among children occurred in Iowa from November 1995 through January 1996. associated influenza disease was predominantly caused by A (H1N1) for the first time since 1989. We conducted a case-control study to determine whether preceding infection directly with illness. identified 13 pneumonia. Patients were more likely than control subjects report experiencing an influenza-like illness 7-28 days admission (matched odds ratio [OR], 12.4; 95%...
This article introduces a set of principles to define judicious antimicrobial use for five conditions that account the majority outpatient in United States. Data from National Center Health Statistics indicate recent years, approximately three fourths all antibiotics have been prescribed otitis media, sinusitis, bronchitis, pharyngitis, or nonspecific upper respiratory tract infection.1Antimicrobial drug rates are highest children1; therefore, pediatric age group represents focus present...
This report is a revision of General Recommendations on Immunization and updates the 1994 statement by Advisory Committee Practices (ACIP) (CDC. recommendations immunization: [ACIP]. MMWR 1994;43[No. RR-1]:1-38). The principal changes include expansion discussion vaccination spacing timing, for vaccinations administered an incorrect route, information regarding needle-free injection technology, children adopted from countries outside United States, timing live-virus tuberculosis screening,...
Streptococcus pneumoniae is a leading cause of fatal bacterial pneumonia in young children. Pneumococcal polysaccharide vaccines have not been promoted for use children because many constituent serotypes are immunogenic < 2 years old. Conjugating pneumococcal epitopes to protein carrier would likely increase vaccine immunogenicity We reviewed published and unpublished serotype serogroup data from 16 countries on 6 continents determine geographic temporal differences distribution sterile site...
We compared the rates of detection respiratory viruses by reverse-transcription polymerase chain reaction (RT-PCR) and conventional viral culture in 668 combined nasal throat samples from a prospective, multicenter, population-based study acute tract infections among hospitalized children aged <5 years. RT-PCR increased yield identification 2-fold, with that alone. The sensitivity will better estimates population burden infections.
Objective. To identify risk factors for invasive pneumococcal disease, including penicillin-resistant infections, among children 2 to 59 months of age. Design. Case–control study. Participants. Patients with infections identified by population-based surveillance (n = 187) and controls through random-digit telephone dialing 280). Outcome measures. Invasive disease was defined as isolation Streptococcus pneumoniae from a normally sterile site. age who were residents one four active areas...
Background. In response to the dramatic emergence of resistant pneumococci, more judicious use antibiotics has been advocated. Physician beliefs, their prescribing practices, and attitudes patients have evaluated previously in separate studies. Methods. This 3-part study included a statewide mailed survey, office chart reviews, parent telephone interviews. We compared survey responses 366 licensed pediatricians family physicians Georgia recently published recommendations on diagnosis...
GROUP A streptococcus (<i>Streptococcus pyogenes</i>) may cause a variety of illnesses ranging from very common, usually clinically mild conditions such as pharyngitis and impetigo to less common severe infections including septicemia pneumonia. In 1987, Cone et al<sup>1</sup>described two patients with group streptococcal having clinical features similar the staphylococcal toxic shock syndrome. This syndrome, designated "streptococcal shock—like syndrome" or "toxic syndrome,"<sup>2</sup>was...