A5024374494- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Trauma Management and Diagnosis
- Airway Management and Intubation Techniques
- Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Cardiac tumors and thrombi
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Sarcoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Metastasis and carcinoma case studies
- Cancer-related gene regulation
- Myasthenia Gravis and Thymoma
- Gastric Cancer Management and Outcomes
- Pneumothorax, Barotrauma, Emphysema
Mie Chuo Medical Center
2024
Yamato Municipal Hospital
2024
Yamagata University
2014-2023
Society of Thoracic Surgeons
2022
Yamagata University Hospital
2010-2020
Fudan University Shanghai Cancer Center
2018
Shanghai Pulmonary Hospital
2018
Tongji University
2018
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018
Chongqing Medical University
2018
Aberrant methylation of promoter CpG islands is known to be a major inactivation mechanism tumor suppressor and tumor‐related genes. To determine the clinicopathological significance gene in non‐small cell lung cancer (NSCLC), we examined status APC, DAP‐kinase, E‐cadherin, GSTP1, hMLH1, p16, RASSF1A RUNX3 genes 75 NSCLCs corresponding non‐neoplastic tissues by methylation‐specific PCR (MSP). The frequencies were: 37% (28 75) 48% (36 for APC , 28% (21 13% (10 DAP‐kinase 29% (22 15% (11...
The incidence of small-sized pulmonary adenocarcinomas with ground-glass opacity (GGO) has recently increased, excellent postoperative prognosis. limited resection such cancers been deemed to be acceptable based on retrospective studies. We conducted a prospective multi-institutional study evaluating the validity for adenocarcinoma GGO.The inclusion criteria were 25-80 years age, no prior treatment, maximum tumour diameter 8-20 mm, GGO ratio ≥ 80%, clinical T1N0M0, lower...
Although wedge resection can be curative for small lung tumours, tumour marking is sometimes required of non-palpable or visually undetectable nodules as a method identification tumours. Tumour fails and occasionally causes serious complications. We have performed many thoracoscopic segmentectomies using 3D computed tomography simulation tumours without any markings. The aim this study was to investigate whether segmentectomy planned with could precisely remove tumours.Between January 2012...
In lung resection, thoracoscopy has been mainly used for wedge resection and lobectomy. There have very few reports on pulmonary segmentectomy, because of its complex nature. The present report evaluates the safety efficacy thoracoscopic segmentectomy treatment benign diseases or small carcinomas.The study involved 30 patients who underwent without a minithoracotomy from September 2004 to March 2008. median age was 69 years (range, 16-81 years). Four 5-20 mm ports were used. vessels ligated,...
Abstract Background Saliva is often used as a biomarker for the diagnosis of some oral and systematic diseases, owing to non‐invasive attribute fluid. In this study, we aimed identify salivary biomarkers distinguishing lung cancer (LC) from benign lesion (BLL). Materials Methods Unstimulated saliva samples were collected 41 patients with LC 21 BLL. Salivary metabolites comprehensively analyzed using capillary electrophoresis mass spectrometry. To differentiate between LCs BLLs,...
Objectives: Recently, diffusion-weighted MR imaging (DWI) for the whole body has become available clinical use, as been previously used central nervous system. Favorable results have reported using this system to differentiate between benign and malignant lesions in some organs, correlate with degree of cell differentiation lung cancer. The purpose study was assess role DWI predicting tumor invasiveness non-small cancers (NSCLC), especially stage IA patients. Methods: From January 2006...
Pulmonary segmentectomy is generally acknowledged to be more technically complex than lobectomy. Three-dimensional computed tomography (3D CT) angiography useful for understanding the pulmonary arterial and venous branching, as well planning surgery secure adequate surgical margins. Comprehension of intersegmental intrasegmental veins makes parenchymal dissection easier. To visualize segmental border, creation an inflation-deflation line by using a method inflating affected segment has...
Background: GSKJ4, an H3K27 demethylase inhibitor, reportedly exhibits antitumor activity against specific cancers harboring genetic alterations in genes encoding chromatin modulators. However, its potential as anticancer agent human not associated with such alterations, including non-small cell lung cancer (NSCLC), remains unknown. Materials and Methods: The effect of GSKJ4 on the growth three NSCLC lines normal fibroblasts was investigated using WST-8, dye exclusion, colony formation...
The diagnosis of small lung nodules has increased in recent years; limited resection and minimally invasive surgery are highly desirable patients with these lesions. While wedge may be curative for nodules, the technique is sometimes difficult to perform when tumour nodule near pulmonary hilum. In such situations, either anatomical segmentectomy or subsegmentectomy can obtain an adequate surgical margin; port-access thoracoscopic preferred type surgery. Three-dimensional (3D) computed...
Epidemiological studies have demonstrated a causal link between tobacco smoking and lung cancer. We investigated the association inactivation of p16 gene in 51 non-small cell cancers (NSCLCs). Aberrations were studied by PCR single-strand conformation polymorphism analysis, followed direct sequencing, microsatellite methylation-specific PCR, immunohistochemistry. Mutations detected 3.9% (2/51) tumors; tumors carrying mutations from smokers. The incidences loss heterozygosity, homozygous...
Intersegmental demarcation line on the surface of visceral pleura could not be found at thoracoscopic findings. The resected segments inflation (RSI) method has been reported as a useful technique for visualizing intersegmental during segmentectomy. Thoracoscopic anatomic segmentectomy is performed follows: firstly, pulmonary vein and artery segment planned resection are dissected from hilum in order to isolate segmental bronchus located behind artery. Secondly, monofilament non-absorbable...
With the recent increase in detection of small-sized lung nodules because widespread use computed tomography (CT), limited resection and minimally invasive surgery are preferred by patients with these lesions. In particular, that show ground-glass opacity during high-resolution CT has increased. Although lobectomy lymph node dissection were standard procedures used for treating cancer, wedge segmentectomy have become acceptable cancers showing opacity. These widely performed, especially they...