A5018801509- Ion Channels and Receptors
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Phytochemicals and Antioxidant Activities
- Neurogenesis and neuroplasticity mechanisms
- Herbal Medicine Research Studies
- Circadian rhythm and melatonin
- Acupuncture Treatment Research Studies
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ion Transport and Channel Regulation
- Musculoskeletal pain and rehabilitation
- Healthcare and Venom Research
- Respiratory and Cough-Related Research
- Regulation of Appetite and Obesity
- Nuclear Receptors and Signaling
- Calcium signaling and nucleotide metabolism
- Medicinal plant effects and applications
- Nerve injury and regeneration
- Postharvest Quality and Shelf Life Management
- Cardiac electrophysiology and arrhythmias
- Pain Management and Placebo Effect
The University of Texas Health Science Center at Houston
2016-2025
Southwest Jiaotong University
2025
Brown Foundation
2019-2020
The Ohio State University
2003-2014
The Ohio State University Wexner Medical Center
2012
Tsinghua University
2011
Ministry of Education
2006
Capital Medical University
1998-1999
Peking University
1996
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links open access knowledgebase source and their ligands (www.guidetopharmacology.org), which more detailed views target ligand properties. Although constitutes over 500 pages, material presented substantially reduced compared...
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. provides concise overviews, mostly tabular format, key properties approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There an emphasis on selective pharmacology (where available), plus links open access knowledgebase source targets their ligands (https://www.guidetopharmacology.org/), which more detailed views target ligand properties. Although constitutes almost...
Stem cell-derived motor neurons (MNs) are increasingly utilized for modeling disease in vitro and developing cellular replacement strategies spinal cord injury diseases such as muscular atrophy (SMA) amyotrophic lateral sclerosis (ALS). Human embryonic stem cell (hESC) differentiation into MNs, which involves retinoic acid (RA) activation of the sonic hedgehog (SHH) pathway is inefficient requires up to 60 days develop MNs with electrophysiological properties. This prolonged process has...
Transient receptor potential channels are involved in sensing chemical and physical changes inside outside of cells. TRPV3 is highly expressed skin keratinocytes, where it forms a nonselective cation channel activated by hot temperatures the innocuous noxious range. The has also been implicated flavor sensation oral nasal cavities as well being molecular target some allergens sensitizers. unique that its activity sensitized upon repetitive stimulations. Here we investigated role calcium ions...
Recent studies have found that those who suffer from posttraumatic stress disorder (PTSD) are more likely to experience dementia as they age, most often Alzheimer's disease (AD). These findings suggest the symptoms of PTSD might an exacerbating effect on AD progression. and also share common susceptibility factors such trauma-induced were already succumb with age. Here, we explored these two hypotheses using a mouse model in wild-type animals. We expression human familial mutations amyloid...
Significance Transient Receptor Potential Canonical 4 (TRPC4) forms nonselective cation channels implicated in multiple functions the brain, heart, vasculature, and gastrointestinal tract. However, mechanisms that govern TRPC4 channel activation remain mysterious, severely hampering their functional elucidation under physiological pathological conditions. Uniquely, is activated following ligand stimulation of G protein-coupled receptors function through either q/11 or i/o subgroups proteins....
Abstract Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but rodent models of pain-related OA have concentrated on allodynia rather than pain, and generated non-nociceptive Aβ fibers nociceptors. Little is known about how or nociceptor generated. To define neurophysiological alterations underlying OA, we used isolated dorsal root ganglion neurons that continue generate after removal from animals displaying pain. We subclassify as either spontaneous solely...
Transient receptor potential canonical 3/6/7 (TRPC3/6/7) are highly homologous receptor-operated nonselective cation channels. Despite their physiological significance, very few selective and potent agonists available for functional examination of these Using a cell-based high throughput screening approach, lead compound with the pyrazolopyrimidine skeleton was identified as TRPC6 agonist. Synthetic schemes its analogues were established, structural–activity relationship studies carried out....
Animals must consider competing information before deciding to eat: internal signals indicating the desirability of food and external risk involved in eating within a particular environment. The behaviors driven by former are manifestations hunger, latter, anxiety. connection between pathologic anxiety reduced conditions like typical depression anorexia is well known. Conversely, anti-anxiety drugs such as benzodiazepines increase appetite. Here, we show that GABAergic neurons diagonal band...
Abstract Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding, ageing and obesity; however, the neural basis underlying HFD effects on diurnal remains elusive. Here we show that deletion of BMAL1, a core clock gene, in paraventricular hypothalamic (PVH) neurons reduces rhythmicity metabolism, causes obesity diminishes PVH neuron activation response to fast-refeeding. Animal models mimicking deficiency responsiveness, achieved through clamping activity at...
The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1072]), whose founder member is the Drosophila Trp channel, exists in mammals six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies. subunits contain putative TM domains assemble homo- or hetero-tetramers to form cation selective with diverse modes activation varied permeation properties (reviewed [730]). Established, potential, physiological functions individual members families are...
Abstract Nociceptor cell bodies generate “spontaneous” discharge that can promote ongoing pain in persistent conditions. Little is known about the underlying mechanisms. Recordings from nociceptor (somata) dissociated rodent and human dorsal root ganglia have shown previous vivo associated with low-frequency controlled by irregular depolarizing spontaneous fluctuations of membrane potential (DSFs), likely produced transient inward currents across somal input resistance. Using mouse...
Arthritis leads to bone erosion due an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca 2+ -selective ion channel, Orai1, is critical for maturation. Here, we show small-molecule ELP-004 preferentially inhibits transient receptor potential canonical (TRPC) channels. While minimally affected physiological RANKL-induced maturation in murine marrow– spleen-derived myeloid cells (BMSMCs) human PBMC-derived cells, it potently interfered with...
Background and Purpose Transient receptor potential canonical ( TRPC ) channels play important roles in a broad array of physiological functions are involved various diseases. However, due to lack potent subtype‐specific inhibitors the exact pathophysiological conditions have not been elucidated. Experimental Approach Using fluorescence membrane Ca 2+ assays electrophysiological recordings, we characterized new 2‐aminobenzimidazole‐based small molecule TRPC4 TRPC5 identified from cell‐based...
The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca 2+ ] i ) rise, which are not only important for regulating cell function but their deregulation can also lead to damage. Recent studies have implicated complex roles TRPC in neurodegenerative diseases including ischemic stroke. Brain ischemia reduces oxygen glucose supply neurons, i.e., Oxygen Glucose Deprivation...