A5083698397- Enzyme Catalysis and Immobilization
- Heme Oxygenase-1 and Carbon Monoxide
- Asymmetric Hydrogenation and Catalysis
- Analytical Chemistry and Chromatography
- Autophagy in Disease and Therapy
- Diverse Topics in Contemporary Research
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Angiogenesis and VEGF in Cancer
- Barrier Structure and Function Studies
- Cultural and Historical Studies
- Korean Urban and Social Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Ginseng Biological Effects and Applications
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Eicosanoids and Hypertension Pharmacology
- Chemical Reaction Mechanisms
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Catalytic Alkyne Reactions
- MicroRNA in disease regulation
- Carbohydrate Chemistry and Synthesis
- Educational Systems and Policies
- High Altitude and Hypoxia
Massachusetts General Hospital
2015-2025
Harvard University
2015-2025
Konkuk University
2016-2025
University of Central Florida
1998-2024
CHA Bundang Medical Center
2024
CHA University
2005-2024
Florida College
2022
Gachon University
2018-2020
Korea University
2000-2019
Korea University Medical Center
2016-2019
A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This employs a palladium nanocatalyst as racemization catalyst, commercial lipase (Novozym-435) and ethyl acetate or methoxyacetate acyl donor. Eleven one amino acid amide have efficiently resolved with good yields (85−99%) high enantiomeric excesses (97−99%).
Carbon monoxide (CO) plays a significant role in vascular functions. We here examined the molecular mechanism by which CO regulates HIF-1 (hypoxia-inducible transcription factor-1)-dependent expression of endothelial growth factor (VEGF), is an important angiogenic factor. found that astrocytes stimulated with CORM-2 (CO-releasing molecule) promoted angiogenesis increasing VEGF and secretion. also induced HO-1 (hemeoxygenase-1) increased nuclear HIF-1α protein level, without altering its...
Hypoxia stabilizes hypoxia-inducible factors (HIFs), facilitating adaptation to hypoxic conditions. Appropriate hypoxia is pivotal for neurovascular regeneration and immune cell mobilization. However, in central nervous system (CNS) injury, prolonged severe harms the brain by triggering inflammation, oxidative stress, glial activation, vascular damage, mitochondrial dysfunction, death. Diminished improves cognitive function individuals with CNS injuries. This review discusses current...
Therapeutic drug development for central nervous system injuries, such as traumatic brain injury (TBI), presents significant challenges. TBI results in primary mechanical damage followed by secondary injury, leading to cognitive dysfunction and memory loss. Our recent study demonstrated the potential of carbon monoxide-releasing molecules (CORMs) improve recovery enhancing neurogenesis. However, a comprehensive strategy requires not only neurogenesis but also oligodendrogenesis. In this...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRhodium(I)-Catalyzed Asymmetric Intramolecular Pauson−Khand-Type ReactionNakcheol Jeong, Byung Kee Sung, and Yoon Kyung ChoiView Author Information Department of Chemistry Division Molecular Engineering Korea University, 1-5 ka, Anam-dong, Sungbuk-ku Seoul, 136-701, Cite this: J. Am. Chem. Soc. 2000, 122, 28, 6771–6772Publication Date (Web):June 27, 2000Publication History Received28 February 2000Published online27 June inissue 1 July...
Aminocyclopentadienyl ruthenium complexes, which can be used as room-temperature racemization catalysts with lipases in the dynamic kinetic resolution (DKR) of secondary alcohols, were synthesized from cyclopenta-2,4-dienimines, Ru3(CO)12, and CHCl3: [2,3,4,5-Ph4(η5-C4CNHR)]Ru(CO)2Cl (4: R = i-Pr; 5: n-Pr; 6: t-Bu), [2,5-Me2-3,4-Ph2(η5-C4CNHR)]Ru(CO)2Cl (7: 8: Ph), [2,3,4,5-Ph4(η5-C4CNHAr)]Ru(CO)2Cl (9: Ar p-NO2C6H4; 10: p-ClC6H4; 11: Ph; 12: p-OMeC6H4; 13: p-NMe2C6H4). The tests...
A new procedure for the dynamic kinetic resolution (DKR) of racemic alcohols into single enantiomers is described. This employs surfactant-treated subtilisin as an (S)-selective resolving catalyst and aminocyclopentadienylruthenium complex a racemizing catalyst. The DKR performed best in presence acyl donor such trifluoroethyl butyrate THF at room temperature. Eight simple secondary have been efficiently resolved with high optical purities good yields. subtilisin-based complementary...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTLipase/Palladium-Catalyzed Asymmetric Transformations of Ketoximes to Optically Active AminesYoon Kyung Choi, Mi Jung Kim, Yangsoo Ahn, and Mahn-Joo KimView Author Information National Research Laboratory Chirotechnology, Department Chemistry, Division Molecular Life Sciences, Pohang University Science Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea Cite this: Org. Lett. 2001, 3, 25, 4099–4101Publication Date (Web):November 16,...
Many diseases of the eye such as retinoblastoma, diabetic retinopathy, and retinopathy prematurity are associated with blood–retinal barrier (BRB) dysfunction. Identifying factors that contribute to BRB formation during human development maintenance could provide insights into diseases. Here we show A-kinase anchor protein 12 (AKAP12) induces by increasing angiopoietin-1 decreasing vascular endothelial growth factor (VEGF) levels in astrocytes. We reveal AKAP12 downregulates level...
With a coat for activity: A highly active enzyme was prepared by coating Burkholderia cepacia lipase with an ionic surfactant use in dynamic kinetic resolution (DKR). Important features of this include: the fastest DKR 1-phenylethanol, enantioselective wide range secondary alcohols (RCH(OH)Ar), and switching enantioselectivity depending on shape aliphatic chain (R). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but...
The heme oxygenase-1 (HO-1)/carbon monoxide (CO) pathway induced in astrocytes after ischemic brain injury promotes vascular endothelial growth factor (VEGF) expression to maintain and repair neurovascular function. Although HO-1-derived CO has been shown induce hypoxia-inducible factor-1α (HIF-1α)-dependent VEGF expression, the underlying mechanism independent of HIF-1α remains be elucidated.HO-1 were coexpressed mouse tissues. Experiments with specific siRNAs pharmacological...
Cerebral microvasculature of patients with Alzheimer's disease (AD) exhibits reduced capillary diameter and impaired blood flow. Molecular mechanisms ischemic vessels affecting AD progressions have not been well established yet. In the present study, we found that in vivo triple (PS1M146V, APPswe, tauP301L) transgenic mouse model (3x-Tg AD) brains retinas showed hypoxic expressing hypoxyprobe hypoxia inducible factor-1α (HIF-1α). To mimic vessels, used vitro oxygen-glucose deprivation...
A practical procedure has been developed for the dynamic kinetic resolution of 1,2-diarylethanols. This employs a highly enantioselective lipase from Pseudomonas stutzeri (trade name, TL) as catalyst and ruthenium complex racemization catalyst. Sixteen 1,2-diarylethanols have efficiently resolved to provide their acetyl derivatives with good yields (95-97%) high enantiomeric excesses (96-99%).