A5101434199- Cancer-related molecular mechanisms research
- interferon and immune responses
- Epigenetics and DNA Methylation
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Genomics and Chromatin Dynamics
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Reproductive tract infections research
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- COVID-19 and healthcare impacts
- Ovarian cancer diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Estrogen and related hormone effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Wnt/β-catenin signaling in development and cancer
- Lipid Membrane Structure and Behavior
Soochow University
2010-2024
Second Affiliated Hospital of Soochow University
2012-2024
Wuhan University
2020-2024
Renmin Hospital of Wuhan University
2020-2024
Pfizer (United States)
2023
University of Alabama at Birmingham
2023
Affiliated Hospital of Guizhou Medical University
2021-2022
Guiyang Medical University
2021-2022
Shengli Oilfield Central Hospital
2021
Shanxi Medical University
2019-2021
An outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan, Hubei, China. People all ages are susceptible to infection. No information on severe pediatric patients with COVID-19 has been reported. We aimed describe the clinical features COVID-19.We included eight or critically ill who were treated at Intensive Care Unit (ICU), Wuhan Children's Hospital from January 24 February 24. collected including demographic data, symptoms, imaging laboratory...
The objectives of this study were to assess the time course enlargement and gene expression a collateral vessel that enlarges following occlusion femoral artery relate these responses increases in collateral-dependent blood flow calf muscles vivo. We employed exercise training stimulate development. Rats trained or kept sedentary for various times up 25 days postbilateral (n=approximately 9/time point). Collateral muscles, determined with microspheres, increased modestly over first few...
DNA methyltransferases (DNMTs), including DNMT1, 3a, and 3b, play an important role in the progression of many malignant tumors. However, it remains unclear whether expression DNMTs is associated with development breast cancer. This study aimed to explore clinical significance DNMT proteins sporadic We investigated 3b 256 cancer 36 fibroadenoma, using immunohistochemistry. The DNMT1 3a was significantly higher than fibroadenoma. In cancer, correlated lymph node metastasis (P = 0.020), DNMT3a...
Abstract Emerging studies have shown that the aberrant expression and function of long non-coding RNAs (lncRNAs) are involved in carcinogenesis development various cancers. The noncoding RNA JPX (lncRNA JPX) on X chromosome is an activator X-inactive-specific transcript (XIST) a molecular switch for X-chromosome inactivation. However, exact mechanism by which acts non-small-cell lung cancer (NSCLC) not well studied. Here, through integrating clinical data series functional experiments, we...
Previous studies have revealed the association of multidrug resistance with histone deacetylases inhibitors treatment in cancer cells. But little data were available for correlation and drug-resistant-related proteins breast tissue. This study aimed to exploring expression clinicopathological features, proteins, prognosis therapeutic responses patients.We performed immunohistochemistry HDAC1 HDAC2 226 34 fibroadenoma patients, protein, P-glycoprotein, lung protein cancer.In cancer, was...
We previously reported that prior training improves collateral blood flow (BF) to the calf muscles after acute-onset occlusion of femoral artery (Yang HT et al. Am J Physiol Heart Circ 279: H1890–H1897, 2000). The purpose this study was test hypothesis increased release nitric oxide (NO) by NO synthase (likely endothelial NOS) contributes BF trained rats acute occlusion. Adult male Sprague-Dawley (∼325 g) were limited cage activity and sedentary (SED; n = 28) or exercise (TR; 30) for 6 wk...
Cushing's disease is primarily caused by pituitary adrenocorticotropin‑secreting adenoma. However, its pathogenesis has remained obscure. In the present study, whole transcriptome analysis was performed RNA sequencing (RNA‑Seq) and expression of secreted frizzled‑related protein 2 (SFRP2) decreased in corticotroph tumors compared with normal glands. Furthermore, RNA‑Seq results were validated SFRP2 tumor tissues analyzed comparing another cohort 23 patients 3 human samples using reverse...
Previous studies have indicated that microRNA (miR)-210-3p is upregulated in NSCLC, however, the specific mechanism underlying role of miR-210-3p NSCLC pathogenesis requires further investigation. The aim present study was to explore roles and associated mechanisms. A total 30 tissues paired adjacent normal were collected for study. Reverse transcription-quantitative polymerase chain reaction performed compare expression cancerous tissues. Additionally, different lines human lung epithelial...
Breast cancer is a complex disease; the molecular mechanisms involved in sporadic breast carcinogenesis remain to be elucidated. The present study aimed explore deficiency of susceptibility gene 1 (BRCA1), including protein loss expression, promoter hypermethylation and copy deletion, its correlationship with other tumor markers expression (TP53, MYC, etc.), clinical significance cancer. BRCA1 was negative 226 374 (60.4 %) cases this study. Cases for were more often pathological...
This study was designed to explore the protective effect of D4F, an apolipoprotein A-I mimetic peptide, on nuclear factor-κB (NF-κB)-dependent Fas/Fas ligand (FasL) pathway-mediated apoptosis in macrophages induced by oxidized low-density lipoprotein (ox-LDL). Our results showed that ox-LDL apoptosis, NF-κB P65 translocation and upregulation Fas/FasL pathway-related proteins, including Fas, FasL, Fas-associated death domain proteins (FADD), caspase-8 caspase-3 RAW264.7 macrophages, whereas...
BACKGROUND Current clinical tools have limited accuracy in differentiating patients with localized prostate cancer who are at risk of recurrence from indolent disease. We aimed to identify a gene expression signature that jointly variables could improve upon the prediction after RP for stage T2 PCa. METHODS The study population includes consented underwent radical retropubic prostatectomy (RP) and bilateral pelvic lymph node dissection University Southern California PSA‐era (1988–2008). used...
Abstracts Background Cancer patients are considered to be highly susceptible viral infections, however, the comprehensive features of COVID-19 in these remained largely unknown. The present study aimed assess clinical characteristics and outcomes a large cohort cancer patients. Design, Setting, Participants Data consecutive admitted 33 designated hospitals for Hubei province, China from December 17, 2019 March 18, 2020 were retrospectively collected. follow-up cutoff date was April 02, 2020....
Abstract Background Triple-negative breast cancer (TNBC) is the most lethal subtype of (BC). The circRNA-miRNA‒mRNA axis a promising biomarker for early diagnosis and prognosis BC. However, critical circRNA mediators involved in TNBC progression underlying regulatory mechanism remain largely unclear. Methods In this study, we carried out microarray analysis 6 patients performed gene ontology (GO) analysis. Kyoto Encyclopedia Genes Genomes (KEGG) was used to characterize important circRNAs...
The aim of the present study was to investigate effectiveness laparoscopic gallbladder‑preserving surgery (L‑GPS) for cholelithiasis and feasibility value totally GPS (TL‑GPS). A total 517 patients underwent L‑GPS, including 365 cases laparoscopy‑assisted (LA‑GPS), 143 TL‑GPS (preservation rate, 98.3%) nine conversions cholecystectomy. surgeries were all performed by one medical team mean operating time 72 min. All macroscopic calculi removed through endoscopy. number observed in between...