A5103042597- Food Quality and Safety Studies
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Probiotics and Fermented Foods
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- GABA and Rice Research
- Angiogenesis and VEGF in Cancer
- Pregnancy and preeclampsia studies
- Viral gastroenteritis research and epidemiology
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Fermentation and Sensory Analysis
- Mycotoxins in Agriculture and Food
- Tea Polyphenols and Effects
- Advanced Glycation End Products research
- Ginger and Zingiberaceae research
- Paraquat toxicity studies and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Reproductive Biology and Fertility
- Autophagy in Disease and Therapy
- Sarcoidosis and Beryllium Toxicity Research
- TGF-β signaling in diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Listeria monocytogenes in Food Safety
World Institute of Kimchi
2015-2024
Yeungnam University
2012-2024
Korea National Institute of Health
2024
Ewha Womans University
2024
Inje University Haeundae Paik Hospital
2024
Hanyang University Seoul Hospital
2019-2023
Chung-Ang University
2019-2023
Kangwon National University
2014-2020
Yeungnam University College
2012-2020
Inha University
2020
Inflammatory cytokines, including tumor necrosis factor-α (TNFα), were elevated in patients with cardiovascular diseases and are also considered as crucial factors the pathogenesis of preeclampsia; however, underlying pathogenic mechanism has not been clearly elucidated. This study provides novel evidence that TNFα leads to endothelial dysfunction associated hypertension vascular remodeling preeclampsia through down-regulation nitric-oxide synthase (eNOS) by NF-κB–dependent biogenesis...
Laminar flow protects from atherosclerosis in endothelium.Laminar induces Nrf2 activation dependent on ERK5 activation, leading to up-regulation of downstream genes Nrf2.ERK5 requires exert cytoprotective effect HUVEC. inhibitor BIX02189 regulates vivo.Identifying as a molecular target for regulating flow-mediating Nrf2-dependent gene expression may have significant therapeutic potential treating atherosclerosis. Atherosclerosis is often observed areas where disturbed formed, whereas...
Heme oxygenase-1-derived carbon monoxide prevents inflammatory vascular disorders. To date, there is no clear evidence that HO-1/CO endothelial dysfunction associated with the downregulation of NO synthesis in human cells stimulated TNF-α. Here, we found CO-releasing compound CORM-2 prevented TNF-α-mediated decreases eNOS expression and NO/cGMP production, without affecting promoter activity, by maintaining functional activity mRNA 3′-untranslated region. By contrast, inhibited MIR155HG...
Korean red ginseng extract (KRGE) enhances astrocytic functions through hypoxia-inducible factor-1α (HIF-1α). Astrocytic Ca 2+ influx L-type channels (LTCCs) facilitates neurovascular communication, while the large-conductance - and voltage-activated K + (BK) channel mediates efflux for vasodilation. However, role of LTCC subunits in KRGE-mediated BKα HIF-1α expression astrocytes remains unclear. This study aimed to investigate effects KRGE on subunits, cytosolic influx, induction human...
Atherosclerosis preferentially involves in prone area of low and disturbed blood flow while steady high levels laminar are relatively protected from atherosclerosis. Disturbed induces endoplasmic reticulum (ER) stress the unfolded protein response (UPR). ER is caused under that disturbs processing folding proteins resulting accumulation misfolded activation UPR. Prolonged or severe UPR leads to activate apoptotic signaling. Recent studies have indicated significantly up-regulated p-ATF6α,...
Abstract Vascular smooth muscle cells (VSMCs) play an important role in maintaining vascular function. Inflammation-mediated VSMC dysfunction leads to atherosclerotic intimal hyperplasia and preeclamptic hypertension; however, the underlying mechanisms are not clearly understood. We analyzed expression levels of microRNA-155 (miR-155) cultured VSMCs, mouse vessels, clinical specimens then assessed its Treatment with tumor necrosis factor-α (TNF-α) elevated miR-155 biogenesis VSMCs vessel...
Extracorporeal removal techniques are effective methods for toxin from the body. To define safety and clinical outcomes of hemoperfusion, we evaluated retrospectively hemoperfusion over a 3-year period in our center. From January 2006 to December 2008, analyzed 803 patients. Mortality, catheter-related bleeding, systemic hypocalcemia, thrombocytopenia were investigated. Medical drugs (n = 54) pesticide toxins 749) represented. Pesticides included herbicides 598), insecticides 130), mixed 4),...
Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron is known prevent the pathogenesis of several human diseases. We assessed beneficial effect degradation products on osteoclastogenesis induced by receptor activator NF-κB ligand (RANKL). Treatment RAW264.7 cells with CORM-2 (a CO donor) bilirubin, but not iron, decreased RANKL-induced osteoclastogenesis, having a more potent anti-osteogenic effect. also inhibited RANKLinduced osteoclastic resorption...
It has been suggested that methylglyoxal (MGO), a glycolytic metabolite, more detrimental effects on endothelial dysfunction than glucose itself. Recent reports showed high and MGO induced endoplasmic reticulum (ER) stress myocyte apoptosis in ischemic heart disease was inhibited by apelin. The goal of the study is to investigate molecular mechanism which induces via regulation ER cells, examine whether apelin-13, cytoprotective polypeptide ligand, protects MGO-induced aortic dysfunction....
Recent studies have indicated that protease-activated receptor-1 (PAR-1) is involved in cytoprotective and anti-inflammatory responses endothelial cells (ECs). However, the role of PAR-1 laminar flow-mediated atheroprotective remains unknown. Herein, we investigated whether regulates mechanotransduction ECs. Confocal analysis showed was internalized into early endosomes response to flow. In addition, flow cytometry cell surface expression reduced by flow, suggesting activated Depletion using...
Idiopathic pulmonary fibrosis (IPF) is a specific form of progressive and chronic interstitial lung disease unknown cause. IPF characterized by excessive deposition extracellular matrix (ECM) destructive pathological remodeling due to epithelial-to-mesenchymal transition (EMT). Eventually, interstitium thickens stiffens breathing becomes difficult. It has been well established that the transforming growth factor-β1 (TGF-β1)/Smad signaling pathway plays critical role in pathogenesis fibrosis....
Abstract Endothelial progenitor cell (EPC) dysfunction impairs vascular function and remodeling in inflammation-associated diseases, including preeclampsia. However, the underlying mechanism of this inflammation-induced remains unclear. In present study, we found increases TNF-α miR-31/155 levels reduced numbers circulating EPCs patients with Patient-derived mononuclear cells (MNCs) cultured autologous serum had decreased endothelial nitric oxide synthase (eNOS) expression, production,...
Zearalenone (ZEN) is a non-steroidal mycotoxin that has various toxicological impacts on mammalian health. Here, we found ZEN significantly affected the production of nitric oxide (NO) and expression endothelial NO synthase (eNOS) bovine aortic cells (BAECs). A promoter analysis using 5′-serially deleted human eNOS revealed proximal region (−135 to +22) was responsible for ZEN-mediated reduction activity. This effect reversed by mutation two specificity protein 1 (Sp1) binding elements in...
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the therapeutic mechanisms effects tetrapeptide Arg-Leu-Tyr-Glu (RLYE), VEGFR2 inhibitor, development permeability choroidal (CNV). In cultured human retinal microvascular cells (HRMECs), treatment with RLYE blocked VEGF-A-induced phosphorylation VEGFR2, Akt, ERK, nitric oxide synthase...