A5064826227- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Cancer Immunotherapy and Biomarkers
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Temporomandibular Joint Disorders
- Tracheal and airway disorders
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Liver Disease and Transplantation
- RNA and protein synthesis mechanisms
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Soft tissue tumor case studies
Tohoku University
1966-2025
Miyagi Prefectural Hospital Organization
2015-2024
Tochigi Cancer Center
2021-2023
Educational Research Institute
2021
Sendai Medical Center
2016
University of Hyogo
2005
Hyogo Prefectural Nishinomiya Hospital
1995
University of Colorado Health
1993
University of Colorado Denver
1993
Jackson Memorial Hospital
1993
Cancer-associated fibroblasts (CAFs) exert various effects upon biological behaviours of cancer. In this study, we examined the correlation CAFs with intra-tumoural immune system in lung adenocarcinoma microenvironment. We studied 27 and 113 cases tentatively as Cohorts 1 2, respectively. The patients Cohort received epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for recurrent adenocarcinoma. α-smooth muscle actin (α-SMA), a surrogate marker CAFs, was by...
The incidence of small-sized pulmonary adenocarcinomas with ground-glass opacity (GGO) has recently increased, excellent postoperative prognosis. limited resection such cancers been deemed to be acceptable based on retrospective studies. We conducted a prospective multi-institutional study evaluating the validity for adenocarcinoma GGO.The inclusion criteria were 25-80 years age, no prior treatment, maximum tumour diameter 8-20 mm, GGO ratio ≥ 80%, clinical T1N0M0, lower...
Lung cancer remains the leading cause of death. Treatment with immune checkpoint inhibitor (ICI) alone or combination chemotherapy served as first-line therapy in non-small cell lung (NSCLC). However, only 20-50% NSCLC patients respond to ICI. Necroptosis, an inflammatory form death plays important role regulation tumor microenvironment which may affect prognosis and ICI response but its clinical significance has remained largely unknown. Therefore, we aimed analyze correlation between key...
Abstract The interaction between a shock wave and an object causes impulsive force on the that lasts for very short time order of milliseconds. This study proposes measurements using anodized aluminum pressure-sensitive paint (AA-PSP), which is optical pressure measurement technique. response AA-PSP microseconds, indicating potential fast drag by integrating distribution surface. In this study, at first, fabricated measured determined to be $$3.3~\upmu \hbox {s}$$ <mml:math...
Lung cancer is the most common cause of mortality, however, efficient methods to culture, expand and transform lung epithelial (LE) cells have not been established. In present study, an ex vivo method was applied recapitulate carcinogenesis using mouse LE cells. A Matrigel-assisted three-dimensional culture used isolate selectively from lungs. Purified were passaged expanded for at least 2 3 months while maintaining epidermal growth factor-dependence. also easily transformed by genetic...
Periostin is a matricellular protein that secreted by fibroblasts and interacts with various cell-surface integrin molecules. Although periostin known to support tumor development in human malignancies, little about its effect on lung-cancer progression. We here demonstrate negative prognostic factor increases proliferation through ERK signaling non-small cell lung carcinoma. classified 189 clinical specimens from patients according high or low expression, found better prognosis for rather...
Immunotherapy is considered one of the most important therapeutic strategies for patients with lung adenocarcinoma after development epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance. However, useful predictors immunotherapy these has not been examined well, although status tumor immune microenvironment (TIME), including programmed death-ligand 1 expression and lymphocyte infiltration, generally known to provide predictive markers efficacy immunotherapy. This...
A 53-year-old man was admitted to our hospital with a recurrence of spontaneous pneumothorax. He had no history other diseases including chronic lung diseases. month prior this admission, he first pneumothorax and treated 4 days intercostal drainage. CT scan showed bulla, but revealed multiple small polygonal lesions consistent fibrotic mainly in the right lower lobe (figure 1). We performed thoracotomy found that air leakage arose from torn visceral pleura which been pierced by...
BACKGROUND:Nivolumab is an anti-PD-1 immune checkpoint inhibitor that was recently developed for cancer immunotherapy. In the clinical trials of nivolumab, its adverse effects were reported to be less likely than those conventional anti-cancer agents; however, after practical distribution, it has come known nivolumab induces various immune-related events. CASE REPORT:A 58-year-old male with a recurrence lung adenocarcinoma treated nivolumab. Only four days initial administration patient...
An extremely rare case of mixed squamous cell and glandular papilloma the lung is reported. The correlation between radiological pathological features as well clinical pitfall in making a diagnosis discussed.An asymptomatic 68-year-old female with cigarette smoking habit presented small nodule her peripheral lung. A wedge resection was performed though it failed on-site which instead obtained following scrutiny. postsurgical course excellent no recurrence disease.A ground glass gradually...
Osimertinib is the latest generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor used for patients with EGFR-mutated non-small cell lung cancer (NSCLC). We aimed to explore novel mechanisms of osimertinib by particularly focusing on EGFR-independent effects, which have not been well characterized. explored effects proliferation using NSCLC lines, an antibody array analysis, and association between action ephrin B4 (EphB4). also studied clinicopathological significance...
Abstract Background Understanding the status of intratumoural immune microenvironment is necessary to ensure efficacy immune-checkpoint (IC) blockade therapy. Cortisol plays pivotal roles in glucocorticoid interactions system. We examined correlation between intratumourally synthesised cortisol through 11β hydroxysteroid dehydrogenase (HSD) 1 and non-small-cell lung carcinoma (NSCLC). Methods correlated 11βHSD1 immunoreactivity 125 cases NSCLC with amount cells present, IC therapy 18...
Abstract Background Exposure to environmental carcinogens, such as through smoking, is a major factor in the carcinogenesis of non‐small cell lung cancer (NSCLC). However, genetic factors may also contribute. Methods To identify candidate tumor suppressor genes for NSCLC, we included 23 patients (10 related pairs and 3 individuals) with NSCLC who had other NSCLC‐affected first‐degree relatives local hospital. Exome analyses both germline somatic (NSCLC specimens) DNA were performed 17 cases....
A broncho-pulmonary artery fistula is one of the most fatal complications lung cancer surgery. This article discusses case a patient who died massive hemoptysis after left upper lobectomy. There were no previous signs broncho-pleural except for an obstinate dry cough and slightly elevated serum C-reactive protein levels An autopsy revealed that had formed between bronchial stump pulmonary artery, leading to prolonged inflammation ultimately fistula. The lobectomy right sleeve resection are...
Various proteins are highly expressed in cancer (e.g., epidermal growth factor receptor); however, the majority also normal cells, although they may differ expression intensity. Recently, we reported that CD271 (nerve receptor), a glycosylated protein, increases malignant behavior of cancer, particularly stemlike phenotypes squamous cell carcinoma (SCC). is SCC and epithelial basal cells. Glycosylation alterations generally occur cells; therefore, attempted to establish cancer-specific...