A5101991794- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Esophageal and GI Pathology
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Global Cancer Incidence and Screening
- COVID-19 and healthcare impacts
- Renal Transplantation Outcomes and Treatments
- Breast Cancer Treatment Studies
- Cancer survivorship and care
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Economic and Financial Impacts of Cancer
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Wnt/β-catenin signaling in development and cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Treatment and Pharmacology
- Connective tissue disorders research
- Cholinesterase and Neurodegenerative Diseases
- Cancer Diagnosis and Treatment
Tianjin Academy of Agricultural Sciences
2025
Mianyang Central Hospital
2013-2024
University of Electronic Science and Technology of China
2021-2024
Sichuan Mianyang 404 Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
North Sichuan Medical University
2015-2022
Nanchong Central Hospital
2016-2022
China Three Gorges University
2021
Yichang Central People's Hospital
2021
Huazhong University of Science and Technology
2020
Significance Serum microRNAs (miRNAs) have emerged as potential noninvasive biomarkers to diagnose prostate cancer (PCa), the most common noncutaneous malignancy among Western men. However, intermediate grades of PCa cannot be distinguished from aggressive forms using current miRNA signatures due heterogeneity PCas. Recently, a high-throughput, spherical nucleic acid-based expression profiling platform, called Scano-miR bioassay, was developed measure levels miRNAs with both high sensitivity...
The treatment of non-small cell lung cancer (NSCLC) with immune checkpoint inhibitors (ICIs) has been proven to induce lasting tumor remission. Screening suitable populations for immunotherapy through predictive markers is an important approach improving the clinical benefits patients. Evidence shown that there may be a close connection between NOTCH signaling and microenvironment (TME). Hence, we explored impact mutation status on prognosis NSCLC patients treated aim apply greatest extent...
Purpose Given the unique features of liver, it is necessary to combine immunotherapy with other therapies improve its efficacy in patients advanced cancer liver metastases (LM). High-intensity focused ultrasound (HIFU) ablation now widely used clinical practice and can enhanced immune benefits. The study intended prospectively evaluate safety feasibility HIFU combination systemic for metastases. Methods enrolled 14 LM who received ultrasound-guided combined checkpoint inhibitors (ICIs) such...
Ethylene response factors (ERFs) are transcription that essential in modulating drought stress responses plants such as Arabidopsis and rice. However, the functional role of ERF wheat remains unclear. We identified 33 genes under using transcriptomic analysis categorized them into eight subfamilies (I–VIII). Among them, 12 drought-responsive candidate were upregulated, TaERF13-2B was selected for further analysis. overexpression resulted significantly reduced survival rates conditions with...
There is a need for new therapies in Parkinson's disease that may help to address known limitations of current options. PF-06649751 novel, highly selective dopamine D1/D5 agonist targeted treatment.The safety, pharmacokinetics, and pharmacodynamics were assessed single ascending dose multiple clinical trials patients with disease. The study (N = 18) was double-blind, placebo-controlled three-way crossover design consisting three treatment periods separated by 7-day drug washout periods....
Background and purposeThis study aimed to evaluate the efficacy of radical radiotherapy assess prognostic factors in metachronous oligometastatic esophageal cancer (MOEC) patients after initial treatment with curative-intent surgery and/or chemoradiotherapy.Materials methodsMOEC Patients during 2009–2018 Mianyang Central Hospital were retrospectively analyzed. Each patient had ≤5 lesions, primary lesions controlled this study. devided into (RT) non-radiotherapy (NRT) groups. The endpoints...
Abstract The effect of PF-06372865, a subtype-selective positive allosteric modulator the γ-aminobutyric acid type A (GABA ) receptor, on chronic low back pain was investigated in randomised, placebo- and active-controlled phase 2 clinical trial. parallel treatment group trial consisted 1-week single-blind placebo run phase, followed by 4-week double-blind treatment. Patients were randomised to receive either naproxen, or twice day for 4 weeks. primary end point numerical rating score...
Abstract Background: Acute radiation dermatitis (ARD) is a common adverse effect in patients undergoing radiotherapy. Mometasone furoate cream (MMF) was reported to significantly reduce ARD, especially breast cancer. Clinically, ARD more critical and difficult prevent with head neck squamous cell carcinoma (HNSCC) than those cancer, because higher dose of radiotherapy required HNSCC cases. The aim this study evaluate the MMF local application on HNSCC. Methods: scheduled for bilateral...
Lung cancer is the most common malignancy worldwide. With continuous spread of coronavirus disease 2019 (COVID-19) globally, it great significance to explore impact this on clinical characteristics lung cancer. Thus, we aimed investigate whether COVID-19 pandemic had any influence and diagnosis patients with We collected demographic data who were newly diagnosed at our hospital between February July 2020. Overall, 387 divided into two groups for analysis: epidemic group (from 2020)...
Abstracts Background Cancer patients are considered to be highly susceptible viral infections, however, the comprehensive features of COVID-19 in these remained largely unknown. The present study aimed assess clinical characteristics and outcomes a large cohort cancer patients. Design, Setting, Participants Data consecutive admitted 33 designated hospitals for Hubei province, China from December 17, 2019 March 18, 2020 were retrospectively collected. follow-up cutoff date was April 02, 2020....
Background Multidisciplinary team (MDT) meetings are the gold standard of cancer treatment. However, limited participation multiple medical experts and low frequency MDT reduce efficiency coverage rate MDTs. Herein, we retrospectively report results an asynchronous based on a cloud platform (cMDT) to improve for digestive tract cancer. Methods The participants cMDT processes associated with were discussed using platform. Software programming test runs subsequently conducted further software...
Cervical cancer is known to impair women's sexual function. This study aimed at investigating the attitudes and behavior of radiation oncologists regarding functioning female cervical patients who receive therapy.A total 186 were included. A self-reported questionnaire was used investigate oncologists. The queried on their history consultation issues, attitudes, toward issues considerations life for radiotherapy.Among 120 completed questionnaires, 101 (84.2%) had been consulted whom only 29...
Abstract Till now, no appropriate biomarkers for high‐risk population screening and prognosis prediction have been identified patients with oesophageal squamous cell carcinoma (ESCC). In this study, by the combined use of data from Gene Expression Omnibus (GEO) datasets The Cancer Genome Atlas (TCGA)‐oesophageal (ESCA), we aimed to screen dysregulated genes prognostic value in ESCC genetic epigenetic alterations underlying dysregulation. About 222 that had at least fourfold change compared...
The efficacy of single-agent chemotherapy was not significantly different from that double-agent in concurrent chemoradiotherapy for inoperable esophageal squamous cell carcinoma. Single-agent had lower gastrointestinal and hematologic toxicity. Overall survival progression-free were between single- chemoradiotherapy.This multicenter, randomized, phase II trial aimed to compare the safety using oral fluoropyrimidine S-1 with those cisplatin patients carcinoma.Patients carcinoma (clinical...
Background: This study aimed to investigate the specificity and sensitivity of oral meglumine diatrizoate esophagogram in screening for esophageal fistula during radiotherapy or chemoradiotherapy cancer determine if early detection intervention could improve prognosis fistulas. Methods: Esophageal patients undergoing were included. Weekly esophagograms performed screen fistulas radiotherapy. When an was detected, fibro-esophagoscopy computed tomography (CT) used confirmation; once confirmed,...
Abstract Lessons Learned Background This study aimed to evaluate the efficacy and safety of anlotinib combined with S-1 as a third- or later-line treatment for patients stage IV non-small cell lung cancer (NSCLC). Anlotinib was approved in 2018 by Chinese Food Drug Administration (FDA) third-line refractory advanced NSCLC is under U.S. Europe. Methods Simon's phase II clinical trial design an α error 5% power β 80% used, anticipating 10% objective response rate (ORR) 30% ORR S-1; required...
Abstract Context The impact of parental overweight/obese on cumulative live birth rate in vitro fertilization/intracytoplasmic sperm injection using a freeze-all strategy is still unknown. Objective To explore the effect body mass index (BMI) (CLBR) over 1.5 years. Methods This was retrospective study tertiary care academic medical center; 23 482 patients (35 289 frozen–thawed embryo transfer cycles) were divided into 4 groups according to Asian BMI classification. main outcome measure CLBR....
Abstract Introduction: Re-irradiation after radiotherapy is a common treatment for locally recurrent esophageal cancer. However, the side effects of re-irradiation are serious. The most serious adverse reactions include perforation and hemorrhage caused by perforation. Studies have shown that pulsed low-dose rate (PLDR) induces hypersensitivity effect on tumor tissue hyper-repair normal tissue, which can simultaneously reduce damage increase therapeutic tumor. objective this study to explore...
Introduction: This study aimed to compare the efficacy and safety of docetaxel + trastuzumab pertuzumab carboplatin for treating HER2-positive breast cancer. Method: cancer from patients diagnosed between January 2020 September 2022 were included in this retrospective study. Docetaxel or was selected as neoadjuvant regimen. The primary endpoint a complete pathological remission rate. Secondary endpoints toxicity during treatment, adjustment therapy scheme, adjuvant medication. Result: A...