A5069822862- Toxoplasma gondii Research Studies
- Antibiotic Use and Resistance
- Cytomegalovirus and herpesvirus research
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- COVID-19 and Mental Health
- Patient Satisfaction in Healthcare
- SARS-CoV-2 detection and testing
- Forensic Toxicology and Drug Analysis
- COVID-19 epidemiological studies
- Bacterial Identification and Susceptibility Testing
- Genetics, Aging, and Longevity in Model Organisms
- Cellular transport and secretion
- Rabies epidemiology and control
- Herpesvirus Infections and Treatments
- HIV, Drug Use, Sexual Risk
- Mitochondrial Function and Pathology
- Opioid Use Disorder Treatment
- Insects and Parasite Interactions
- Antibiotic Resistance in Bacteria
- Hemoglobin structure and function
- Polyamine Metabolism and Applications
CDC Foundation
2022-2025
Centers for Disease Control and Prevention
2019-2023
National Center for Emerging and Zoonotic Infectious Diseases
2023
Epidemic Intelligence Service
2019-2021
University of Michigan–Ann Arbor
2014-2021
Center for Surveillance, Epidemiology, and Laboratory Services
2021
Ministry of Health and Welfare
2019
Virginia Department of Health
2019
Georgia Department of Public Health
2019
National Institute for Occupational Safety and Health
2019
In December 2019, a cluster of cases pneumonia emerged in Wuhan City central China's Hubei Province. Genetic sequencing isolates obtained from patients with identified novel coronavirus (2019-nCoV) as the etiology (1). As February 4, 2020, approximately 20,000 confirmed had been China and an additional 159 23 other countries, including 11 United States (2,3). On January 17, CDC U.S. Department Homeland Security's Customs Border Protection began health screenings at airports to identify ill...
ABSTRACT The protozoan parasite Toxoplasma gondii resides within a nonfusogenic vacuole during intracellular replication. Although the limiting membrane of this provides protective barrier to acidification and degradation by lysosomal hydrolases, it also physically segregates from host cytosol. Accordingly, has been suggested that T. acquires material via channels or transporters. ability internalize macromolecules endocytosis replication not tested. Here, we show ingests cytosolic proteins...
The impact of coronavirus disease 2019 (COVID-19) on antimicrobial use (AU) and resistance has not been well evaluated in South America. These data are critical to inform national policies clinical care.
Abstract Mutations in the him-5 gene Caenorhabditis elegans strongly reduce frequency of crossovers on X chromosome, with lesser effects autosomes. mutants also show a change crossover distribution both and These phenotypes are accompanied by delayed entry into pachytene premature desynapsis chromosome. The nondisjunction, progression defects can be rescued an exogenous source double strand breaks (DSBs), indicating that role HIM-5 is to promote formation meiotic DSBs. Molecular cloning...
Host cytosolic proteins are endocytosed by Toxoplasma gondii and degraded in its lysosome-like compartment, the vacuolar compartment (VAC), but dynamics route of endocytic trafficking remain undefined. Conserved components plant-like features suggest T. involves transit through early late endosome-like compartments (ELCs) potentially trans-Golgi network (TGN) as plants. However, exocytic to regulated secretory organelles, micronemes rhoptries, also proceeds ELCs requires classical...
During 2014-2017, CDC Emerging Infections Program surveillance data reported that the occurrence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections associated with injection drug use doubled among persons aged 18-49 years residing in Monroe County western New York.*Unpublished also indicate an increasing proportion all Candida spp.bloodstream and group A Streptococcus (GAS) 15 York counties are occurring who inject drugs.In addition, across six sites nationwide, MRSA...
Abstract Background In 2019, an estimated 1.27 million deaths were attributed to bacterial antimicrobial resistance (AR) globally. During the Coronavirus Disease 2019 (COVID-19) Pandemic, additional strain was placed on healthcare systems that may have led further increases in AR. We evaluated AR prevalence before and after onset of COVID-19 6 facilities (HCF) South America. Methods conducted ecological evaluation HCF-wide 4 private 2 public HCFs Argentina, Brazil, Chile; per country....
Calcium sensing receptor (CaSR) mutations implicated in familial hypocalciuric hypercalcemia, pancreatitis and idiopathic epilepsy syndrome map to an extended arginine-rich region the proximal carboxyl terminus. Arginine-rich motifs mediate endoplasmic reticulum retention and/or retrieval of multisubunit proteins so we asked whether these mutations, R886P, R896H or R898Q, altered CaSR targeting plasma membrane. Targeting was enhanced by all three Ca2+-stimulated ERK1/2 phosphorylation...
Psittacosis is typically a mild febrile respiratory illness caused by infection with the bacterium Chlamydia psittaci and usually transmitted to humans infected birds (1).On average, 11 psittacosis cases per year were reported in United States during 2000-2017.During August-October 2018, largest U.S. outbreak 30 years (82 identified*) occurred two poultry slaughter plants, one each Virginia Georgia, that shared source farms (2).CDC used C. real-time polymerase chain reaction (PCR) test 54...
The intracellular parasite
Abstract Background High rates of antibiotic use (AU) among inpatients with coronavirus disease 2019 (COVID-19) despite low bacterial coinfection and secondary infection have been reported. We evaluated the impact COVID-19 pandemic on AU in healthcare facilities (HCFs) South America. Methods conducted an ecologic evaluation inpatient adult acute care wards 2 HCFs each Argentina, Brazil, Chile. The for intravenous antibiotics were calculated as defined daily dose per 1000 patient-days, using...
The coronavirus disease 2019 (COVID-19) pandemic may have impacted outpatient antibiotic prescribing in low- and middle-income countries such as Brazil. However, Brazil, particularly at the prescription level, is not well-described.We used IQVIA MIDAS database to characterize changes rates of antibiotics commonly prescribed for respiratory infections (azithromycin, amoxicillin-clavulanate, levofloxacin/moxifloxacin, cephalexin, ceftriaxone) among adults Brazil overall stratified by age sex,...
Abstract Background Reports showing high rates of antibiotic use (AU) in patients with coronavirus disease 2019 (COVID-19) despite low secondary bacterial infection have emerged from various countries across the globe. We evaluated impact COVID-19 pandemic on AU healthcare facilities (HCFs) Argentina, Brazil, and Chile. Methods conducted an ecologic evaluation inpatient adult acute care wards (excluding maternity wards) 6 HCFs Chile; 2 per country. data for intravenously administered...
ABSTRACT The intracellular parasite Toxoplasma gondii resides within a membrane bound parasitophorous vacuole (PV) and secretes an array of proteins to establish this replicative niche. It has been shown previously that both kinases numerous are phosphorylated after secretion. Here we assess the role phosphorylation SFP1 related GRA29, two secreted with unknown function. We show form stranded structures in PV independent described intravacuolar network or actin. GRA29 likely acts as seed for...
Background The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), evolved rapidly in the United States. This report describes demographic, clinical, and epidemiologic characteristics of 544 U.S. persons under investigation (PUI) for COVID-19 with complete SARS-CoV-2 testing beginning stages pandemic from January 17 through February 29, 2020. Methods In this surveillance cohort, Centers Control Prevention (CDC) provided consultation to...
Background: The coronavirus disease 2019 (COVID-19) pandemic severely affected Southeast Asia, with >35 million cases and ~360,000 deaths. Despite relatively low rates of secondary bacterial infection among inpatients COVID-19, several countries reported increased antibiotic use; raising concerns for worsening antimicrobial resistance. We assessed the impact COVID-19 on use antibiotics commonly used to treat respiratory infections in Asia. Methods: evaluated intravenous hospitalized...
Abstract Background Psittacosis is a respiratory illness caused by Chlamydia psittaci. The most commonly available diagnostic tests are serologic tests, which have low sensitivity and can cross-react with other chlamydial species. Serologic also require paired sera collected weeks apart, impractical for patient management. Real-time polymerase chain reaction (rtPCR) testing C. psittaci rapid, sensitive, specific. However, rtRCR only at the CDC Respiratory Diseases Branch laboratory,...