A5039063528- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Connective tissue disorders research
- Prostate Cancer Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Prostate Cancer Treatment and Research
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Infectious Aortic and Vascular Conditions
- Advanced Radiotherapy Techniques
- Tracheal and airway disorders
- Trauma Management and Diagnosis
- Bladder and Urothelial Cancer Treatments
- Hip and Femur Fractures
- Cardiac Arrest and Resuscitation
- Cell Adhesion Molecules Research
- Aortic Thrombus and Embolism
- Intensive Care Unit Cognitive Disorders
- Vascular anomalies and interventions
- Mechanical Circulatory Support Devices
- Radiomics and Machine Learning in Medical Imaging
- Pericarditis and Cardiac Tamponade
- Cardiac Health and Mental Health
- Orthopaedic implants and arthroplasty
Nihonkai General Hospital
2019-2024
Tokyo Medical Center
2013-2024
National Hospital Organization
2014-2024
Stanford University
2020-2023
Yamagata University Hospital
2020
Yamagata University
1990-2018
Iwaki Kyoritsu General Hospital
2015
Yamagata Prefectural Central Hospital
2015
Objective: To delineate temporal and spatial dynamics of vascular smooth muscle cell (SMC) transcriptomic changes during aortic aneurysm development in Marfan syndrome (MFS). Approach Results: We performed single-cell RNA sequencing to study root/ascending tissue from Fbn1 C1041G/ + (MFS) mice healthy controls, identifying all types. A distinct cluster transcriptomically modulated SMCs (modSMCs) was identified adult mouse only. Comparison with atherosclerotic data (ApoE −/− mice) revealed...
With the use of epicardial mapping, we investigated electrical alternans ST segment during acute myocardial ischemia and studied difference in between dogs with resultant ventricular fibrillation those without it. During 7-minute occlusion left anterior descending coronary artery below its first diagonal branch, 60 unipolar electrograms were recorded simultaneously at 1-minute intervals by a computerized mapping system. was found eight observed. The amplitude (difference elevation two...
The role of increased smooth muscle cell (SMC) integrin αv signaling in Marfan syndrome (MFS) aortic aneurysm remains unclear. Herein, we examine the mechanism and potential efficacy blockade as a therapeutic strategy to reduce progression MFS.
Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field (SHF) and neural crest. Disparate responses to disease-causing Fbn1 variants by these lineages are proposed promote focal aortic aneurysm formation in Marfan syndrome (MFS), but lineage-stratified SMC analysis vivo is lacking. Methods: We generated SHF lineage-traced MFS mice performed integrated multiomic (single-cell RNA assay for transposase-accessible chromatin sequencing) stratified embryological...
Background Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared females. The role androgens play during aneurysm development in males remains unknown. We hypothesized that potentiate transforming growth factor beta induced Erk (extracellular-signal-regulated kinase)/Smad activation, contributing to progression males. Methods Results Aortic diameters Fbn1C1039G/+ littermate wild-type controls were measured at ages 6, 8, 12, 16 weeks. treated (1)...
The diagnosis of small lung nodules has increased in recent years; limited resection and minimally invasive surgery are highly desirable patients with these lesions. While wedge may be curative for nodules, the technique is sometimes difficult to perform when tumour nodule near pulmonary hilum. In such situations, either anatomical segmentectomy or subsegmentectomy can obtain an adequate surgical margin; port-access thoracoscopic preferred type surgery. Three-dimensional (3D) computed...
Limited aortic root repair for acute type A dissection is associated with greater risk of proximal reoperations compared to full replacement. Surgical outcomes patients undergoing reoperative replacement after previous are unknown. This study seeks determine these further inform the debate surrounding optimal upfront management in dissection. Retrospective record review all who underwent a operation at tertiary academic referral center from 2004–2020 was performed. Among 57 cases repair, 35...
Smooth muscle cell (SMC) phenotypic reprogramming toward a mixed synthetic-proteolytic state is central feature of aortic root aneurysm in Marfan syndrome (MFS). Previous work identified
Preemptive thoracic endovascular aortic repair (TEVAR) is an advanced treatment that has possibility to improve late outcomes in patients with subacute type B dissection. However, it may not be the of choice for elderly uncomplicated dissection because their inherent frailty and increased risk periprocedural complications. Data were collected between July 2004 October 2017 Yamagata university hospital February 2016 May 2018 Nihonkai General hospital. A total 152 medically treated enrolled...
Objective Intra-aortic balloon pump (IABP) is one of the most commonly used mechanical circulatory assist devices for high-risk patients undergoing cardiac surgery. In an effort to validate previously reported clinical outcomes, we describe preoperative characteristics and outcomes who underwent prophylactic IABP in coronary artery bypass grafting (CABG). Design A prospective observational study Methods From 2005 2017, 471 either isolated or combined CABG at our institution. Of those, 393...
Objectives: Uncomplicated type B aortic dissection is generally treated with medical management including antihypertensive therapy. The purpose of this study to investigate risk factors associated the enlargement in medically patients.
Salvage radical prostatectomy is one of treatments after radiation therapy to patients with prostate cancer. To date, no case the salvage robotic assisted (RARP) following heavy ion radiotherapy (HIRT) has been published. We report on a 70-year-old man history HIRT for cancer in 2011. For 3 years after. HIRT, his serum PSA levels were permissible range. However, increased. had diagnosis localized HIRT. carried out RARP. Until 10 months RARP, level was not detectable.
To analyze outcomes following whole-gland salvage treatments applied to patients with pathology-proven, locally recurrent prostate cancer primary definitive radiotherapy.Eighteen consecutive who received at our institution were retrospectively reviewed. All underwent transperineal template-guided mapping biopsy (TTMB) using the standard iodine-125 (125I) brachytherapy (BT) setup. Twelve 125I BT, and six robot-assisted laparoscopic prostatectomy (RARP). Prostate-specific antigen (PSA) failure...
Abstract Objective In patients with stable hemodynamic status after an acute coronary syndrome (ACS), artery bypass grafting (CABG) preoperative investigations can provide outcomes comparable to those of emergency surgery. However, no established guidelines exist regarding the preparation period before We report results use inpatient cardiac rehabilitation program followed by CABG ACS improve post-operative and prognosis discharge. Methods From 2005 2017, 471 underwent either isolated or...
Salvage radical prostatectomy is a postradiation treatment for patients with localized prostate cancer. In 2016, Ozu
【背景】Stanford A型急性大動脈解離における基部への解離進展は高頻度に認められる．A型急性解離における基部解離の進展範囲と冠動脈口との関連をもとに，基部修復法，手術成績，遠隔予後および治療方針の妥当性を検討した．【対象】1997年7月から2011年5月の期間に当科で施行した急性A型解離に対する手術80例を対象とした．【結果】手術死亡5例，病院死亡4例であった．Sino-tubular junctionをこえた解離の中枢側進展を72例（90%）に認めた．冠動脈周囲へ解離が及んだ症例は28例であった．左右両方の冠動脈へ波及した解離は11例であり，Valsalva洞の破裂と高度の大動脈弁閉鎖不全（AR）に対し，Bentall手術3例，David手術1例，大動脈弁置換術（AVR）1例を施行した．右冠動脈への解離進展は17例，このうち大動脈弁輪拡張症，ARに対する基部置換術（Freestyle弁）2例，partial remodeling 1例，断端形成＋CABG...
Introduction: Vascular smooth muscle cells (SMC) undergo phenotype modulation (silenced contractile genes and activated proteolytic/synthetic genes) in Marfan syndrome (MFS) aortic aneurysm. Aortic root SMCs develop from the second heart field (SHF) proximally neural crest (NC) distally. We hypothesize that both developmental lineage hemodynamic factors dictate SMC vulnerability to change, promoting focal Methods/Results: roots adult MFS littermate control mice (n=4 each sex) with a knockin...