A5100625473- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Vestibular and auditory disorders
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Ear Surgery and Otitis Media
- Voice and Speech Disorders
- Meningioma and schwannoma management
- Digital Marketing and Social Media
- Olfactory and Sensory Function Studies
- Oral and Maxillofacial Pathology
- Cerebral Venous Sinus Thrombosis
- Head and Neck Anomalies
- Mycobacterium research and diagnosis
- Neonatal and fetal brain pathology
- CAR-T cell therapy research
- Adrenal and Paraganglionic Tumors
- Opinion Dynamics and Social Influence
- Complex Network Analysis Techniques
- Immunotherapy and Immune Responses
- Pituitary Gland Disorders and Treatments
- Immune Cell Function and Interaction
West China Hospital of Sichuan University
2013-2025
Sichuan University
2015-2024
West China Second University Hospital of Sichuan University
2022
Chuzhou University
2015-2020
University of Leicester
2013-2020
West China Medical Center of Sichuan University
2001-2019
Union Hospital
2017
Huazhong University of Science and Technology
2017
Shanghai Children's Medical Center
2017
Shanghai Jiao Tong University
2017
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by both a chronic inflammation and tissue remodelling; as indicated extracellular matrix protein deposition, basement membrane thickening, goblet cell hyperplasia subepithelial edema, reduced vessels glands. Although remodelling generally considered to be consequence of persistent inflammation, the chronological order relationship between in polyp development still not clear. The aim our study was therefore investigate...
Neuronal apoptosis is one of the main pathological processes hypoxic-ischemic brain damage (HIBD) and involved in development encephalopathy (HIE) neonates. Atorvastatin has been found to have neuroprotective effects some nervous system diseases, but its role regulating pathogenesis neonatal HIBD remains elusive. Thus, this study aimed explore related mechanisms atorvastatin on regulation neuronal after newborn rats. The rat model oxygen glucose deprivation (OGD) were established routinely....
Background Little is known regarding the role of microbiome paranasal sinuses and its contribution to sinus mucosal health disease. Consequently, we examined chronic rhinosinusitis patients with polyps (CRSwNP) a control population provide new insights into microbiota associated pathogenesis CRSwNP. Methods Fifty‐nine CRSwNP 27 controls were enrolled in study. The bacterial communities middle meatus detected using 16S ribosomal RNA (rRNA)‒targeted Illumina MiSeq sequencing after microbial...
Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that prevalence CRS was about 8 % China. Here, we aim to investigate occupational and environmental risk factors associated with CRS.Data were collected from seven Chinese cities: Urumqi, Changchun, Beijing, Wuhan, Chengdu, Huaian Guangzhou. diagnosed according European Position Paper on Rhinosinusitis Nasal Polyps (EP(3)OS) document....
Mast cells (MCs) are involved in type 2 inflammation chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)-33 stimulation. MiR-221 is reported to be an important regulator of MCs, and miR-221-3p can expressed CRSwNP. However, the role CRSwNP unclear. Ethmoid tissues from control subjects (n = 12) patients 40) were collected. The expression cytokines was detected by real-time quantitative polymerase chain reaction (qPCR). activation P65 ERK determined western...
Background Although oxidative stress is involved in the pathophysiological process of chronic rhinosinusitis with nasal polyps (CRSwNP), specific underlying mechanism still unclear. Whether antioxidant therapy can treat CRSwNP needs further investigation. Methods Immunohistochemistry, immunofluorescence, western blotting and quantitative polymerase chain reaction (qPCR) analyses were performed to detect distribution expression oxidants antioxidants polyp tissues. qPCR revealed correlations...
Background CRSwNP is an inflammatory disease but the mechanism not yet fully understood. MiR-21, a member of miRNAs, has been reported to play roles in mediating inflammation. However, expression miR-21 and its role patients with remain elusive. Methods Turbinates from control subjects, uncinate processes CRSsNP, polyp tissues CRSwNP, nasal epithelial cells brushed mucosa were collected. The cytokines detected by qPCR. localization was ISH, target identified bioinformation analysis, qPCR,...
Bifidobacterium breve (B. breve) may have a beneficial effect on allergic rhinitis (AR). The aim of the present study was to investigate whether microbial induction regulatory T cells (Tregs) and adjustment Th1 Th2 responses by B. are associated with protection against inflammation, identify dose‑response association in murine AR model. Ovalbumin (OVA)‑sensitized BALB/c mice were orally treated different doses [1010, 109, 107 105 colony forming units (CFU)]. Following nasal challenge OVA,...
Abstract To understand the inflammatory microenvironment and microbiome factors for prognosis of chronic rhinosinusitis with polyps (CRSwNP), we explored difference in characteristics nasal sinuses cytokines between recurrent non-recurrent groups. We collected secretions polyp tissue from 77 CRSwNP patients. Then, extracted microbial DNA cotton swabs, performed high-throughput sequencing based on 16S rRNA to detect bacterial community composition, analyzed such as IL-5, IL-8, IL-17a, IL-17e,...
Abstract Inflammatory reaction plays a key role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE) neonates. Microglia are resident innate immune cells central nervous system and profoundly involved neuroinflammation. Studies have revealed that atorvastatin exerts neuroprotective effect by regulating neuroinflammation adult animal models brain stroke traumatic injury, but its regarding damage to developing remains unclear. This study aimed clarify mechanism on regulation microglia...
Asthma is one of the most common chronic diseases and associated with significant morbidity mortality. However, few data on occupational environmental risk factors asthma are available, particularly in Asian adults. Based a national cross-sectional survey, we assessed prevalence Chinese adults.A total 9974 participants aged 15 years over seven cities were selected using stratified four-stage random sampling. All interviewed face-to-face their homes standardized self-administered...