A5003507095- Adipokines, Inflammation, and Metabolic Diseases
- Angiogenesis and VEGF in Cancer
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- NF-κB Signaling Pathways
- Oral microbiology and periodontitis research
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Proteoglycans and glycosaminoglycans research
- Chemokine receptors and signaling
- Mesenchymal stem cell research
- interferon and immune responses
- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Atherosclerosis and Cardiovascular Diseases
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- Neurogenesis and neuroplasticity mechanisms
- Cell Adhesion Molecules Research
- Parathyroid Disorders and Treatments
- Pharmacogenetics and Drug Metabolism
- Biomarkers in Disease Mechanisms
- Protease and Inhibitor Mechanisms
Pusan National University
2013-2024
Pusan National University Dental Hospital
2012-2024
Inje University
2011-2012
Chung-Ang University
2012
Pusan National University Yangsan Hospital
2011
Jeonbuk National University
2007-2010
Catholic University of Korea
2010
Kazan State Medical University
2010
Keimyung University Dongsan Medical Center
2009
Keimyung University
2009
Hypoxia is a well-known signal for angiogenesis, but the recent proposal that hypoxia exists in developing embryonic tissues and it induces vascular development remains to be proven. In present study, we demonstrate presence of normal embryos by means marker, pimonidazole, its associated antibody. Our data clearly show marker immunoreactivity was highly detected neural tubes, heart, intersomitic mesenchyme at an early stage organogenesis, suggesting may exist stages embryo development. We...
ABSTRACT We have isolated the basic helix-loop-helix (bHLH) gene Hes6, a novel member of family mammalian homologues Drosophila hairy and Enhancer split. Hes6 is expressed by both undifferentiated differentiated cells, unlike Hes1, which only former cells. alone does not bind to DNA but suppresses Hes1 from repressing transcription. In addition, inhibiting Mash1-E47 heterodimer thereby enables Mash1 E47 upregulate transcription in presence Hes1. Furthermore, misexpression with retrovirus...
Visfatin has been originally identified as a growth factor for early stage B cells and recently known an adipokine. Here, we report that hypoxia induces the visfatin mRNA protein levels in MCF7 breast cancer cells. We also demonstrate induction of gene is regulated by hypoxia‐inducible factor‐1α (HIF‐1α). Moreover, 5′‐flanking promoter region human contains two functional HIF responsive elements (HREs), activating expression visfatin. Mutation these HREs abrogates activation luciferase...
// Hyun-Joo Park 1 , Su-Ryun Kim Su Seong Hee-Jun Wee 2 Moon-Kyoung Bae 3 Mi Heon Ryu 4 and Soo-Kyung Department of Dental Pharmacology, School Dentistry, Pusan National University, Yangsan, South Korea Biochemistry, College Pharmacy, Seoul Seoul, Oral Physiology, Pathology, Correspondence: Bae, email: Keywords : Visfain; Notch1; NF- κB; breast cancer cells Received May 9, 2014 Accepted June Published 10, Abstract Overexpression Notch1 has been associated with cancer. We recently showed that...
Crocin is a water-soluble carotenoid pigment that primarily used in various cuisines as seasoning and coloring agent, well traditional medicines for the treatment of edema, fever, hepatic disorder. In this study, we demonstrated crocin markedly induces expression heme oxygenase-1 (HO-1) which leads to an anti-inflammatory response. inhibited inducible nitric oxide synthase (iNOS) production via downregulation nuclear factor kappa B activity lipopolysaccharide- (LPS-) stimulated RAW 264.7...
Members of a subclass hairy/Enhancer split [E(spl)] homologs, called hesr genes, are structurally related to another hairy/E(spl) Hes which play an important role in neural development. To characterize the roles genes development, we used retina as model system. In situ hybridization analysis indicated that all expressed developing retina, but only hesr2 expression is associated spatially with gliogenesis. Each member was then misexpressed retrovirus retinal explant cultures prepared from...
Obesity is frequently associated with breast cancer. Such associations are possibly mediated by adipokines. Visfatin, an adipokine, has recently been shown to be related the development and progression of Therefore, down-regulation visfatin may a novel strategy for cancer therapy. Curcumin anticancer activities modulating multiple signaling pathways genes. The purpose this study was investigate whether gene expression affected curcumin in human cells characterize functional role We found...
Background Whereas multiple basic helix‐loop‐helix (bHLH) genes are expressed in the developing nervous system, they account for differentiation of only subsets neurones, suggesting that there may be as‐yet unidentified bHLH genes. Results We have isolated a novel gene, designated Math6 , distant mammalian homologue Drosophila proneural gene atonal . Structural analysis demonstrated coding region is divided into three exons, whereas other homologues present single exon, indicating genomic...
Increased interleukin (IL)-8 plays an important role not only in activation and recruitment of neutrophils but also inducing exaggerated angiogenesis at the inflamed site. In present study, we investigated fact that clotrimazole (CLT) inhibits intestinal inflammation, inhibitory action is mediated through suppression IL-8 expression. trinitrobenzene sulfonic acid (TNBS)-induced rat colitis model, CLT dose-dependently protected from TNBS-induced weight loss, colon ulceration, myeloperoxidase...
Abstract The von Hippel-Lindau protein (pVHL) is a major tumor suppressor and also associated with the inhibition of angiogenesis via HIF-1α ubiquitination proteasomal degradation. To further elucidate biological activity pVHL in angiogenesis, pVHL-interacting proteins were screened using yeast two-hybrid system. We found that mouse homologue long form Drosophila l(2)tid, Tid-1L, directly interacts vitro vivo. Furthermore, Tid-1L protein; enhanced interaction between pVHL, leading to...
AimsOur aims were to determine the role of Notch1 in mediating visfatin-induced angiogenesis and explore potential target genes involved.