Stroke is a leading cause of permanent disability and death. It well accepted that the principal mammalian estrogen (E2), 17-β estradiol, provides robust neuroprotection in variety brain injury models animals both sexes. E2 enhances neurogenesis after stroke subventricular zone; however, it unknown if these cells survive long-term or enhance functional recovery. In this study, we examined stroke-induced male, gonadally intact female, ovariectomized female mice 2 6 weeks stroke. Treatment...

Background: This study analyzed the expression and diagnostic value of hsa_circ_101209 in plasma pregnant women with deep vein thrombosis (DVT).Methods: By circRNA microarray detection GO/KEGG analysis, hsa_circ_14797 targeting miRNA-mRNA network was predicted.Sixty DVT were selected as group, 60 without non-DVT group.hsa_circ_14797 detected, well D-dimer (D-D) concentration P-selectin expression.Target genes that may be regulated by predicted, GO analysis KEGG pathway enrichment...

Background: Stroke outcomes vary with ethnicity, immune response markers like interferon-gamma (IFN-γ) playing a significant role in stroke pathophysiology. IFN-γ, proinflammatory cytokine produced by T cells and natural killer (NK) cells, regulates responses activating macrophages promoting inflammation. Baseline IFN-γ levels healthy African Americans are similar to Whites. Ethnic variations IFN- γ have been noted diseases Rheumatoid arthritis Hepatitis C. Given the worse experienced...

The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca 2+ ] i ) rise, which are not only important for regulating cell function but their deregulation can also lead to damage. Recent studies have implicated complex roles TRPC in neurodegenerative diseases including ischemic stroke. Brain ischemia reduces oxygen glucose supply neurons, i.e., Oxygen Glucose Deprivation...

Abstract Brain microvascular endothelial cells play an essential role in maintaining blood–brain barrier ( BBB ) integrity, and disruption of the aggravates ischemic injury. Ca MKK (α β) is a major kinase activated by elevated intracellular calcium. Previously, we demonstrated that inhibition exacerbated outcomes, conversely, overexpression reduced brain injury after stroke mice. Interestingly, has been shown to activate key protector, sirtuin 1 SIRT 1). We hypothesized protects via...

Long-term disability after stroke is common but the mechanisms of post-stroke recovery remain unclear. Cerebral Ras-related C3 botulinum toxin substrate (Rac) 1 contributes to functional ischemic in mice. As Rac1 plays divergent roles individual cell types central neural system injury, we herein examined specific role neuronal and axonal regeneration. Young male mice were subjected 60-min middle cerebral artery occlusion (MCAO). Inducible deletion by daily intraperitoneal injection tamoxifen...

JOURNAL/nrgr/04.03/01300535-202404000-00033/inline-graphic1/v/2023-09-09T133047Z/r/image-tiff Brain functional impairment after stroke is common; however, the molecular mechanisms of post-stroke recovery remain unclear. It well-recognized that age most important independent predictor poor outcomes as older patients show poorer following stroke. Mounting evidence suggests axonal regeneration and angiogenesis, major forms brain plasticity responsible for recovery, diminished with advanced age....

Neonatal hypoxia–ischemia (HI) is a major cause of death and disability in neonates. HI leads to dramatic rise intracellular calcium levels, which was originally thought be detrimental the brain. However, it has been increasingly recognized that this signaling may also play an important protective role after injury by triggering endogenous neuroprotective pathways. Calcium/calmodulin-dependent protein kinase β (CaMKK β) activated elevated levels calcium. Here we evaluated functional CaMKK...

Purpose: Developmental programming occurs in utero, when epigenetic adaptations Result offspring phenotypes that lead to health consequences persisting throughout life. Programming of cardiac health, due prenatal malnutrition, has been reported rodents but not primate species. Our aim was determine IUGR is associated with impaired function later life a baboon model. Methods: Intrauterine growth restricted (IUGR, mothers were subjected 30% calories reduction) baboons scanned cine MRI...

Respiratory dysfunction is a common complication of stroke, with an incidence over 60%. Despite the high prevalence stroke-induced respiratory dysfunction, how disordered breathing influences recovery and cognitive outcomes after ischemic stroke unknown. We hypothesized that induces chronic instability, apnea in mice, which would contribute to higher mortality greater poststroke deficits.

Introduction: Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid-β (Aβ) in leptomeningeal and cortical vessels. CAA may lead to dementia stroke; however effective options currently are very limited treat or halt progression. EZH2 (enhancer zeste 2 polycomb repressive complex 2) a histone methyltransferase, key regulator inflammation microglia phagocytosis. The present study investigates therapeutic potential an inhibitor (GSK343) mice. Methods: Brain samples were...

Introduction: Respiratory disorders, including sleep apnea, are an independent risk factor for the development of cognitive dysfunction and dementia. Disordered breathing occurs frequently in patients with AD (Alzheimer’s Disease). Disruption brainstem centers, Retro-trapezoid nucleus (RTN), leads to disorders. Our previous work showed that upregulation Transforming Growth Factor Beta Receptor 2 (TGFBR2) signaling RTN respiratory mice. The present study investigated if inhibiting TGFBR2...

<title>Abstract</title> <bold>Introduction: </bold>Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid-beta peptides within cerebral blood vessels, leading to neurovascular complications. Ischemic strokes result from acute disruptions in flow, triggering metabolic disturbances and neurodegeneration. Both conditions often co-occur are associated with respiratory dysfunctions. The retrotrapezoid nucleus (RTN), which crucial for CO₂ sensing breathing...

Neurite plasticity is a critical aspect of functional recovery after stroke. Emerging data suggest that Rac1 plays central role in neurite regeneration the injured brain, specifically by stimulating neuronal intrinsic growth and counteracting inhibitory signaling leads to cone collapse. We assessed hypothesis an important stimulator Transient focal ischemia was induced middle cerebral artery occlusion for 90 minutes 7 8 week old male wild type mice. A specific inhibitor, NSC 23766 (NSC)...

Objective To explore the effect on of combined use Y27632 (ROCK II inhibitor)and TDZD-8(GSK-3β inhibitor)on axonal regeneration dorsal root ganglion (DRG) neurons in neogenetic rats. Methods All thoracolumbar DRGs two Sprague-Dawley (SD)rats(<5 days)were harvested under stereopsis raicrostat,and then DRG were cultured,purified and indentified.Fifteen adult female SD rats randomly divided into three groups,ie,complete paraplegia group(5 rats),sham operation control rats)and normal...