A5006258604- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Epigenetics and DNA Methylation
- Neonatal Health and Biochemistry
- Trace Elements in Health
- Immune Response and Inflammation
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Heme Oxygenase-1 and Carbon Monoxide
Chulalongkorn University
2020-2024
Karolinska Institutet
2023
Abstract Necroptosis, a regulated form of necrosis, has emerged as novel therapeutic strategy that could enhance cancer immunotherapy. However, its role in tumorigenesis is still debated because recent studies have reported both anti- and pro-tumoral effects. Here, we aimed to systematically evaluate the associations between tumor necroptosis (mixed lineage kinase domain-like protein, MLKL; phosphorylated MLKL, pMLKL; receptor-interacting protein 1–receptor-interacting 3, RIPK1–RIPK3...
Abstract Cell death is a fundamental biological process, and its fine-tuned regulation required for life. However, the complexity of regulated cell often reduced to matter live-dead discrimination. Here, we provide perspective on programmed or death, focusing apoptosis, pyroptosis, necroptosis, ferroptosis (the latter three modalities are examples necrosis). We also touch other, recently described manifestations (pathological) including cuproptosis. Furthermore, address how engineered...
Ferroptosis, a form of iron-dependent, lipid peroxidation-driven cell death, has been extensively investigated in recent years, and several studies have suggested that the ferroptosis-inducing properties iron-containing nanomaterials could be harnessed for cancer treatment. Here we evaluated potential cytotoxicity iron oxide nanoparticles, with without cobalt functionalization (Fe2O3 Fe2O3@Co-PEG), using an established, ferroptosis-sensitive fibrosarcoma line (HT1080) normal fibroblast (BJ)....
Cholangiocarcinoma (CCA) is an aggressive cancer associated with a very poor prognosis and low survival rates, primarily due to late-stage diagnosis response rates conventional chemotherapy. Therefore, there urgent need identify effective therapeutic strategies that can improve patient outcomes. Flavonoids, such as quercetin kaempferol, are naturally occurring compounds have attracted significant attention for their potential in therapy by targeting multiple genes. In this study, we employed...
Lung cancer remains the leading cause of death. Treatment with immune checkpoint inhibitor (ICI) alone or combination chemotherapy served as first-line therapy in non-small cell lung (NSCLC). However, only 20-50% NSCLC patients respond to ICI. Necroptosis, an inflammatory form death plays important role regulation tumor microenvironment which may affect prognosis and ICI response but its clinical significance has remained largely unknown. Therefore, we aimed analyze correlation between key...
Cholangiocarcinoma (CCA), a malignant tumor originating in the biliary tract, is well known to be associated with adverse clinical outcomes and high mortality rates due lack of effective therapy. Evasion apoptosis considered key contributor therapeutic success chemotherapy resistance CCA, highlighting need for novel strategies. In this study, we demonstrated that induction necroptosis, regulated form necrosis, could potentially serve as approach CCA patients. The RNA sequencing data Cancer...
Abstract Background Toll-like receptor 3 (TLR3) ligand which activates TLR3 signaling induces both cancer cell death and anti-tumor immunity. However, can also harbor pro-tumorigenic consequences. Therefore, we examined the status of in cholangiocarcinoma (CCA) cases to better understand explore potential therapeutic target CCA. Methods The expression receptor-interacting protein kinase 1 (RIPK1) primary CCA tissues was assayed by Immunohistochemical staining their associations with...