A5037243339- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Frailty in Older Adults
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Intensive Care Unit Cognitive Disorders
- Retinal and Optic Conditions
- Dementia and Cognitive Impairment Research
- Innovations in Medical Education
- Optical Coherence Tomography Applications
- Acute Ischemic Stroke Management
- Cardiac Fibrosis and Remodeling
- Cardiac, Anesthesia and Surgical Outcomes
- Vestibular and auditory disorders
- Anesthesia and Neurotoxicity Research
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Visual perception and processing mechanisms
- Sympathectomy and Hyperhidrosis Treatments
- Mitochondrial Function and Pathology
Klinikum rechts der Isar
2024-2025
Technical University of Munich
2024-2025
Gansu Provincial Hospital
2023-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Gansu University of Traditional Chinese Medicine
2023-2024
Kunming Medical University
2024
China Southern Power Grid (China)
2024
Johns Hopkins University
2014-2023
Johns Hopkins Medicine
2011-2023
To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) prevalent frailty.Cross-sectional study.Two population-based studies, the Women's Health Aging Studies (WHAS) I II, Baltimore, Maryland.Five hundred fifty-eight women aged 65 to 101 from WHAS 548 70 79 merged II cohorts.Frailty was determined using validated screening criteria. WBC counts IL-6 levels were measured standard laboratory methods. Odds ratios (ORs) for frailty evaluated across tertiles of...
The objective of this study was to measure the biomechanical response human posterior sclera in vitro and estimate effects age glaucoma.Scleral specimens from 22 donors with no history glaucoma 11 a were excised 3 mm equator affixed an inflation chamber. Optic nerve cross-sections graded determine presence axon loss. time-dependent measured series pressure-controlled load-unload tests 30 Hg creep 15 Hg. Circumferential meridional strains computed digital image correlation displacements,...
Objectives To determine the degree to which hyperglycemia predicts development of frailty and lower extremity mobility limitations. Design Secondary data analysis longitudinal collected in a prospective cohort study. Setting B altimore, M aryland. Participants Three hundred twenty‐nine women from W omen's H ealth A ging S tudy II aged 70 79 at baseline who had all variables needed for analysis. Measurements Glycosylated hemoglobin ( b 1c) baseline, categorized as less than 5.5%, 5.5% 5.9%,...
Background Delirium is common after cardiac surgery and has been associated with morbidity, mortality, cognitive decline. However, there are conflicting reports on the magnitude, trajectory, domains of change that might be affected. The authors hypothesized patients delirium would experience greater decline at 1 month yr compared those without delirium. Methods Patients who underwent coronary artery bypass and/or valve or aortic root cardiopulmonary were eligible for this cohort study. was...
<h3>Importance</h3> Delirium occurs in up to 52% of patients after cardiac surgery and may result from changes cerebral perfusion. Using intraoperative autoregulation monitoring individualize optimize perfusion be a useful strategy reduce the incidence delirium surgery. <h3>Objective</h3> To determine whether targeting mean arterial pressure during cardiopulmonary bypass (CPB) using reduces compared with usual care. <h3>Design, Setting, Participants</h3> This randomized clinical trial nested...
To study sequential changes in retinal ganglion cell (RGC) morphology mice after optic nerve crush and induction of experimental glaucoma.Nerve or glaucoma was induced that selectively express yellow fluorescent protein (YFP) RGCs. Mice were euthanized 1, 4, 9 days 3, 6 weeks by bead injection. All YFP-RGCs identified whole mounts. Then confocal images randomly selected RGCs quantified for somal fluorescence brightness, soma size, neurite outgrowth, dendritic complexity (Sholl analysis).By...
Optical coherence tomography (OCT) is a high speed, resolution and non-invasive imaging modality that enables the capturing of 3D structure retina. The fast automatic analysis volume OCT data crucial taking into account increased amount patient-specific data. In this work, we have developed an algorithm, OCTRIMA (OCT Retinal IMage Analysis 3D), could segment in macular region accurately. proposed method implemented using shortest-path based graph search, which detects retinal boundaries by...
OBJECTIVES: To assess whether less physiological complexity underlying regulation of heart rate dynamics, as indicated by lower approximate entropy for (ApEn HR ), is associated with frailty. For supporting validity, relationships between frailty and traditional linear indices variability (HRV) were also assessed. DESIGN: Cross‐sectional. SETTING: Women's Health Aging Study I, a community‐based observational study, 1992 to 1995. PARTICIPANTS: Subset 389 community‐dwelling women aged years...
To determine whether hyperglycemia is related to prevalent frailty status in older women.
Objectives To examine the relationship between fruit and vegetable intake, physical activity, all‐cause mortality in older women. Design Six Cox proportional hazards models examined independent additive relationships carotenoids, mortality. Additional tested whether activity carotenoids were conjointly related to Models adjusted for age, education, race ethnicity. Setting B altimore, M aryland. Participants Seven hundred thirteen women aged 70 79 participating W omen's H ealth A ging S...
In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid β-oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic reticulum Ca2+α ATPase (SERCA) expression downregulated and mitochondrial function reduced HF, perhaps partly due a substantially supply for excitation-contraction coupling resulting lower rate. We investigated whether Astragaloside IV can activate peroxisome proliferator-activated receptor alpha (PPARα) stimulate...
Abstract Background Older adults with visual impairments are at increased risk of negative health outcomes. Here, we investigate the association between impairment and frailty. Methods Cross-sectional longitudinal relationships (distance acuity) frailty (frailty phenotype criteria) were examined using data from National Health Nutrition Examination Survey (NHANES, 1999–2002, ≥60 years) Women’s Aging Studies (WHAS III). Imbalance potential confounders, particularly age, was addressed...
Glutamate/N-methyl-d-aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this reflects activation of COX-2 by S-nitrosylation after selective binding neuronal nitric oxide synthase (nNOS) to COX-2. nNOS, via its PDZ domain, binds with the generated NO S-nitrosylating and activating enzyme. Selective disruption nNOS-COX-2 prevents NMDA neurotoxicity.
Frailty is a geriatric syndrome thought to identify the most vulnerable older adults, and morbidity mortality has been reported be higher for frail patients after cardiac surgery compared nonfrail patients. However, cognitive consequences of frailty have not well described. In this study, we examined hypothesis that baseline would associated with postoperative delirium change at 1 12 months surgery.This study was nested in 2 trials, each which conducted by same research team identical...
Abstract Background To evaluate the discordance in frailty classification between index (FI) and physical phenotype (PFP) identify factors discriminating those with discordant from each other for whom assessments agree. Methods A prospective observational study of older adults aged 65 selected Medicare eligibility lists four U.S. communities (n = 5,362). The PFP was measured by Cardiovascular Health Study PFP. Participants meeting three or more five criteria were deemed frail. FI calculated...