A5058049602- Sulfur Compounds in Biology
- Nitric Oxide and Endothelin Effects
- PARP inhibition in cancer therapy
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Folate and B Vitamins Research
- Immune Response and Inflammation
- Cardiac electrophysiology and arrhythmias
- Adenosine and Purinergic Signaling
- Amino Acid Enzymes and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Electron Spin Resonance Studies
- Calcium signaling and nucleotide metabolism
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Respiratory Support and Mechanisms
- Renin-Angiotensin System Studies
- Toxin Mechanisms and Immunotoxins
- Advanced Glycation End Products research
- Renal function and acid-base balance
University of Fribourg
2018-2025
Magyar Agrár- és Élettudományi Egyetem
2024
The University of Texas Medical Branch at Galveston
2013-2023
University of Debrecen
2018-2023
John von Neumann University
2022
University of Pecs
1995-2020
Shriners Hospitals for Children - Galveston
2009-2019
Bipar
2018
Inimex Pharmaceuticals (Canada)
2012-2017
National and Kapodistrian University of Athens
2016-2017
The recent discovery that hydrogen sulfide (H(2)S) is an endogenously produced gaseous second messenger capable of modulating many physiological processes, much like nitric oxide, prompted us to investigate the potential H(2)S as a cardioprotective agent. In current study, we demonstrate delivery at time reperfusion limits infarct size and preserves left ventricular (LV) function in vivo model myocardial ischemia-reperfusion (MI-R). This observed cytoprotection associated with inhibition...
The goal of the current study was to investigate role exogenous and endogenous hydrogen sulfide (H 2 S) on neovascularization wound healing in vitro vivo. Incubation endothelial cells (ECs) with H S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, capillary morphogenesis Matrigel. Treatment chicken chorioallantoic membranes (CAMS) increased vascular length. Exposure ECs resulted phosphorylation Akt, ERK, p38. K ATP channel blocker glibenclamide or p38...
In this report, we show that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron transport chain activates three major pathways hyperglycemic damage found in aortic endothelial cells inhibiting GAPDH activity. bovine cells, antisense oligonucleotides activated each vascular cultured 5 mM glucose to same extent as induced culturing 30 glucose. Hyperglycemia-induced inhibition was be a consequence poly(ADP-ribosyl)ation poly(ADP-ribose) polymerase (PARP), which DNA...
The physiological functions of hydrogen sulfide (H 2 S) include vasorelaxation, stimulation cellular bioenergetics, and promotion angiogenesis. Analysis human colon cancer biopsies patient-matched normal margin mucosa revealed the selective up-regulation H S-producing enzyme cystathionine-β-synthase (CBS) in cancer, resulting an increased rate S production. Similarly, cancer-derived epithelial cell lines (HCT116, HT-29, LoVo) exhibited CBS production, compared with nonmalignant colonic...
Hydrogen sulfide (H 2 S) is a unique gasotransmitter, with regulatory roles in the cardiovascular, nervous, and immune systems. Some of vascular actions H S (stimulation angiogenesis, relaxation smooth muscle) resemble those nitric oxide (NO). Although it was generally assumed that NO exert their effects via separate pathways, results current study show are mutually required to elicit angiogenesis vasodilatation. Exposure endothelial cells increases intracellular cyclic guanosine...
The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo formation of ONOO- has been demonstrated in shock inflammation. Herein we provide evidence that cytotoxicity cells exposed is mediated by DNA strand breakage the subsequent activation repair enzyme poly(ADP ribose) synthetase (PARS). Exposure (100 microM 1 mM) inhibited mitochondrial respiration cultured J774 macrophages rat aortic smooth muscle cells. loss...
Abstract Adenosine released into the extracellular space by immunologic and nonimmunologic stimuli has been shown to regulate various immune functions. In this study we report that i.p. pretreatment of mice with CGS-21680 HCl (CGS), a selective agonist A2 adenosine receptors, at 0.2 2 mg/kg caused an augmentation plasma IL-10 levels induced injection LPS, but decreased LPS-induced TNF-alpha. 2-Chloro-N6-cyclopentyladenosine (CCPA), A1 0.5 diminished TNF-alpha concentrations, enhanced only...
Interleukin 12 (IL-12) is a crucial cytokine in the regulation of T helper 1 vs. 2 immune responses. In present study, we investigated effect endogenous purine nucleoside adenosine on production IL-12. mouse macrophages, suppressed IL-12 production. Although order potency receptor agonists suggested involvement A2a receptors, data obtained with receptor-deficient mice showed that suppression and even TNF-α only partly mediated by ligation. Studies antagonists or uptake blocker dipyridamole...
Enhanced formation of nitric oxide (NO) by both the constitutive and inducible isoforms NO synthase (NOS) has been implicated in pathophysiology a variety diseases, including circulatory shock. Non-isoform-selective inhibition formation, however, may lead to side effects inhibiting isoform NOS and, thus, various physiological actions NO. S-Methylisothiourea sulfate (SMT) is at least 10- 30-fold more potent as an inhibitor (iNOS) immunostimulated cultured macrophages (EC50, 6 microM) vascular...
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...