A5016689951- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Nicotinic Acetylcholine Receptors Study
- Adenosine and Purinergic Signaling
- Diabetes Treatment and Management
- Protein Kinase Regulation and GTPase Signaling
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Electroconvulsive Therapy Studies
- Chemical Synthesis and Analysis
- Schizophrenia research and treatment
- Treatment of Major Depression
- Cancer Treatment and Pharmacology
- Parkinson's Disease and Spinal Disorders
- Neurological and metabolic disorders
- Diet and metabolism studies
- Epilepsy research and treatment
- Lipid Membrane Structure and Behavior
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Drug-Induced Adverse Reactions
Monash University
2016-2025
Australian Regenerative Medicine Institute
2009-2025
Australian Research Council
2021-2024
Discovery Centre
2023
Monash Medical Centre
2023
Mayo Clinic
2022
Centro de Investigación Biomédica en Red de Salud Mental
2019
Instituto de Salud Carlos III
2019
Universitat Autònoma de Barcelona
2019
Institute of Research and Innovation Parc Tauli
2019
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although represents approximately 400 pages, material presented is substantially reduced compared information website. It a permanent, citable, point-in-time record that will...
Activation of seven-transmembrane (7TM) receptors by agonists does not always lead to uniform activation all signaling pathways mediated a given receptor. Relative other ligands, many are "biased" toward producing subsets receptor behaviors. A hallmark such "functional selectivity" is cell type dependence; this poses particular problem for the profiling in whole test systems removed from therapeutic one(s). Such response-specific cell-based variability makes it difficult guide medicinal...
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1<i>H</i>-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), 27759 (3-ethyl-5-fluoro-1<i>H</i>-indole-2-carboxylic [2-94-dimethylamino-phenyl)-ethyl]-amide), and 29647 (1-benzyl-pyrrolidin-3-yl)-amide, 2-enedioic salt), at cannabinoid CB<sub>1</sub> receptor. In equilibrium binding assays, compounds significantly increased receptor agonist [<sup>3</sup>H]CP 55,940...
We previously identified the G-protein-coupled receptor Mas, encoded by Mas proto-oncogene, as an endogenous for heptapeptide angiotensin-(1-7); however, is also suggested to be involved in actions of angiotensin II. therefore tested whether this could mediated indirectly through interaction with II type 1 receptor, AT1.In transfected mammalian cells, was not activated II; AT1 receptor-mediated, II-induced production inositol phosphates and mobilization intracellular Ca2+ diminished 50%...