A5082768843- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- COVID-19 diagnosis using AI
- Diabetes Management and Education
- Public Health and Nutrition
- Amoebic Infections and Treatments
- Medication Adherence and Compliance
- Bone and Dental Protein Studies
- Image Processing Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Long-Term Effects of COVID-19
- Galectins and Cancer Biology
- SARS-CoV-2 and COVID-19 Research
- Chronic Disease Management Strategies
- SARS-CoV-2 detection and testing
- Infectious Diseases and Mycology
- Healthcare Quality and Satisfaction
Padjadjaran University
2015-2025
Radboud University Nijmegen
2019-2023
Radboud University Medical Center
2019-2023
Indonesian Pediatric Society
2023
London School of Hygiene & Tropical Medicine
2020
A 9-month regimen of isoniazid can prevent active tuberculosis in persons with latent infection. However, the has been associated poor adherence rates and toxic effects.
Abstract Background Diabetes mellitus (DM) increases active tuberculosis (TB) risk and worsens TB outcomes, jeopardizing control especially in TB-endemic countries with rising DM prevalence rates. We assessed status clinical correlates patients across settings Indonesia, Peru, Romania, South Africa. Methods Age-adjusted was estimated using laboratory glycated hemoglobin (HbA1c) or fasting plasma glucose patients. Detailed standardized sociodemographic, anthropometric, measurements were made....
Tuberculosis (TB) remains a global public health problem. The determination of tuberculosis infection (TBI) using interferon-gamma release assay has now been used widely. We aim to evaluate the positivity rates Standard E TB-Feron enzyme-linked immunosorbent (TB-Feron ELISA) and F fluorescent immunoassay FIA) their agreement with QuantiFERON-TB Gold Plus (QFT-Plus) among TB high-risk populations in Bandung City, Indonesia. conducted cross-sectional study, including people high risk acquiring...
Screening and treatment of latent TB infection (LTBI) disease could reduce diabetes mellitus (DM)-associated TB. We aimed to describe the prevalence LTBI pulmonary among patients with DM in a TB-endemic setting. Patients attending hospital community centres Bandung, Indonesia, underwent screening using interferon gamma release assay (IGRA). was investigated by sputum smear, culture x-ray. contacts from parallel study were age- sex-matched compare prevalence. Of 682 screened, 651 (95.5%)...
Diabetes mellitus is a significant risk factor for tuberculosis (TB). We evaluated the performance of computer-aided detection (CAD4TB) in people living with diabetes (PLWD) Indonesia.PLWD underwent symptom screening and chest X-ray (CXR); sputum was examined those positive symptoms and/or CXR. Digital CXRs were scored using CAD4TB analysed retrospectively clinical microbiological diagnosis as reference. The area under receiver operator curve (AUC) scores determined, an optimal threshold...
Matricellular proteins such as osteopontin (OPN), galectin-9 (Gal-9), and tenascin-C (TN-C) are expressed not only under normal physiological conditions, but also during infection, inflammation tumorigenesis. Plasma concentrations of matricellular were studied to determine their diagnostic value potential markers tuberculosis (TB) activity. It was found that OPN TN-C higher in patients with active TB than healthy controls individuals latent infection. Moreover, LTBI had did controls. Gal-9...
To date, the diagnosis of nontuberculous mycobacteria (NTM) disease primarily relies on clinical symptoms and radiological features. Our objective was to apply a sequence-based analysis method by using partial gene sequencing heat shock protein 65 (hsp65) identify NTM species.A total 32 stored isolates obtained from individuals suspected having pulmonary infection were subjected solid Ogawa culture. Genomic DNA each sample extracted used in conventional polymerase chain reaction (PCR)...
Abstract Objective To describe the characteristics and management of Diabetes mellitus ( DM ) patients from low‐ middle‐income countries LMIC ). Methods We systematically characterised consecutive attending public health services in urban settings Indonesia, Peru, Romania South Africa, collecting data on treatment history, complications, drug treatment, obesity, HbA1c cardiovascular risk profile; assessing gaps against relevant national guidelines. Results Patients (median 59 years, 62.9%...
Diabetes mellitus (DM) is common among tuberculosis (TB) patients and often undiagnosed or poorly controlled. We compared point of care (POC) with laboratory glycated haemoglobin (HbA1c) testing newly diagnosed TB to assess POC test accuracy, safety acceptability in settings which immediate access DM services may be difficult.We measured accredited HbA1c (using high-performance liquid chromatography) 1942 aged 18 years recruited from Peru, Romania, Indonesia South Africa. calculated overall...
Setting: A community health clinic catchment area in the eastern part of Bandung City, Indonesia. Objective: To evaluate feasibility two different screening interventions using workers (CHWs) detecting tuberculosis (TB) cases. Design: This was a study 1) house-to-house TB symptom five randomly selected 'neighbourhoods' area, and 2) household contacts index patients their neighbouring households. Acceptability assessed through focus group discussions with key stakeholders. Results: Of 5100...
Data regarding the incidence of tuberculosis (TB) among people living with diabetes (PLWD) in TB-endemic settings are scarce. We examined TB PLWD Indonesia who had previously been screened for latent infection (LTBI) and disease.PLWD (≥18 y age) an urban setting were a mean 3.4 after they active LTBI. on subsequent diagnosis collected by interview chest X-ray, sputum smear Mycobacterium culture. rates stratified baseline LTBI status, as determined QuantiFERON interferon-gamma release assay...
Diabetes mellitus (DM) patients are three times more likely to develop tuberculosis (TB) than the general population. Active TB screening in people with DM is part of a bidirectional approach. The aim this study was conduct pragmatic active among four countries inform policy.DM were recruited Indonesia (n=809), Peru (n=600), Romania (n=603) and South Africa (n=51). cases diagnosed using an algorithm including clinical symptoms chest X-ray. Presumptive examined sputum smear culture.A total...
BACKGROUND: The implementation of tuberculosis preventive treatment (TPT) is challenging especially in resource-limited settings. As part a Phase 3 trial on TPT, we described our experience with the use rifampicin for 4 months (4R) and isoniazid 9 (9H) Indonesia.METHODS: In 2011-2017, children adults latent TB infection were randomised to either 4R or 9H followed until 16 after randomisation 28 adults. primary outcome was completion rate. Secondary outcomes Grade 3-5 adverse events (AEs),...
Introduction: We aim to describe the performance of combined IgM and IgG point-of-care antibody test (POC-Ab) (Wondfo®) compared real-time reverse transcriptase (rRT-PCR) (Allplex™ 2019-nCoV Assay) in detecting coronavirus disease 2019 (COVID-19).
 Methodology: POC-Ab with rRT-PCR results among patients a tertiary hospital from January March 2020 Bandung, Indonesia. selected presumptive COVID-19 positive consecutively 20 negative were randomly same group as controls. described...
Background Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on households. However, in most high settings, considerable Mycobacterium (Mtb) transmission occurs outside A better understanding of dynamics an urban setting will be crucial for Control Program scaling up towards elimination a more targeted way. Therefore, study aims measure prevalence and incidence household contacts neighbourhoods vicinity known cases assess...
BACKGROUND: Diabetes mellitus (DM) is common among patients with TB. We assessed DM characteristics and long-term needs of DM-TB after completing TB treatment. METHODS: Newly diagnosed were recruited for screening in a randomised clinical trial evaluating simple algorithm to improve glycaemic control during characteristics, lifestyle medication compared before treatment 6 months later. Risk cardiovascular disease (CVD), albuminuria neuropathy RESULTS: Of 218 TB-DM identified, 170 (78%)...
Immune system dysregulation in people with diabetes mellitus (DM) increases the risk of acquiring severe infection. We compared clinical characteristics and laboratory parameters coronavirus disease 2019 (COVID-19) patients without DM estimated effect on mortality among COVID-19 patients. A retrospective cohort study collecting patients' demographic, characteristics, treatment outcomes from medical records was conducted a hospital Bandung City March to December 2020. Univariable...
Adult presumptive tuberculosis (TB) patients ( n = 1690) were screened for TB using a questionnaire, chest X-ray (CXR) and sputum microscopy acid-fast bacilli (AFB); <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> culture was performed 74% of the Xpert ® MTB/RIF done 17.2%. Among recruited, 943 (55.8%) diagnosed with TB, whom 870 (92.3%) bacteriologically confirmed 73 (7.7%) clinically on basis CXR. Using CXR prior to or testing reduces...
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Background The increasing prevalence of diabetes mellitus (DM) requires that patients have greater access to care, which is yet lacking in many low- and middle-income countries the quality varies between health care facilities. We compare characteristics, complications, risk profile receiving primary tertiary level facilities Bandung, Indonesia. MethodsAdult DM were recruited from 25 community centres (CHCs) outpatient clinic at one referral hospital. Key data collected compared national...