A5047967960- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- RNA Research and Splicing
- Workplace Health and Well-being
- Nerve injury and regeneration
- Psychological Well-being and Life Satisfaction
- Innovations in Medical Education
- Infant Development and Preterm Care
- Healthcare Decision-Making and Restraints
- Genetic Neurodegenerative Diseases
- MicroRNA in disease regulation
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Nursing Roles and Practices
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- Mental Health and Patient Involvement
- Health Policy Implementation Science
- Clinical Reasoning and Diagnostic Skills
- Pediatric Pain Management Techniques
- Phagocytosis and Immune Regulation
- Global Health Workforce Issues
- Healthcare professionals’ stress and burnout
Monash University
2025
The University of Melbourne
2013-2024
Melbourne Health
2021-2023
Duffy Engineering and Associates (United States)
2022
Harrison Medical Center
2022
Oregon Health & Science University
2019
Center for Neurosciences
2019
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which is capable regulating myelination at the individual axon level unclear. Here we demonstrate stimulation somatosensory axons in mouse brain increases proliferation and differentiation oligodendrocyte progenitor cells (OPCs) within underlying white matter. Stimulated display an increased probability being myelinated compared...
The myelination of axons is a crucial step during vertebrate central nervous system (CNS) development, allowing for rapid and energy efficient saltatory conduction nerve impulses. Accordingly, the differentiation oligodendrocytes, myelinating cells CNS, their expression myelin genes are under tight transcriptional control. We previously identified putative transcription factor, Myelin Regulatory Factor (Myrf), as being vital CNS myelination. Myrf required generation development also its...
Myelin is an essential component of the mammalian nervous system, facilitating rapid conduction electrical impulses by axons, as well providing trophic support to neurons. Within central oligodendrocyte specialized neural cell responsible for producing myelin a process that thought be regulated both activity dependent and independent mechanisms but in incompletely understood ways. We have previously identified protein Gas6, ligand family tyrosine kinase receptors known TAM (Tyro3, Axl,...
Objective We aimed to quantify differences in the brain and spinal cord between Friedreich ataxia controls, stratified by age disease stage, including for first time young children. Methods TRACK‐FA is largest prospective, longitudinal, multi‐modal neuroimaging study date. assessed individuals with 5 42 years, at 7 sites across 4 continents. The 17 imaging primary outcome measures (POMs) were selected from metrics that showed a significant longitudinal change previous small‐scale studies....
Abstract Aim To evaluate a community‐based psychological health and well‐being programme for nurses midwives. Design Mixed methods evaluation. Methods Four studies were included: observational descriptive study (cross‐sectional survey) of the health, experiences previous participants (Study 1); exploratory prospective cohort (longitudinal who engaged in from 2020 to 2023 2); qualitative (interviews) perceptions midwives have with as or clinicians 3); stakeholders 4). Surveys included...
Background: Evidence for analgesic effects of parent-led pain management strategies during painful procedures in newborn infants exists; however, such are inconsistently used practice. A publicly available parent-targeted video demonstrates breastfeeding, skin-to-skin care, and sucrose procedures. Australian parents' use knowledge this these was unknown. Purpose: To determine strategies, perceived acceptability usefulness the video. Methods: cross-sectional, online, anonymous survey with...
Myelination is a highly regulated process in the vertebrate central nervous system (CNS) whereby oligodendrocytes wrap axons with multiple layers of insulating myelin order to allow rapid electrical conduction. Establishing proper pattern neural circuits requires communicative axo-glial interactions, however, molecular interactions that occur between and during developmental myelination maintenance remain be fully elucidated. Our previous work identified G protein-coupled receptor 62...
Oligodendrocyte differentiation and the myelination of axons are crucial steps during vertebrate CNS development, allowing for rapid saltatory conduction action potentials. We previously identified a putative transcription factor, Myelin Regulatory Factor (Myrf, known as MRF GM98), that is vital oligodendrocyte production myelin development. It has been controversial, however, whether Myrf directly regulates transcription, with reports transmembrane domain lack nuclear localization. Here, we...