A5061711797- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Insect Resistance and Genetics
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- Force Microscopy Techniques and Applications
- Acute Myocardial Infarction Research
- Ion channel regulation and function
- Protein Structure and Dynamics
- Insect-Plant Interactions and Control
- Insect Pest Control Strategies
- Neural dynamics and brain function
- MicroRNA in disease regulation
- Plant Surface Properties and Treatments
- Pain Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Glaucoma and retinal disorders
- Acute Ischemic Stroke Management
- Medical Imaging and Pathology Studies
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
Foshan Hospital of TCM
2023-2025
Xinqiao Hospital
2025
Universidad Autónoma de Madrid
2025
Shandong University
2022-2024
Second Affiliated Hospital of Zhejiang University
2020-2024
Zhejiang University
2020-2024
Nanjing Agricultural University
2015-2024
Chongqing Cancer Hospital
2022-2024
Chongqing University
2022-2024
Xiamen University
2007-2024
Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions the intact amygdala and prefrontal cortex are required for emotion-based that relies on ability to assess risk, attribute value, identify advantageous strategies. We tested hypothesis pain-related cognitive result from amygdala-driven impairment medial cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo , patch clamp brain slices, various...
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface genetically linked to the risk for Alzheimer’s disease (AD). A proteolytic product, soluble TREM2 (sTREM2), abundant in cerebrospinal fluid and its levels positively correlate with neuronal injury markers. To gain insights into pathological roles of sTREM2, we studied sTREM2 brain 5xFAD mice, model AD, by direct stereotaxic injection recombinant protein or adeno-associated virus (AAV)-mediated...
Marijuana has been used for thousands of years as a treatment medical conditions. However, untoward side effects limit its value. Here, we show that synaptic and cognitive impairments following repeated exposure to Δ9-tetrahydrocannabinol (Δ9-THC) are associated with the induction cyclooxygenase-2 (COX-2), an inducible enzyme converts arachidonic acid prostanoids in brain. COX-2 by Δ9-THC is mediated via CB1 receptor-coupled G protein βγ subunits. Pharmacological or genetic inhibition blocks...
The lateral parabrachial nucleus (LPBN) is known to relay noxious information the amygdala for processing affective responses. However, it unclear whether LPBN actively processes neuropathic pain characterized by persistent hyperalgesia with aversive emotional Here we report that pain-like hypersensitivity induced common peroneal nerve (CPN) ligation increases nociceptive stimulation-induced responses in glutamatergic neurons. Optogenetic activation of GABAergic neurons does not affect basal...
The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer bone physiology. However, little known about the role of CNS development function. To address this question, we performed a detailed characterization knockout mice using molecular, anatomical, electrophysiological, behavioral assays. Quantitative PCR that mRNA was expressed (in order decreasing...
Neuronal apoptosis is one of the main pathological processes hypoxic-ischemic brain damage (HIBD) and involved in development encephalopathy (HIE) neonates. Atorvastatin has been found to have neuroprotective effects some nervous system diseases, but its role regulating pathogenesis neonatal HIBD remains elusive. Thus, this study aimed explore related mechanisms atorvastatin on regulation neuronal after newborn rats. The rat model oxygen glucose deprivation (OGD) were established routinely....
Lesions of the lateral hypothalamus (LH) cause hypophagia. However, activation glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other stimulating Our current study mice showed that disruption GABA release from adult GABAergic reduced project extensively to paraventricular hypothalamic nucleus (PVH), and optogenetic stimulation → PVH fibers induced monosynaptic IPSCs neurons, potently increased feeding, which depended on release. In addition,...
Trisomy 21 induces microglial dysregulation in the Alzheimer’s brain through perturbation of ubiquitin-proteasome system.
The honeybee (Apis mellifera) is a well-known eusocial insect. In colonies, thousands of sterile workers, including nurse and forager bees, perform various tasks within or outside the hive, respectively. queen only fertile female responsible for reproduction. workers share similar genomes but occupy different caste statuses. We established single-cell transcriptomic atlases brains from queens worker subcastes identified five major cell groups: Kenyon, optic lobe, olfactory projection, glial,...
Treatment of triple-negative breast cancer (TNBC) has long been a medical challenge because the lack effective therapeutic targets. Targeting lipid, carbohydrate, and nucleotide metabolism pathways recently proven as promising option in view three heterogeneous metabolic-pathway-based TNBC subtypes. Here, we present multimodal anticancer platinum(II) complex, named Pt(II)caffeine, with novel mode action involving simultaneous mitochondrial damage, inhibition metabolic pathways, promotion...
Aging is a systemic process, which risk factor for impaired physiological functions, and finally death. The molecular mechanisms driving aging process the associated cognitive decline are not fully understood. hypothalamus acts as arbiter that orchestrates through neuroinflammatory signaling. Our recent findings revealed Menin plays important roles in neuroinflammation brain development. Here, we found hypothalamic signaling diminished aged mice, correlates with deficits. Restoring...
The arterial baroreceptor is critically involved in the autonomic regulation of homoeostasis. transient receptor potential vanilloid 1 (TRPV1) expressed on both somatic and visceral sensory neurons. Here, we examined TRPV1 innervation baroreceptive pathways its functional significance baroreflex. Resiniferatoxin (RTX), an ultrapotent analog capsaicin, was used to ablate TRPV1-expressing afferent neurons fibers adult rats. Immunofluorescence labeling revealed that immunoreactivity present...
Cognitive flexibility depends on the integrity of prefrontal cortex (PFC). We showed previously that impaired decision making in pain results from amygdala-driven inhibition medial PFC neurons, but underlying mechanisms remain to be determined. Using whole cell patch clamp rat brain slices and a cognitive behavioral task, we tested hypothesis group I metabotropic glutamate receptors (mGluRs) activate feed-forward decrease excitability output function pyramidal cells, thus impairing making....
Abstract Background Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior evidences suggested that anti-inflammatory function SIRT6 after spinal cord and brain injury, it plays crucial role in macrophages polarization adipose tissue skin. However, involved peripheral nerve injury still unknown. Given prominent recovery, we aim to investigate regulation phenotypes shift functions injury. Results...
Objective This Mendelian randomization (MR) study aimed to investigate the causal relationship between osteoarthritis (OA) and cardiovascular disease (CVD). Methods From a genome-wide association of European ancestry, we selected single nucleotide polymorphisms for two types OA, knee (KOA) hip (HOA), as instrumental variables. We evaluated three CVD: coronary heart (CHD), failure (HF), stroke. used traditional inverse variance weighting (IVW) method other methods estimate causality....