A5054176213- Galectins and Cancer Biology
- Bone and Dental Protein Studies
- Tuberculosis Research and Epidemiology
- Viral Infections and Vectors
- T-cell and Retrovirus Studies
- Mosquito-borne diseases and control
- Leptospirosis research and findings
- Mycobacterium research and diagnosis
- Amoebic Infections and Treatments
- Disaster Response and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Research and Treatments
- Oral microbiology and periodontitis research
- Vector-Borne Animal Diseases
- Immunodeficiency and Autoimmune Disorders
- Biomarkers in Disease Mechanisms
- Alkaline Phosphatase Research Studies
- Muscle Physiology and Disorders
- Diagnosis and treatment of tuberculosis
- COVID-19 Clinical Research Studies
- Invertebrate Immune Response Mechanisms
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- Glycosylation and Glycoproteins Research
- Viral Infections and Outbreaks Research
Tohoku University
2010-2024
Inner Mongolia International Mongolian Hospital
2018-2024
Kibi International University
2017-2023
University of Milan
2018
University of Pennsylvania
2018
National Research Institute of Fire and Disaster
2016
National Disaster Medical Center
2012
Along with large-scale loss of life, infrastructural damage, and material losses, health issues have become a crucially important problem after natural disasters. Survivors must confront the threat risks, especially infectious diseases, as result limited supplies, services, facilities. Limited knowledge about risks following disasters, in addition to lack awareness, contributes occurrence diseases that are fundamentally preventable. This study was conducted review eight major disasters...
SUMMARY Dengue fever (DF) and leptospirosis are serious public problems in tropical regions, especially Manila, the Philippines. In attempting to understand causes of DF seasonality, meteorological factors have been suspected, but quantitative correlation between seasonality has not fully investigated. this study, we investigated temporal patterns reported numbers laboratory-confirmed cases both with conditions (temperature, relative humidity, rainfall) Manila. We used time-series analysis...
Dengue virus (DENV) infection remains a major public health burden worldwide. Soluble mediators may play critical role in the pathogenesis of acute DENV infection. Galectin-9 (Gal-9) is soluble β-galactoside-binding lectin, with multiple immunoregulatory and inflammatory properties. To investigate plasma Gal-9 levels as biomarker for We enrolled 65 infected patients during 2010 epidemic Philippines measured their cytokine/chemokine levels, genotypes, copy number recovery phases illness....
In human immunodeficiency virus (HIV) infection, not only HIV itself but also systemic immune activation plays a role in the disease progression to acquired deficiency syndrome (AIDS). The may be present even during highly active antiretroviral therapy (HAART). An increased expression of osteopontin, proinflammatory cytokine, HAART was reported lymph nodes infected individuals. Osteopontin is known involved pathogenesis various HAART-induced diseases. Here, we measured osteopontin and other...
Elevated matricellular proteins (MCPs), including osteopontin (OPN) and galectin-9 (Gal-9), were observed in the plasma of patients with Manila-type tuberculosis (TB) previously. Here, we quantified OPN, Gal-9, soluble CD44 (sCD44) by enzyme-linked immunosorbent assay (ELISA), another 29 cytokines Luminex 36 pulmonary TB, six subjects latent (LTBI), 19 healthy controls (HCs) from Japan for a better understanding roles MCPs TB. All TB showed positive results immunospot assays (ELISPOTs)....
Galectin-9 (Gal-9) is a β-galactoside-binding lectin that interacts with sugar moieties on glycoproteins and glycolipids of cells pathogens. Gal-9 known as an immune modulator induces cell death via interaction T immunoglobulin mucin domain-3 (Tim3), co-inhibitory receptor, it inhibits production several pro-inflammatory cytokines (TNF, IL-6 IL-1α) enhances IL-10. To understand the pathology malaria, in plasma was measured. Plasma samples clinical parameters were obtained from 50 acute...
Acute HIV-1 infection is often diagnosed as infectious mononucleosis and the symptoms resolve spontaneously after varying periods of time. After through mucosa, characteristic clinical laboratory markers acute appear in each patient a complicated virus-host interaction. To understand host responses, we measured two unique proinflammatory cytokines, galectin-9 (Gal-9) osteopontin (OPN). A β-galactoside-binding mammalian lectin, Gal-9, reduces pro-inflammatory type-1 helper T (Th1) cells Th17...
Tuberculosis (TB) is the second most common cause of death from infectious diseases and results in high socioeconomic losses to many countries. Proper diagnosis first step TB eradication. To develop a rapid, simple, accurate diagnostic test characterize prevalence Mycobacterium tuberculosis (MTB) genotypes immune profiles patients, total 37 patients 30 healthy control (HC) Metro Manila were enrolled. Loop-mediated isothermal amplification (LAMP) reliably detected MTB infection. genotype was...
Damage-associated molecular patterns (DAMPs) are endogenous cellular molecules released to the extracellular environment in response stress conditions such as virus infection. Galectins β-galactoside-binding proteins that widely expressed cells and tissues of immune system, localized cell cytoplasm, have roles inflammatory responses against Elevated levels galectin-9 (Gal-9) natural human infections been documented numerous reports. To investigate effect dengue (DENV) infection on expression...
Matricellular proteins such as osteopontin (OPN), galectin-9 (Gal-9), and tenascin-C (TN-C) are expressed not only under normal physiological conditions, but also during infection, inflammation tumorigenesis. Plasma concentrations of matricellular were studied to determine their diagnostic value potential markers tuberculosis (TB) activity. It was found that OPN TN-C higher in patients with active TB than healthy controls individuals latent infection. Moreover, LTBI had did controls. Gal-9...
Adult T-cell leukemia (ATL) is a CD4(+) neoplasm with poor prognosis. A previous study has shown that there strong correlation between the secreted matricellular protein osteopontin (OPN) level and disease severity in ATL patients. Here, we investigated role of OPN pathogenesis possible application anti-OPN monoclonal antibody (mAb) for immunotherapy NOD/Shi-scid,IL-2Rg (null) (NOG) mice.Subcutaneous inoculation cell lines into NOG mice increased plasma OPN, which significantly correlated...
Acquired immunodeficiency syndrome (AIDS) complicated with tuberculosis (TB) is a global public issue. Due to the paucity of bacteria in AIDS/TB, blood-based biomarkers that reflect disease severity are desired. Plasma levels matricellular proteins, such as osteopontin (OPN) and galectin-9 (Gal-9), known be elevated AIDS TB. Therefore, full-length (FL)-Gal9 FL-OPN, their truncated forms (Tr-Gal9, Ud-OPN), 38 cytokines/chemokines were measured plasma 24 (other than TB), 49 TB, 33 AIDS/TB...
Galectin-9 (Gal-9) is known to contribute antiviral responses in coronavirus disease 2019 (COVID-19). Increased circulating Gal-9 COVID-19 associated with severity. In a while, the linker-peptide of susceptible proteolysis that can cause change or loss activity. Here, we measured plasma levels N-cleaved-Gal9, which Gal9 carbohydrate-recognition domain at N-terminus (NCRD) attached truncated linker peptide differs length depending on type proteases, COVID-19. We also investigated time course...
: Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine blood samples 112 patients leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) other kidney-related biomarkers were measured to understand the pathological diagnostic roles OPN Gal-9 in leptospirosis. Plasma levels full-length (FL)-OPN (pFL-OPN) (p < 0.0001), pFL-Gal-9(p 0.0001) thrombin-cleaved 0.01) significantly higher leptospirosis than...
The protease-cleaved osteopontin (OPN) was proposed to enhance the migration of memory T cells granulomas in tuberculosis. Various forms OPN were identified human monocytic THP-1 stimulated by phorbol 12-myristate 13-acetate (PMA). Antibodies O-17, 10A16 and 34E3, which recognize N-terminus, C-half, thrombin-cleaved site OPN, respectively, all detected distinct bands on Western blots following PMA stimulation. Bands corresponding 18 30 kD antibodies 34E3 10A16, indicating that cleavage...
Psoriasis is a chronic, immune-mediated disorder that mainly affects the skin, with an estimated global prevalence of 2-3%. Galectin-9 (Gal-9) β-galactoside-binding lectin capable promoting or suppressing progression infectious and diseases. Here, we determined if expression Gal-9 observed in psoriasis. levels were measured plasma psoriasis (n = 62) healthy control (HC) 31) using enzyme-linked immunosorbent assay. In addition, skin samples from seven patients screened for RNA transcriptomes...