A5073399193- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Regulation of Appetite and Obesity
- Lipid Membrane Structure and Behavior
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Biochemical Analysis and Sensing Techniques
- Radiopharmaceutical Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Adipose Tissue and Metabolism
- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Interference and Gene Delivery
- Biochemical and Structural Characterization
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects and Assays
- Antimicrobial Peptides and Activities
- Molecular Junctions and Nanostructures
- Neurobiology and Insect Physiology Research
- Biotin and Related Studies
- Crystallization and Solubility Studies
- Cell Adhesion Molecules Research
- Boron Compounds in Chemistry
Leipzig University
2016-2025
Institute of Biochemistry
2024
Purdue University West Lafayette
2018-2019
Vanderbilt University Medical Center
2018
Walter de Gruyter (Germany)
2015
Robert Koch Institute
2015
University of Siena
2015
Goethe University Frankfurt
2015
Heinrich Heine University Düsseldorf
2015
University of Pittsburgh
2011
GPR39 is an orphan member of the ghrelin receptor family that recently was suggested to be for obestatin, a peptide derived from precursor. Here, we compare effect obestatin Zn(2+) on signal transduction and study food intake. Although stimulated inositol phosphate turnover, cAMP production, arrestin mobilization, as well response element-dependent serum transcriptional activity in GPR39-expressing cells opposed mock-transfected cells, no reproducible obtained with cells. Moreover, specific...
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties approximately 1800 drug targets, and about 6000 interactions with 3900 ligands. There an emphasis on selective pharmacology (where available), plus links open access knowledgebase source targets their ligands ( https://www.guidetopharmacology.org ), which more detailed views target ligand properties. Although constitutes almost 500...
Abstract Rapid developments in the biotechnology of new proteins, as well advances immunology and development pharmaceuticals based on inhibitors antagonists, have led to immense demands for synthetic peptides. Simultaneous preparation 100–150 completely different peptides, having chain lengths up 20 amino acids can nowadays be achieved using multiple synthesis methods. The yields qualities peptides so obtained are high enough permit reliable vivo vitro screening biological activities....
Abstract Adult dentate neurogenesis is important for certain types of hippocampal‐dependent learning and also appears to be the maintenance normal mood behavioural effects antidepressants. Neuropeptide Y (NPY), a peptide neurotransmitter released by interneurons in gyrus, has on mood, anxiety‐related behaviour memory. We report that adult NPY receptor knock‐out mice have significantly reduced cell proliferation fewer immature doublecortin‐positive neurons gyrus. show neuroproliferative...
The synthesis of more than fifty 36‐residue oligopeptide analogs neuropeptide Y (NPY) and their affinity to human 1 , 2 receptors is described. Each amino acid the natural sequence was replaced by L‐alanine, four alanine residues at position 12, 14, 18 23 were glycine. Additional exchanged closely related ones in order characterize prerequisites for binding. A combination automated single multiple peptide using fluoren‐9‐ylmethoxycarbonyl/ tert ‐butoxy strategy applied. purified peptides...
The neuropeptide Y (NPY) system is a multireceptor/multiligand consisting of four receptors in humans (hY(1), hY(2), hY(4), hY(5)) and three agonists (NPY, PYY, PP) that activate these with different potency. relevance this diseases like obesity or cancer, the role each receptor plays influencing biological processes makes suitable for design subtype selectivity studies. In review we focus on latest findings within NPY system, summarize recent mutagenesis studies, structure activity...
The interactions between glycosaminoglycans (GAGs), important components of the extracellular matrix, and proteins such as growth factors chemokines play critical roles in cellular regulation processes. Therefore, design GAG derivatives for development innovative materials with bio-like properties terms their interaction regulatory is great interest tissue engineering regenerative medicine. Previous work on chemokine interleukin-8 (IL-8) has focused its heparin heparan sulfate, which...
Abstract The melanocortin-4 receptor (MC4R), a hypothalamic master regulator of energy homeostasis and appetite, is class A G-protein-coupled prime target for the pharmacological treatment obesity. Here, we present cryo-electron microscopy structures MC4R–Gs-protein complexes with two drugs recently approved by FDA, peptide agonists NDP-α-MSH setmelanotide, 2.9 Å 2.6 resolution. Together signaling data from structure-derived MC4R mutants, complex reveal agonist-induced origin transmembrane...
In response to three highly conserved neuropeptides, neuropeptide Y (NPY), peptide YY, and pancreatic polypeptide (PP), four G protein-coupled receptors mediate multiple essential physiological processes, such as food intake, vasoconstriction, sedation, memory retention. Here, we report the structures of human Y1, Y2, Y4 in complex with NPY or PP, Gi1 protein. These reveal distinct binding poses upon coupling different receptors, reflecting importance conformational plasticity recognizing...