A5083117986- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Cardiac Arrest and Resuscitation
- Barrier Structure and Function Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Sepsis Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Neuroscience and Neuropharmacology Research
- Laser Applications in Dentistry and Medicine
- Neurogenesis and neuroplasticity mechanisms
- Kruppel-like factors research
- Functional Brain Connectivity Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Intensive Care Unit Cognitive Disorders
- Optical Imaging and Spectroscopy Techniques
- Nerve injury and regeneration
- Neonatal Respiratory Health Research
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Springer Nature (Germany)
2023
Wolters Kluwer (Netherlands)
2023
NFL Foundation
2023
Whale Museum
2023
Tufts University
2011-2017
GlaxoSmithKline (United States)
2017
MaineGeneral Medical Center
2008-2015
Society of Critical Care Medicine
2015
Increased risk of neurological and psychiatric conditions after traumatic brain injury (TBI) is well-defined. However, cardiovascular endocrine comorbidity TBI in individuals without these comorbidities associations with post-TBI mortality have received little attention.To assess the incidence cardiovascular, endocrine, neurological, patients mild (mTBI) or moderate to severe (msTBI) analyze between mortality.This prospective longitudinal cohort study used hospital-based patient registry...
Therapeutic drug development for central nervous system injuries, such as traumatic brain injury (TBI), presents significant challenges. TBI results in primary mechanical damage followed by secondary injury, leading to cognitive dysfunction and memory loss. Our recent study demonstrated the potential of carbon monoxide-releasing molecules (CORMs) improve recovery enhancing neurogenesis. However, a comprehensive strategy requires not only neurogenesis but also oligodendrogenesis. In this...
Necroptosis is a newly identified type of programmed necrosis initiated by the activation tumor factor alpha (TNFalpha)/Fas. Necrostatin-1 specific inhibitor necroptosis that reduces ischemic tissue damage in experimental stroke models. We previously reported decreased and improved functional outcome after controlled cortical impact (CCI) mice deficient TNFalpha Fas. Hence, we hypothesized necrostatin-1 would reduce histopathology improve CCI mice. Compared with vehicle-/inactive...
OBJECTIVE: To present a state-of-the-art review of mechanisms secondary injury in the evolution damage after severe traumatic brain infants and children. DATA SOURCES: We reviewed 152 peer-reviewed publications, 15 abstracts proceedings, other material relevant to study biochemical, cellular, molecular injury. Clinical studies children were focus, but reports experimental models immature animals also considered. Results from both clinical adults adult presented for comparison. SYNTHESIS:...
Cytokines may play an important role in the pathophysiology of traumatic brain injury (TBI) children. Interleukin-6 (IL-6) is a proinflammatory cyotkine that plays regenerative processes within central nervous system (CNS), whereas interleukin-10 (IL-10) antiinflammatory cytokine. Both have been measured serum and cerebrospinal fluid (CSF) as index degree inflammation diseases, including sepsis meningitis. We hypothesized both IL-6 IL-10 would be increased CSF children after severe TBI....
Background and Objective Transcranial low-level laser therapy (LLLT) using near-infrared light can efficiently penetrate through the scalp skull could allow non-invasive treatment for traumatic brain injury (TBI). In present study, we compared therapeutic effect 810-nm wavelength in continuous pulsed wave modes a mouse model of TBI. Study Design/Materials Methods TBI was induced by controlled cortical-impact device 4-hours post-TBI 1-group received sham 3-groups single exposure to...
BACKGROUND: Although previous evidence suggests that the cognitive effects of concussions are cumulative, effect time interval between repeat is largely unknown. OBJECTIVE: To determine on function mice. METHODS: We used a weight-drop model concussion to subject anesthetized mice 1, 3, 5, or 10 concussions, each day apart. Additional were subjected 5 at varying intervals: daily, weekly, and monthly. Morris water maze performance was measured 24 hours, 1 month, year after final injury....
Objective Although there is growing awareness of the long‐term cognitive effects repetitive mild traumatic brain injury (rmTBI; eg, sports concussions), whether repeated concussions cause deficits remains controversial. Moreover, depend on increased amyloid β deposition and tau phosphorylation or are worsened by apolipoprotein E4 allele unknown. Here, we use an experimental model rmTBI to address these clinical controversies. Methods A weight drop was used that results in without loss...
Abstract Background and Objectives Traumatic brain injury (TBI) affects millions worldwide is without effective treatment. One area that attracting growing interest the use of transcranial low‐level laser therapy (LLLT) to treat TBI. The fact near‐infrared light can penetrate into would allow non‐invasive treatment be carried out with a low likelihood treatment‐related adverse events. LLLT may TBI by increasing respiration in mitochondria, causing activation transcription factors, reducing...
Necroptosis is a newly described form of regulated necrosis that contributes to neuronal death in experimental models stroke and brain trauma. Although much work has been done elucidating initiating mechanisms, signaling events governing necroptosis remain largely unexplored. Akt known inhibit apoptotic cell death. Mechanistic target rapamycin (mTOR) downstream effector controls protein synthesis. We previously reported dual inhibition mTOR reduced acute improved long term cognitive deficits...
Low-level laser light therapy (LLLT) exerts beneficial effects on motor and histopathological outcomes after experimental traumatic brain injury (TBI), coherent near-infrared has been reported to improve cognitive function in patients with chronic TBI. However, the of LLLT recovery TBI are unknown. We hypothesized that administered controlled cortical impact (CCI) would post-injury Morris water maze (MWM) performance. (800 nm) was applied directly contused parenchyma or transcranially mice...
Traumatic brain injury (TBI) is a major public health issue exacting substantial personal and economic burden globally. With the advent of "big data" approaches to understanding complex systems, there potential greatly accelerate knowledge about mechanisms how detect modify them improve patient outcomes. High quality, well-defined data are critical success bioinformatics platforms, dictionary "common elements" (CDEs), as well "unique has been created for clinical TBI research. There no...
The neuroinflammatory response to traumatic brain injury (TBI) is critical both neurotoxicity and neuroprotection, has been proposed as a potentially modifiable driver of secondary in animal human studies. Attempts broadly target immune activation have unsuccessful improving outcomes, part because the precise cellular molecular mechanisms driving outcome at acute, subacute, chronic time points after TBI remain poorly defined. Microglia play role neuroinflammation their persistent may...
<h3>Importance</h3> Hyperosmolar agents are cornerstone therapies for pediatric severe traumatic brain injury. Guideline recommendations 3% hypertonic saline (HTS) based on limited numbers of patients, and no study to date has supported a recommendation mannitol. <h3>Objectives</h3> To characterize current use hyperosmolar in injury assess whether HTS or mannitol is associated with greater decreases intracranial pressure (ICP) and/or increases cerebral perfusion (CPP). <h3>Design, Setting,...
We studied the role of FGF-2 on regulation neurogenesis and cell loss in granule layer (GCL) hippocampal dentate gyrus after experimental traumatic brain injury (TBI). In both FGF-2–/– FGF-2+/+ mice subjected to controlled cortical impact, number dividing cells labeled with BrdU, injected posttrauma days 6 through 8, increased at 9 TBI, BrdU-positive colabeled neuron-specific nuclear antigen significantly 35 days. However, injured mice, neurons (days 9, 35) were fewer compared mice. There...
To determine interleukin (IL)-8 concentrations in ventricular cerebrospinal fluid from children with severe traumatic brain injury (TBI).Prospective study.University children's hospital.Twenty-seven hospitalized TBI (Glasgow Coma Scale score < or =8), seven culture-positive bacterial meningitis, and twenty-four age-equivalent controls.Placement of an intraventricular catheter continuous drainage fluid.Median [range] IL-8 concentration (0-12 hrs) (4,452.5 [0-20,000] pg/mL) was markedly...
Poly(ADP-ribose) polymerase (PARP), or poly-(ADP-ribose) synthetase, is a nuclear enzyme that consumes NAD when activated by DNA damage. The role of PARP in the pathogenesis traumatic brain injury (TBI) unknown. Using controlled cortical impact (CCI) model TBI and mice deficient PARP, authors studied effect on functional histologic outcome after CCI using two protocols. In protocol 1, naive (n = 7 +/+, n 6 -/-) were evaluated for motor memory acquisition before CCI. Mice then subjected to...
Tumor necrosis factor-alpha (TNFalpha) and Fas are induced after traumatic brain injury (TBI); however, their functional roles incompletely understood. Using controlled cortical impact (CCI) mice deficient in TNFalpha, Fas, or both (TNFalpha/Fas-/-), we hypothesized that TNFalpha receptor mediate secondary TBI a redundant manner. Compared with wild type (WT), TNFalpha/Fas-/- had improved motor performance from 1 to 4 days (P<0.05), spatial memory acquisition at 8 14 decreased lesion size 2 6...