BACKGROUND: Tuberculous meningitis is the most severe manifestation of tuberculosis. The diagnostic approach tuberculous difficult. Combination clinical, laboratory and radiological criteria were used in meningitis. Urinary mycobacterial lipoarabinomannan (LAM) antigen detection a promising tool. Detection concentrated urine sample predicted to improve positivity rate qualitative enzyme-linked immunosorbent assay (ELISA) purpose this study examine ability monoclonal antibody ELISA...

Purpose: The coronavirus disease (COVID-19) outbreak has created a global health crisis. Secondary pulmonary bacterial infection is COVID-19 complication, increasing morbidity and mortality. This study aimed to determine the pathogens, antibiotic susceptibility patterns, risk factors for mortality in hospitalized patients. Patients Methods: retrospective used secondary data from patients' electronic medical records at Hasan Sadikin General Hospital Santo Borromeus between March 2020 2021....

Purpose: Omicron is a variant with the highest number of mutations among all Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) viruses, making whole genome sequencing (WGS) an essential tool for public health surveillance and molecular epidemiology. It important to note that data can provide insights into virus evolution disease control. This study aims overview WGS results SARS-CoV-2 Variant at Hasan Sadikin General Hospital Bandung. Patients Methods: was conducted using...

Tuberculosis (TB) remains a global public health problem. The determination of tuberculosis infection (TBI) using interferon-gamma release assay has now been used widely. We aim to evaluate the positivity rates Standard E TB-Feron enzyme-linked immunosorbent (TB-Feron ELISA) and F fluorescent immunoassay FIA) their agreement with QuantiFERON-TB Gold Plus (QFT-Plus) among TB high-risk populations in Bandung City, Indonesia. conducted cross-sectional study, including people high risk acquiring...

Background Rifampicin-resistant tuberculosis (RR-TB) is largely underdetected in Indonesia. Xpert MTB/RIF (Xpert) has recently been introduced, prioritizing patients at risk of RR-TB, followed by phenotypic drug-susceptibility (DST) if rifampicin resistance detected. Objective This study investigated Xpert-based management presumptive RR-TB cases under routine practice West Java, Methods We examined all records tested with the referral hospital for Java 2015–2016. measured loss across a...

In Indonesia, drug resistance testing for TB largely relies on Xpert MTB/RIF, and it is unknown what proportion of drug-resistant (DR) adequately diagnosed treated.

Introduction: We aim to describe the performance of combined IgM and IgG point-of-care antibody test (POC-Ab) (Wondfo®) compared real-time reverse transcriptase (rRT-PCR) (Allplex™ 2019-nCoV Assay) in detecting coronavirus disease 2019 (COVID-19).
 Methodology: POC-Ab with rRT-PCR results among patients a tertiary hospital from January March 2020 Bandung, Indonesia. selected presumptive COVID-19 positive consecutively 20 negative were randomly same group as controls. described...

Setiap serotipe virus dengue dapat menimbulkan manifestasi klinis mulai dari demam (DD) sampai berdarah (DBD) dan sindrom syok (SSD). Sulit untuk menilai karakteristik hasil hematologi yang khas setiap serotipe. Tujuan penelitian ini menentukan gambaran DD, DBD, SSD serta pemeriksaan rutin yaitu hemoglobin, hematokrit, leukosit, trombosit pada dengue. Penelitian dilakukan di Rumah Sakit Dr. Hasan Sadikin Bandung sejak Maret 2010 Juli 2011. Subjek adalah penderita infeksi usia >14 tahun...

Chronic pulmonary fungal infections may occur in patients with previous history of tuberculosis (TB), and are often clinically misclassified as TB, especially when bacteriological confirmation for Mycobacterium is absent. In this study, we investigated the prevalence antibody against Histoplasma capsulatum Aspergillus fumigatus confirmed chronic TB. Antibodies H. A. were measured from serum samples using enzyme-linked immunosorbent assay (ELISA). The presence M. sputum was smear microscopy,...

Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared clinical characteristics and laboratory parameters coronavirus disease 2019 (COVID-19) patients without DM estimated effect on mortality among COVID-19 patients. A retrospective cohort study collecting patients' demographic, characteristics, treatment outcomes from medical records was conducted a hospital Bandung City March to December 2020. Univariable...

Background: Indonesia has the second-highest tuberculosis prevalence in world. Moreover, is among 30 countries with highest burden of multidrug-resistant (MDR-TB). This study aimed to determine pattern second-line anti-tuberculosis drug resistance MDR-TB patients.Method: was a descriptive cross-sectional using data from patients aged 18 years and older, diagnosed drug-resistant TB at Dr. Hasan Sadikin General Hospital December 2021 June 2022. Total sampling used. Data on age, gender, history...

Tuberculosis (TB) is an infectious disease and one of the biggest causes death worldwide. The main problem today lack accurate rapid tests to detect Mycobacterium tuberculosis (MTB). Several molecular methods have been developed MTB. GeneXpert MTB/RIF® can MTB rifampicin resistance simultaneously in <2 hours. Cross Priming Amplification (CPA) isothermal amplification assay that Both these are so they faster. This study aims evaluate concordance results with CPA at Hasan Sadikin General...

We aimed to compare the clinical severity and outcome among laboratory-confirmed Omicron variant cases admitted between January December 2022. This is a cross-sectional study conducted in Hasan Sadikin General Hospital enrolled patients aged ≥18 years with omicron infection. Data was collected from records whole genome sequencing database. compared risk of severe symptoms mortality, using logistic regression analysis adjusted for sex, age, comorbidities, vaccination status. 255 main...

Severe and critical COVID-19 patients are known to experience hyperinflammatory conditions endothelial damage primarily characterized by increased levels of IL-6 D-dimer. This group is also considered at risk experiencing hemostasis disorders including decreased platelet counts, prolonged PT APTT, as well fibrinogen. Therefore, this study aimed determine the correlation between D-dimer in severe patients. The relationship other parameters such count, PT, fibrinogen were analyzed. A...

Plasma leakage, thrombocytopenia, and cytokines play roles in pathogenesis of dengue infection. Thrombocytopenia correlates with severity the disease. Dengue virus infection produces that stimulate C-Reactive Protein (CRP). This study aims to describe results CRP platelet counts paediatric inpatient at Hasan Sadikin Hospital Bandung. is a descriptive observational retrospective, cross-sectional data collection January 1-December 31, 2021 Hospital. From 32 total subjects, there were 24(75%)...

Hospital acquired pneumonia (HAP) is significantly impact the patient morbidity and mortality that cause etiologic identification becomes a microbiological emergency in HAP. The based on onset of important to determine specific pathogens, prognosis prevent bacteremia. aim study know bacterial profile antibiotic susceptibility pattern early HAP by determination, late with bacteriaemia intensive care setting. design this was retrospective descriptive. data collected from Clinical Microbiology...

Introduction. Mutation of SARS-CoV-2 has generated several variants concern (VOC) which spread promptly worldwide. These emerging affected global strategies to overcome COVID-19. Variants are determined by the whole genome sequencing (WGS) assay, is time-consuming, with limited availability (only in laboratories). Hence, a faster and more accessible examination needed. The single-nucleotide polymorphism (SNP) method one options for genomic variation surveillance that can help provide an...

Background: In Indonesia, drug resistance testing for TB largely relies on Xpert MTB/RIF, and it is unknown what proportion of drug-resistant (DR) adequately diagnosed treated.Methods: We conducted a cascade care analysis cohort presumptive rifampicin-resistant (RR) patients in tertiary hospital 2015-2018. Estimates incidences time delays consecutive steps were derived from global reports, national electronic registers, medical records. described secondary receiving treatment not supported...

Indonesia is the 2nd country with highest tuberculosis (TB) caseload in world. Inappropriate TB treatment may lead to multidrug-resistance (MDR-TB) development. rapid detection important, and very much needed, prevent transmission deaths due this disease. The Xpert® MTB/RIF proposed address problem. This study aimed assess performance of test West Java, Indonesia. was a cross-sectional conducted on MDR-TB suspects referred Dr. Hasan Sadikin General Hospital Bandung, Indonesia, using data...

Measuring COVID-19 incidence among hospital staff and the influencing factors preventative measures affecting outcomes is important given their high risk of exposure potential impacts on health service provision. Study participants included all with confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR) from March 2020 to July 2021. Data were collected age, gender, occupation, working area, symptoms vaccination status. We also data pediatric oncology patients...

Hematuria can be found in diabetic kidney disease. Urinary erythrocytes morphology differentiate hematuria disease from other glomerular disorders. Different etiologies need different management. Urinalysis with flowcytometry method directly give information about urine erythrocyte which is not obtained by the conventional method. The aim of this study was to determine proportion urinary isomorphic This a descriptive cross-sectional Dr. Hasan Sadikin Hospital Bandung July 2016 2017. Subjects...