A5018556133- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Dietary Effects on Health
- Neurological disorders and treatments
- Biochemical Analysis and Sensing Techniques
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
Korea National Institute of Health
2022
Korea Disease Control and Prevention Agency
2022
Brown Foundation
2013-2020
Institute of Molecular Medicine
2015
Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other stimulating Our current study mice showed that disruption GABA release from adult GABAergic reduced project extensively to paraventricular hypothalamic nucleus (PVH), and optogenetic stimulation → PVH fibers induced monosynaptic IPSCs neurons, potently increased feeding, which depended on release. In addition,...
Abstract Defective rhythmic metabolism is associated with high-fat high-caloric diet (HFD) feeding, ageing and obesity; however, the neural basis underlying HFD effects on diurnal remains elusive. Here we show that deletion of BMAL1, a core clock gene, in paraventricular hypothalamic (PVH) neurons reduces rhythmicity metabolism, causes obesity diminishes PVH neuron activation response to fast-refeeding. Animal models mimicking deficiency responsiveness, achieved through clamping activity at...