A5025790741- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Advanced Battery Technologies Research
- Tuberous Sclerosis Complex Research
- Vascular Anomalies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Electric and Hybrid Vehicle Technologies
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Pulmonary Hypertension Research and Treatments
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Vascular Tumors and Angiosarcomas
- Medical Imaging and Pathology Studies
- Fuel Cells and Related Materials
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Histiocytic Disorders and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
- Lung Cancer Research Studies
- Arsenic contamination and mitigation
- Cancer-related molecular mechanisms research
- Mine drainage and remediation techniques
Tohoku University
2014-2025
Tohoku University Hospital
2021-2022
National Institute for Environmental Studies
2022
University of Yamanashi Hospital
2019
Niigata University
2012
Sendai Red Cross Hospital
2007
Kyoto University
2001
Johns Hopkins University
1997
Johns Hopkins Medicine
1997
Tokyo Medical and Dental University
1996
Cancer-associated fibroblasts (CAFs) exert various effects upon biological behaviours of cancer. In this study, we examined the correlation CAFs with intra-tumoural immune system in lung adenocarcinoma microenvironment. We studied 27 and 113 cases tentatively as Cohorts 1 2, respectively. The patients Cohort received epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for recurrent adenocarcinoma. α-smooth muscle actin (α-SMA), a surrogate marker CAFs, was by...
ABSTRACT This article reports on the complete genome of Pseudomonas sp. strain Stari2, which was shown to have ability degrade carbon tetrachloride (CCl 4 ) in aerobic conditions. A single circular sequence 6,310,573 bp, a GC content 60.3%, and 5,680 coding sequences were obtained. In silico analysis revealed an average nucleotide identity 94.06% its closest species.
Members of a subclass hairy/Enhancer split [E(spl)] homologs, called hesr genes, are structurally related to another hairy/E(spl) Hes which play an important role in neural development. To characterize the roles genes development, we used retina as model system. In situ hybridization analysis indicated that all expressed developing retina, but only hesr2 expression is associated spatially with gliogenesis. Each member was then misexpressed retrovirus retinal explant cultures prepared from...
Lung cancer remains the leading cause of death. Treatment with immune checkpoint inhibitor (ICI) alone or combination chemotherapy served as first-line therapy in non-small cell lung (NSCLC). However, only 20-50% NSCLC patients respond to ICI. Necroptosis, an inflammatory form death plays important role regulation tumor microenvironment which may affect prognosis and ICI response but its clinical significance has remained largely unknown. Therefore, we aimed analyze correlation between key...
Background Whereas multiple basic helix‐loop‐helix (bHLH) genes are expressed in the developing nervous system, they account for differentiation of only subsets neurones, suggesting that there may be as‐yet unidentified bHLH genes. Results We have isolated a novel gene, designated Math6 , distant mammalian homologue Drosophila proneural gene atonal . Structural analysis demonstrated coding region is divided into three exons, whereas other homologues present single exon, indicating genomic...
Purinergic receptors play an important role in regulating Cl- secretion epithelial cells. To explore further the of these intestine, we utilized human intestinal cell line, Caco-2, grown on permeable membrane supports and assayed for by measuring short-circuit current (Isc). Stimulation Isc extracellular nucleotides could be detected day 4 increased 10 postseeding. The magnitude stimulation at microM cells was UTP > ATP UDP 2-methylthioadenosine 5'-triphosphate (2-MeS-ATP) = ADP apical...
Epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR-TKI) resistance is one of the most important problems in lung cancer therapy. Lung adenocarcinoma with EGFR-TKI was reported to have higher abilities invasion and migration than cancers sensitive EGFR-TKI, but function matrix metalloproteinases (MMPs) has not been explored EGFR-TKI–resistant adenocarcinoma. This study aims clarify significance MMP-1 From results vitro studies assays using EGFR-TKI–sensitive –resistant cell...
2011年3月11日の東北地方太平洋沖地震により,岩手・宮城・福島県沿岸部を中心に甚大な津波被害が発生し,震災域は津波堆積物により広く被覆された.ヒ素のリスクを評価するために,岩手県久慈市から福島県南相馬市にかけて137個の津波堆積物を採取し,全堆積物化学組成の分析,水および海水溶出試験を行った.また,水溶出液に対して3 kDa以下,3 kDa−0.2 μm,0.2 μm−0.45 μm,および0.45 μm以上の4つに分液し,ヒ素の化学形態について評価した.45試料においてヒ素の水溶出量は土壌環境基準値(10 μg/l)を超過した.特に,気仙沼市大谷地域においては,水溶出量が土壌環境基準値の39倍と極めて高く,ここに分布する金鉱山の影響を強く受けていると考えられる.溶出液中のヒ素の約70%は3 kDa以下であり,溶出液中のヒ素は微細なコロイドおよび溶存態として含まれていることを示している.
Prolongation of the activated partial thromboplastin time (APTT) may be caused by a factor deficiency, inhibitor coagulation factors, lupus anticoagulant, liver dysfunction, or anticoagulants such as unfractionated heparin and direct oral anticoagulants. Waveform analyses APTT assay results from automated analyzers have been used for assessing very low levels (<1 IU/dl) VIII (FVIII) IX (FIX) in-vivo clotting function in patients with various types hemophilia A [1–3]. It was reported that...
We have identified a gene, rig (rat insulinoma gene), that is activated in chemically induced rat insulinomas but not normal pancreatic islets or regenerating islets. In the present study, we found gene was BK virus-induced hamster cell line and spontaneously occurring human insulinoma. From cDNA libraries, homologues were isolated, their nucleotide sequences determined. same manner as both contained one open reading frame of 435 nucleotides, differing by 32- 41-base substitutions,...
A 74-year-old woman who exhibited drowsiness was referred to our hospital. Enhanced head magnetic resonance imaging (MRI) revealed multiple ring-enhancing lesions and showing partial mild hemorrhaging. The patient gradually progressed a comatose condition with notable brain deterioration of unknown cause on follow-up MRI. On day nine, the inexplicably died, although herniation suspected. Autopsy histopathology numerous amoebic trophozoites in perivascular spaces within necrotic tissue. Brain...
The exact pathophysiology of HSN remains to be elucidated. Hence, a therapeutic strategy that enables curative treatments for all the various grades patients has yet established. We report our experience performing tonsillectomy combined with steroid therapy 16 pediatric proteinuric Henoch-Schönlein nephritis (HSN) patients. All exhibited hematuria and proteinuria in their first attack mean age onset 7.7 years (range 4.75 - 13.9 years). Nine were diagnosed clinically severe presenting...
PET bottle waste is easy to recycle because it separate, abundant, and competitively priced. Technologies for the treatment of have been evaluated date by using life cycle assessment (LCA), but this does not take into account all aspects that policymakers consider necessary when selecting an acceptable technology. Aspects such as society, economics, policies, technical applicability need be considered along with environment resource consumption complement LCA results waste. These were...
Lysophosphatidic acid (LPA) is a structurally simple, platelet-derived phospholipid, capable of eliciting variety physiological responses. We have demonstrated previously that LPA elicited marked contractile response in rat mesangial cells (Inoue CN, Forster HG, Epstein M. Circ Res 77:888-896, 1995). In the present study, we examined potential this vasoactive substance to induce cell proliferation. Serum-starved quiescent were incubated with either or combination growth factor (PDGF). DNA...
As shown in our previous studies, the intratracheal-administration of STC1 (stanniocalcin-1) ameliorates pulmonary fibrosis by reducing oxidative and endoplasmic reticulum stress through uncoupling respiration a bleomycin-treated mouse model. However, overall effect on metabolism was not examined. Therefore, we first conducted comprehensive metabolomics analysis to screen metabolic changes induced an alveolar epithelial cell line using capillary electrophoresis time-of-flight mass...
Osimertinib is the latest generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor used for patients with EGFR-mutated non-small cell lung cancer (NSCLC). We aimed to explore novel mechanisms of osimertinib by particularly focusing on EGFR-independent effects, which have not been well characterized. explored effects proliferation using NSCLC lines, an antibody array analysis, and association between action ephrin B4 (EphB4). also studied clinicopathological significance...
BACKGROUND: Biomarkers predicting clinical outcomes of treating non-small cell lung cancer (NSCLC) with combination immune checkpoint inhibitors (ICIs) and chemotherapy would be valuable. OBJECTIVE: This study aims to seek predictors ICI/chemotherapy response in NSCLC patients using peripheral blood samples. METHODS: Patients diagnosed advanced between July 2019 May 2021 receiving were included assessed for partial responses (PR), stable disease (SD) or progressive (PD). We measured...
Cancer-associated fibroblasts (CAFs) are a heterogeneous population of with various features in the cancer stroma and have been reported to influence progression through cell-cell interactions types malignancies, including lung adenocarcinoma (LUAD). Dipeptidyl peptidase 4 (DPP4) is transmembrane protein serine protease activity involved tumors, metabolic diseases, autoimmune diseases. In present study, we focused on role DPP4-positive CAFs LUAD. Immunohistochemistry revealed that 38 89 LUAD...
Geochemical analyses (total nitrogen: TN, total organic carbon: TOC, sulfur: TS, and stable sulfur isotope ratio: δ34S) were performed on tsunami deposits by the 2011 off Pacific coast of Tohoku Earthquake obtained from Iwate, Minamisanriku, Kesen-numa, Sendai Bay areas for a 133 samples. Although TOC/TN ratios ranged widely (0.7–90), most samples (more than 80% samples) 10–30, which similar results to those marine surface sediment in area. Low δ34S values (from -29.6‰ -11.3‰) Minami...
Epithelioid angiomyolipoma (EAML) has been known as a potentially malignant tumor which occasionally recur and/or metastasize to other organs, and clinically pathologically recognized distinct entity. However, the mechanisms of recurrence metastasis (recurrence/metastasis) still remained unknown. Here, we report two cases renal EAML associated with recurrence/metastasis, three in kidney or liver without recurrence/metastasis. According previous histological predictive models EAML, primary...