A5066975476- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Infectious Aortic and Vascular Conditions
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Tracheal and airway disorders
- Cardiac Arrest and Resuscitation
- Cardiac tumors and thrombi
- Hip and Femur Fractures
- Intensive Care Unit Cognitive Disorders
- Frailty in Older Adults
- Trauma Management and Diagnosis
- Cardiovascular Health and Disease Prevention
- Cardiac Fibrosis and Remodeling
- Renal and Vascular Pathologies
- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
Jichi Medical University Saitama Medical Center
2016-2025
Jichi Medical University
2016-2025
Hakodate Central General Hospital
2024
Hokkaido University Hospital
2021-2023
Kure Medical Center
2023
National Hospital Organization
2023
Saitama Prefecture
2021
American Society of Anesthesiologists
2018
Jichi Medical University Hospital
2018
Saitama Medical University
2002-2017
Alternatively activated (also known as M2) macrophages are involved in the repair of various types organs. However, contribution M2 to cardiac after myocardial infarction (MI) remains be fully characterized. Here, we identified CD206+F4/80+CD11b+ M2-like murine heart and demonstrated that this cell population predominantly increases infarct area exhibits strengthened reparative abilities MI. We evaluated mice lacking kinase TRIB1 (Trib1-/-), which exhibit a selective depletion Compared with...
Background Delirium is common after cardiac surgery and has been associated with morbidity, mortality, cognitive decline. However, there are conflicting reports on the magnitude, trajectory, domains of change that might be affected. The authors hypothesized patients delirium would experience greater decline at 1 month yr compared those without delirium. Methods Patients who underwent coronary artery bypass and/or valve or aortic root cardiopulmonary were eligible for this cohort study. was...
<h3>Importance</h3> Delirium occurs in up to 52% of patients after cardiac surgery and may result from changes cerebral perfusion. Using intraoperative autoregulation monitoring individualize optimize perfusion be a useful strategy reduce the incidence delirium surgery. <h3>Objective</h3> To determine whether targeting mean arterial pressure during cardiopulmonary bypass (CPB) using reduces compared with usual care. <h3>Design, Setting, Participants</h3> This randomized clinical trial nested...
ObjectiveWe investigated the long-term outcomes of repair for acute type A aortic dissection on basis false lumen status and assessed treatment modalities enlarged downstream aorta.MethodsBetween January 1990 March 2013, 534 patients underwent surgery dissection. In-hospital mortality was 9.3% (50/534), follow-up 98% (472/484). Of 472 hospital survivors, 451 (96%) contrast-enhanced computed tomography within 1 month surgery. Risk-adjusted survival distal events were in these patients....
Appropriate fibrotic tissue formation after myocardial infarction (MI) is crucial to the maintenance of heart's structure. M2-like macrophages play a vital role in post-MI fibrosis by activating cardiac fibroblasts. Because mechanism which regulated not fully understood, we investigated, vitro and vivo, cellular molecular mechanisms formation, especially those related regulation senescence apoptosis. CD206+ F4/80+ CD11b+ collected from mouse hearts on day 7 showed increased expression...
The mechanisms underlying aortic dissection remain to be fully elucidated. We aimed identify key molecules driving through gene expression profiling achieved by microarray analysis and subsequent in vitro experiments using human endothelial cells (HAECs) vascular smooth muscle (AoSMCs). Total RNA, including microRNA (miRNA), was isolated from the intima-media layer of dissected ascending aorta obtained intraoperatively acute type A (ATAAD) patients without familial thoracic disease (n = 8)...
Frailty is a geriatric syndrome thought to identify the most vulnerable older adults, and morbidity mortality has been reported be higher for frail patients after cardiac surgery compared nonfrail patients. However, cognitive consequences of frailty have not well described. In this study, we examined hypothesis that baseline would associated with postoperative delirium change at 1 12 months surgery.This study was nested in 2 trials, each which conducted by same research team identical...
We investigated the influence of false lumen (FL) status on systemic inflammatory response triggered by acute aortic dissection (AAD) using cytokine profiling. The study included 44 patients with AAD. Patients were divided between those a thrombosed FL (Group T, n = 21) and non-thrombosed P, 23). On-admission serum concentrations 29 cytokines compared unmatched propensity-score matched (n 10 pairs) groups control group (non-ruptured thoracic aneurysm, Group C, 20). Unmatched analysis showed...
Ascorbic acid is a strong antioxidant that prevents postoperative delirium by inhibiting reactive oxygen species production. This pilot study was designed to investigate the prevalence of among older patients undergoing cardiovascular surgery, who received perioperative ascorbic administration, estimate an appropriate sample size for further randomized controlled trials. single-arm prospective interventional enrolled aged > 70 years scheduled undergo elective surgery using cardiopulmonary...
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared females. The role androgens play during aneurysm development in males remains unknown. We hypothesized that potentiate transforming growth factor beta induced Erk (extracellular-signal-regulated kinase)/Smad activation, contributing to progression males. Methods Results Aortic diameters Fbn1C1039G/+ littermate wild-type controls were measured at ages 6, 8, 12, 16 weeks. treated (1)...