A5021467089- Pregnancy-related medical research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Occupational Health and Performance
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Human Health and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Hypothalamic control of reproductive hormones
- Signaling Pathways in Disease
- Neuroscience of respiration and sleep
- Injury Epidemiology and Prevention
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Sleep and related disorders
Florey Institute of Neuroscience and Mental Health
2016-2025
The University of Melbourne
2016-2025
St Vincents Institute of Medical Research
2023-2024
Monash University
2018
Paracelsus Medical University
2014
University of Bristol
2014
Karolinska Institutet
2014
Mental Health Australia
2014
Neuroscience Institute
2011-2012
The University of Sydney
1986-2008
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands ( www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
The benzomorphan opioid, SKF 10,047, is the prototypical agonist for sigma receptor. In this study, pharmacological and autoradiographic analyses reveal that (+)-[3H]SKF 10,047 labels two sites in brain: a high affinity site resembling receptor second site, labeled with lower by (+)-[3H] similar to phencyclidine (PCP) drug specificity of resembles putative (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine [(+)-[3H]-3-PPP], being potently inhibited (+)-3-PPP, haloperidol (+/-)-pentazocine,...
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which is capable regulating myelination at the individual axon level unclear. Here we demonstrate stimulation somatosensory axons in mouse brain increases proliferation and differentiation oligodendrocyte progenitor cells (OPCs) within underlying white matter. Stimulated display an increased probability being myelinated compared...
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties approximately 1800 drug targets, and about 6000 interactions with 3900 ligands. There an emphasis on selective pharmacology (where available), plus links open access knowledgebase source targets their ligands ( https://www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes almost 500...
3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine (3-PPP) has been proposed as a selective dopamine autoreceptor agonist in the central nervous system. This report describes pharmacology and localization of specific high-affinity binding sites for (+)-[3H]3-PPP brain. The drug specificity is identical to that sigma receptors, which may mediate psychotomimetic effects some opiates. Haloperidol opioid derivatives, pentazocine, cyclazocine, SKF 10,047 are potent inhibitors binding. Stereoselectivity...
Abstract Relaxin is a peptide hormone with known actions associated female reproductive physiology, but it has also been identified in the brain. Only one relaxin gene had characterized rodents until recently when novel human gene, gene‐3 (H3) and its mouse equivalent (M3) were identified. The current study reports identification of rat homologue, (R3) that highly expressed discrete region adult full R3 cDNA was generated using RT‐PCR 3′ 5′ RACE protocols. derived amino acid sequence retains...
Relaxin-3 (RLN3) and its native receptor, relaxin family peptide 3 receptor (RXFP3), constitute a newly identified neuropeptide system enriched in mammalian brain. The distribution of RLN3/RXFP3 networks rat brain recent experimental studies suggest role for this modulation arousal, stress, metabolism, cognition. In order to facilitate exploration the biology complementary murine models, study mapped neuroanatomical mouse Adult, male wildtype RLN3 knock-out (KO)/LacZ knock-in (KI) mice were...
Hippocampal theta rhythm is thought to underlie learning and memory, it well established that “pacemaker” neurons in medial septum (MS) modulate activity. Recent studies the rat demonstrated brainstem-generated occurs through a multisynaptic pathway via nucleus incertus (NI), which primary source of neuropeptide relaxin-3 (RLN3). Therefore, this study examined possible contribution RLN3 MS activity, associated hippocampal activity spatial memory. In anesthetized conscious rats, we identified...
What inhibits the inhibitors? In hippocampus, each memory trace is encoded by a specific subset of pyramidal cells. The other cells must be actively excluded from encoding process inhibition, which done selective dendrite-targeting interneurons. Szőnyi et al. found that γ-aminobutyric acid–releasing (GABAergic) located in small region brain stem called nucleus incertus project to hippocampus. again innervated several regions respond salient stimuli. Its GABAergic preferentially inhibit...
Contextual fear conditioning is a behavioral paradigm used to assess hippocampal-dependent memory in experimental animals. Perception of the context depends on activation distinct population neurons hippocampus and hippocampal-related areas that process discrete aspects perception. In absence any putatively associated cue, becomes salient element may warn an upcoming aversive event; particular conditions, animals generalize this warning new or similar context. study we evaluated effects...
Relaxin-3 is a member of the human relaxin peptide family, gene for which, RLN3, predominantly expressed in brain. Mapping studies rodent indicate highly developed network RLN1, and receptor-expressing cells brain, suggesting that peptides have important functional roles central nervous system. A regioselective disulfide-bond synthesis protocol was used chemical (H3) relaxin-3. The selectively S-protected B chains were combined by stepwise formation each three insulin-like disulfides via...
Abstract Dihydroergotamine (DHE) is the treatment of choice in aborting acute attack migraine. Although its efficacy has been known for 40 years, mechanism action still disputed. Data regarding site dihydroergotamine may provide an insight into and thus identify a locus potentially abnormal pathophysiology By using vitro ex vivo autoradiographic techniques, localization specific binding sites 3 H‐dihydroergotamine cat brain examined. Binding was seen dorsal horn cervical spinal cord,...
The structural determinants of sigma receptor affinity have been evaluated by examining a wide range compounds related to opioids, neuroleptics, and phenylpiperidine dopaminergic structures for at receptor-binding sites labeled with (+)-[3H]3-PPP. Among opioid compounds, requirements differ strikingly from the conventional opiate receptors. Sigma display reverse stereoselectivity classical Multi-ringed opiate-related such as morphine naloxone negligible sites, highest apparent benzomorphans...
Key points The nucleus incertus (NI) is a stress and arousal responsive, hindbrain region involved in ascending control of septohippocampal theta rhythm. NI neurons express high levels the neuropeptide relaxin‐3 corticotrophin‐releasing factor (CRF) receptor‐1 (CRF‐R1). We report first in‐depth characterization neurons, using vivo vitro electrophysiological techniques, which reveal population relaxin‐3‐containing activated by CRF via postsynaptic CRF‐R1 non‐relaxin‐3 neuron inhibited or...