A5085043331- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Biosensors and Analytical Detection
- Dengue and Mosquito Control Research
- Malaria Research and Control
- Retinal Diseases and Treatments
- Bacteriophages and microbial interactions
- Diverse Scientific Research Studies
- Public Health and Nutrition
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Prevention and Impact
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Bee Products Chemical Analysis
- Cancer, Hypoxia, and Metabolism
- Medicinal Plant Research
- Retinal Development and Disorders
- 3D Printing in Biomedical Research
- Healthcare and Venom Research
- Retinal and Macular Surgery
- Phytochemicals and Medicinal Plants
- SARS-CoV-2 and COVID-19 Research
- Natural product bioactivities and synthesis
- Monoclonal and Polyclonal Antibodies Research
Padjadjaran University
2018-2024
University of Indonesia
2023
Molecular Partners (Switzerland)
2012-2018
Universität Trier
2004-2012
The next-generation ophthalmic anti-VEGF therapeutics must aim at being superior to the currently available agents with regard potency and improved drug delivery, while still stable safe use elevated concentrations. We show here generation of a set highly potent VEGF-A antagonistic DARPins (designed ankyrin repeat proteins) delivering these properties. single-digit picomolar affinity human were generated using ribosome display selections. Specific binding was confirmed by ELISA endothelial...
MP0250 is a multi-domain drug candidate currently being tested in clinical trials for the treatment of cancer. It comprises one anti-vascular endothelial growth factor-A (VEGF-A), anti-hepatocyte factor (HGF), and two anti-human serum albumin (HSA) DARPin® domains within single polypeptide chain. While there first validation single-domain candidate, little known about candidates comprising multiple domains. Here, we show that can be expressed at 15 g/L soluble form E. coli high cell-density...
Background: The B16F10 cell line is a frequently used in melanin content assays. However, reports on models using are limited, particularly as the robust model Indonesian cosmetics industry. We found measuring microplate spectrophotometry to be challenging, so this research was conducted develop method μDrop spectrophotometry.Materials and methods: In vitro study, melanoma cultured Roswell Park Memorial Institute (RPMI) medium containing 5% fetal bovine serum (FBS). cells were categorized...
Abstract Dengue Hemorrhagic Fever (DHF) is a major mosquito-borne viral disease. Studies have reported strong correlation between weather, the abundance of Aedes aegypti, vector DHF virus, and dengue incidence. However, this conclusion has been based on general climate pattern wide regions. In general, however, human population, level infrastructure, land-use change in rural urban areas often produce localized patterns that may influence interaction climate, abundance, Thoroughly...
The brain-derived neurotrophic factor (BDNF) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology pathogenesis psychotic disorders, with particular emphasis on dysfunctions hippocampus. aim present study was replicate extend prior findings BDNF val66met genotype effects hippocampal volume N-acetyl aspartate (NAA) levels. Hundred fifty-eight caucasians (66 schizophrenic, 45 bipolar, 47 healthy subjects; 105 subjects underwent MRI 103 MRS...
Working memory deficits are found in different psychiatric populations and most pronounced schizophrenia. There is preliminary evidence from pharmacological studies that the verbal visuospatial subcomponents of working subject to differential neurotransmitter modulation. Here, we investigated impact well-known polymorphisms dopamine transporter gene (SLC6A3, DAT) catechol-O-methyl-transferase (COMT) as well serotonin (SLC6A4, 5-HTT) on these specific a mixed sample patients healthy...
Abstract A single‐chain variable fragment (scFv) is an antibody composed of VH and VL linked by a hydrophilic linker that can be designed according to the shape target molecule synthesized in prokaryotic or eukaryotic cells via biotechnology engineering. This study developed electrochemical immunosensor detects RBD SARS‐CoV‐2 using screen‐printed carbon electrode modified with gold nanoparticles, scFv as bioreceptor. Electrochemical impedance spectroscopy was employed measure specific...
Introduction: Many patients with breast cancer fail to respond conventional chemotherapeutic agents; these agents are also associated numerous adverse events and toxicities. These concerns have led the ongoing search for natural ingredients antitumor effects. As such, aim of this study was explore anti-cancer properties an ethanolic extract propolis (EEP), a product derived from stingless bee, Tetragonula laeviceps. Methods: Bioactive components EEP were identified by gas chromatography–mass...
Purpose: Physalis angulata Linn.(Ciplukan) is a plant widely used in traditional medicine subtropical and tropical regions.Most studies focus on its antioxidant anti-inflammatory activity.Many also reported therapeutic potential for treating cancer, malaria, hepatitis, rheumatism, liver problems, tumors, but few have anti-fibrosis activity.Here, we aimed to investigate the of P. as an that may be correlated with action.Methods: In our study, treated 3T3-L1 TGF-β-induced cells ethanol extract...
DTNBP1 is one of the most established susceptibility genes for schizophrenia, and hippocampal volume reduction major neuropathological findings in this severe disorder. Consistent with these findings, encoded protein dysbindin-1 has been shown to be diminished glutamatergic neurons schizophrenic patients. The aim study was investigate effects two single nucleotide polymorphisms on grey matter volumes human subjects using voxel-based morphometry. Seventy-two were included genotyped respect...
// Ulrike Fiedler 1 , Savira Ekawardhani Andreas Cornelius Pat Gilboy 1, 2 Talitha R. Bakker 3 Ignacio Dolado 4 Michael T. Stumpp and Keith M. Dawson Molecular Partners AG, Schlieren, Switzerland Horizon Pharma, Dublin, Ireland Amgen (Europe) GmbH, Zug, Roche, Basel, Correspondence to: Dawson, email: info@molecularpartners.com Keywords: VEGF, HGF, serum albumin, DARPin ® patient-derived xenograft Received: July 13, 2017 Accepted: September 21, Published: October 11, ABSTRACT Background: The...
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WHO declared the outbreak of COVID-19, caused by SARS-CoV-2, a pandemic in March 2020. More than 223 million cases and approximately 4.6 deaths have been confirmed. Early diagnosis immediate treatment became priority during this pandemic. However, COVID-19 diagnostic testing resources are limited, especially early Apart from being tests using reverse transcription polymerase chain reaction (RT-PCR) encountered storage, transportation, safety issues. These problems mainly experienced...
Introduction: We aim to describe the performance of combined IgM and IgG point-of-care antibody test (POC-Ab) (Wondfo®) compared real-time reverse transcriptase (rRT-PCR) (Allplex™ 2019-nCoV Assay) in detecting coronavirus disease 2019 (COVID-19).
 Methodology: POC-Ab with rRT-PCR results among patients a tertiary hospital from January March 2020 Bandung, Indonesia. selected presumptive COVID-19 positive consecutively 20 negative were randomly same group as controls. described...
Hyperglycemia, a primary symptom in diabetes mellitus, is associated with difficulties wound healing and regeneration. This condition due to the length of inflammatory phase free radicals. Furthermore, there evidence that molecular pathogenesis involved impaired diabetics. As an animal model, zebrafish have many shared orthologous genes human are protein regulation Little known about natural drugs may be used treat complications diabetes. Propolis, however, consist various organic compounds...
Antifibrotic candidates of Selenium nanoparticles and selenium in the experimental modelAziza B. Shalby, Mohamed Diaa Abd El-Maksoud, Ahmed E. Abdel Moneim, Hanaa H.