A5002633561- Receptor Mechanisms and Signaling
- Hypothalamic control of reproductive hormones
- Pharmacological Receptor Mechanisms and Effects
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- Ovarian function and disorders
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Phosphodiesterase function and regulation
- Growth Hormone and Insulin-like Growth Factors
- Amino Acid Enzymes and Metabolism
- Plant Reproductive Biology
- Regulation of Appetite and Obesity
- Biomedical Text Mining and Ontologies
- Steroid Chemistry and Biochemistry
- Plant-based Medicinal Research
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Scientific Computing and Data Management
- Monoclonal and Polyclonal Antibodies Research
- Wnt/β-catenin signaling in development and cancer
- Protein Kinase Regulation and GTPase Signaling
University of Edinburgh
2012-2023
Discovery Centre
2020
International Union of Basic and Clinical Pharmacology
2020
Edinburgh College
2012-2019
The Queen's Medical Research Institute
2005-2013
Université de Montpellier
2013
Centre National de la Recherche Scientifique
2013
University of Michigan
2013
Servier (France)
2013
University of Nottingham
2013
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets ligands from selected papers in pharmacology drug discovery since 2003. This resource continues be developed conjunction with the International Union of Basic Clinical Pharmacology (IUPHAR) British Pharmacological Society (BPS). As previously described, our unique model content selection quality control is based on 96 target-class...
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs their targets in the human genome. Developed by International Union of Basic Clinical Pharmacology (IUPHAR) British Pharmacological Society (BPS), this resource, its earlier incarnation as IUPHAR-DB, is described our 2014 publication. This update incorporates changes over intervening seven database releases. unique model...
The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional pathophysiological data on the targets approved experimental drugs. Created under auspices IUPHAR BPS, portal provides concise, peer-reviewed overviews key properties wide range established potential drug targets, with in-depth information for...
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although represents approximately 400 pages, material presented is substantially reduced compared information website. It a permanent, citable, point-in-time record that will...
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although represents approximately 400 pages, material presented is substantially reduced compared information website. It a permanent, citable, point-in-time record that will...
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties over 2000 human drug targets with their pharmacology, plus links an open access knowledgebase and ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full . G protein‐coupled receptors are one seven major pharmacological into is divided, others being receptors,...
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties over 1750 human drug targets with their pharmacology, plus links an open access knowledgebase and ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13354/full . G protein‐coupled receptors are one eight major pharmacological into is divided, others being: receptors, ligand‐gated ion...
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties over 1750 human drug targets with their pharmacology, plus links an open access knowledgebase and ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13348/full . G protein‐coupled receptors are one eight major pharmacological into is divided, others being: ligand‐gated ion channels,...
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties over 2000 human drug targets with their pharmacology, plus links an open access knowledgebase and ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full . Enzymes are one seven major pharmacological into is divided, others being G protein‐coupled receptors, ligand‐gated...
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
We identified a gene in the ovine hypothalamus encoding for RFamide-related peptide-3 (RFRP-3), and tested hypothesis that this system produces hypophysiotropic hormone inhibits function of pituitary gonadotropes. The RFRP-3 encodes peptide appears identical to human homolog. Using an antiserum raised against RFRP-3, cells were localized dorsomedial hypothalamic nucleus/paraventricular nucleus brain shown project neurosecretory zone median eminence, predicating role regulation anterior gland...
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews key properties nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although represents approximately 400 pages, material presented substantially reduced compared information...
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although represents approximately 400 pages, material presented is substantially reduced compared information website. It a permanent, citable, point-in-time record that will...
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties over 2000 human drug targets with their pharmacology, plus links an open access knowledgebase and ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full . Ion channels are one seven major pharmacological into is divided, others being G protein‐coupled receptors,...
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties over 1750 human drug targets with their pharmacology, plus links an open access knowledgebase and ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13355/full. G protein-coupled receptors are one eight major pharmacological into is divided, others being: receptors, ligand-gated ion...
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...